Results 41 to 50 of about 50,133 (121)

Progress in research on mitophagy and pulmonary diseases [PDF]

Jichu yixue yu linchuang, 2020
Mitophagy is one of the important forms of selective autophagy, which affects the occurrence and development of lung diseases by regulating the quality of mitochondria in vivo. Mitophagy has different functions in different lung diseases.
TAN Shi-Yi, CHEN Shi
doaj  

Synthetic Quantitative Array Technology Identifies the Ubp3-Bre5 Deubiquitinase Complex as a Negative Regulator of Mitophagy

Cell Reports, 2015
Mitophagy is crucial to ensuring mitochondrial quality control. However, the molecular mechanism and regulation of mitophagy are still not fully understood.
Matthias Müller, Peter Kötter, Christina Behrendt, Elena Walter, Christian Q. Scheckhuber, Karl-Dieter Entian, Andreas S. Reichert   +6 more
doaj   +1 more source

Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila

eLife, 2018
Mutations in the genes for PINK1 and parkin cause Parkinson’s disease. PINK1 and parkin cooperate in the selective autophagic degradation of damaged mitochondria (mitophagy) in cultured cells.
Tom Cornelissen, Sven Vilain, Katlijn Vints, Natalia Gounko, Patrik Verstreken, Wim Vandenberghe   +5 more
doaj   +1 more source

Mitophagy in breast cancer: Regulatory mechanisms and therapeutic potential

Chinese Medical Journal
. Breast cancer (BC) is the most prevalent malignancy among women and presents significant challenges, such as drug resistance and relapse, particularly triple-negative breast cancer (TNBC).
Yujing Chang, Yongjie Zhou, Libo Yang, Leyi Gao, Yu Zhang, Mengna Feng, Mengjia Shen, Bing Wei, Hong Bu, Zhang Zhang, Jing Ni   +10 more
doaj   +1 more source

Acylglycerol Kinase Inhibition Restores Mitophagy and Alleviates Alzheimer's Disease Pathology

MedComm
Mitophagy is a conserved cellular process that removes dysfunctional or excess mitochondria. Increasing evidence suggests that impaired mitophagy plays a crucial role in AD development. Promoting mitophagy has been shown to be protective in models of AD,
Wensheng Li, Xuan Yu, Cuiping Guo, Yuting Huang, Zhen Wei, Yi Liu, Jian‐Zhi Wang, Rong Liu, Weike Ji, Qiuhong Duan, Jing Wang, Guihua Wang, Xiaochuan Wang   +12 more
doaj   +1 more source

Mitochondrial autophagy in neural function, neurodegenerative disease, neuron cell death, and aging

Neurobiology of Disease, 2011
Macroautophagy is a cellular process by which cytosolic components and organelles are degraded in double-membrane bound structures upon fusion with lysosomes.
Yakup Batlevi, Albert R. La Spada
doaj   +1 more source

Role of mitophagy in breast cancer: mitophagy-apoptosis balance and reactive oxygen species play determining role

Frontiers in Physiology
This review aims to present a current overview of the role of mitophagy in breast cancer progression, especially from the point of view of when the cancer is in the untreated state or under chemotherapeutic treatment.
Lung Yiu, Yan Wah Chong, Shuyi Yan, Suk Ying Tsang, Suk Ying Tsang, Suk Ying Tsang, Suk Ying Tsang   +6 more
doaj   +1 more source

Mitophagy: insights into its signaling molecules, biological functions, and therapeutic potential in breast cancer

Cell Death Discovery
Mitophagy, a form of selective autophagy that removes damaged or dysfunctional mitochondria, plays a crucial role in maintaining mitochondrial and cellular homeostasis.
Cong Chen, Aizhai Xiang, Xia Lin, Jufeng Guo, Jian Liu, Shufang Hu, Tao Rui, Qianwei Ye   +7 more
doaj   +1 more source

Hepatitis C Virus NS5A Activates Mitophagy Through Cargo Receptor and Phagophore Formation

Pathogens
Chronic HCV infection is a risk factor for end-stage liver disease, leading to a major burden on public health. Mitophagy is a specific form of selective autophagy that eliminates mitochondria to maintain mitochondrial integrity.
Yuan-Chao Hsiao, Chih-Wei Chang, Chau-Ting Yeh, Po-Yuan Ke   +3 more
doaj   +1 more source

SIRT1/PGC-1α-mediated mitophagy participates the improvement roles of BMAL1 in podocytes injury in diabetic nephropathy: evidences from in vitro experiments

European Journal of Medical Research
Background Dysfunction in podocyte mitophagy has been identified as a contributing factor to the onset and progression of diabetic nephropathy (DN), and BMAL1 plays an important role in the regulation of mitophagy.
Yanxia Rui, Yinfeng Guo, Linying He, Min-er Wang, Henglan Wu   +4 more
doaj   +1 more source