Results 61 to 70 of about 3,826 (176)

From Covalent Traps to Fluorescent Beacons: The Expanding Arsenal of Chemical Probes for Studying Ubiquitin and Ubiquitin‐Like Proteins

Angewandte Chemie, Volume 138, Issue 13, 23 March 2026.
A large variety of chemistry‐based ubiquitin probes have been developed. ABSTRACT Ubiquitin (Ub) and ubiquitin‐like proteins (Ubls) orchestrate diverse cellular processes through reversible post‐translational modification of target proteins. Their conjugation is governed by a cascade of E1 activating, E2 conjugating, and E3 ligating enzymes, while ...
Saibal Chanda, Wenshe Ray Liu
wiley   +2 more sources

Ubiquitin-Specific Protease 14 Negatively Regulates Toll-Like Receptor 4-Mediated Signaling and Autophagy Induction by Inhibiting Ubiquitination of TAK1-Binding Protein 2 and Beclin 1

Frontiers in Immunology, 2017
Ubiquitin-specific protease 14 (USP14), one of three proteasome-associated deubiquitinating enzymes, has multifunctional roles in cellular context. Here, we report a novel molecular mechanism and function of USP14 in regulating autophagy induction and ...
Yoon Min, Sena Lee, Mi-Jeong Kim, Eunyoung Chun, Eunyoung Chun, Ki-Young Lee, Ki-Young Lee, Ki-Young Lee   +7 more
doaj   +1 more source

USP14 exhibits high expression levels in hepatocellular carcinoma and plays a crucial role in promoting the growth of liver cancer cells through the HK2/AKT/P62 axis

BMC Cancer
Background Hepatocellular carcinoma (HCC) is a common malignant tumor with strong invasiveness and poor prognosis. Previous studies have demonstrated the significant role of USP14 in various solid tumors.
Nannan Zhang, Hui Zhang, Xiaobing Yang, Qiang Xue, Quhui Wang, Renan Chang, Lirong Zhu, Zhong Chen, Xiancheng Liu   +8 more
doaj   +1 more source

Post‐Translational Modifications of Key Proteins in Hematologic Malignancies: Carcinogenic Mechanisms, Biomarker Potential, and New Therapeutic Strategies

iLABMED, EarlyView.
This article reviews the pivotal role of post‐translational modifications of proteins in the development and progression of hematologic malignancies, and explores their clinical translation potential as novel biomarkers and therapeutic targets. ABSTRACT Post‐translational modifications (PTMs) of proteins have emerged as critical regulators in the ...
Yuxuan Han, Chaowei Zhang, Weiyi Yao, Qing Hong, Xinyu Tang, Yanan Zhu, Na Chen   +6 more
wiley   +1 more source

Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling [PDF]

, 2014
Dishevelled (Dvl) is a key regulator of Wnt signaling both in the canonical and non-canonical pathways. Here we report the identification of a regulatory domain of ubiquitination (RDU) in the C-terminus of Dvl.
Jung, H, Lee, J H, Park, W S, Han, W H, Cho, J-Y, Lee, M J, Maurice, M M, Finley, D, Kim, B-G, Han, J-K, Jho, E-h   +10 more
core   +1 more source

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, EarlyView.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

Gastric Cancer: Pathobiology and Therapeutics

MedComm, Volume 7, Issue 6, June 2026.
Gastric cancer is a multistep process driven by the interplay of microbial virulence, host epithelial injury, and evolving molecular reprogramming. Initiation involves pathogen‐induced epigenetic alterations and the early subversion of key oncogenic signaling networks, facilitating the transition from chronic injury to metaplasia and malignant ...
Ruixian Yu, Miao Zhang, Yan Meng, Chunxiao Zhu, Weihong Zhang, Hui Zhang, Zhifa Cao, Meihang Du, Zhangting Zhao, Junping Bai, Yi Han, Yang Tang, Wei Kang, Ka Fai To, Shi Jiao, Liwei An, Zhaocai Zhou   +16 more
wiley   +1 more source

Ubiquitinated Proteins Activate the Proteasomal ATPases by Binding to Usp14 or Uch37 Homologs [PDF]

Journal of Biological Chemistry, 2013
Degradation of ubiquitinated proteins by 26 S proteasomes requires ATP hydrolysis, but it is unclear how the proteasomal ATPases are regulated and how proteolysis, substrate deubiquitination, degradation, and ATP hydrolysis are coordinated. Polyubiquitinated proteins were shown to stimulate ATP hydrolysis by purified proteasomes, but only if the ...
Andreas, Peth, Nikolay, Kukushkin, Marc, Bossé, Alfred L, Goldberg   +3 more
openaire   +2 more sources

Ubiquitin‐Specific Protease 45 Inhibits Lung Adenocarcinoma Ferroptosis by Regulating Ubiquitination and Stability of Glutathione Peroxidase 4

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Lung adenocarcinoma is the most common subtype of lung cancer and the leading cause of cancer‐related mortality worldwide. Ferroptosis, a regulated form of cell death characterized by iron‐dependent lipid peroxidation, has emerged as a promising therapeutic target for lung adenocarcinoma.
Mingxiang Huang, Meilan Fang, Yao Wang, Shanshan Liu, Fengqin Li   +4 more
wiley   +1 more source

Reactivity of USP14 toward ISG15VS is augmented by proteasomal association.

, 2013
USP14 and USP5 were generated by IVT. Their activity toward ISG15VS and UbVME was analyzed in the presence of increasing concentrations of purified human 26S proteasomes.
Daniël Blom (32523), Paul J. Galardy (32524), André Catic (32520), Hidde L. Ploegh (32525), Edda Fiebiger (32521), Gregory A. Korbel (32522)   +5 more
core   +1 more source