Results 31 to 40 of about 3,826 (176)

miR-4782-3p Inhibited Non-Small Cell Lung Cancer growth via USP14

Cellular Physiology and Biochemistry, 2014
Background: Lung cancer is the leading cause of cancer-related mortality worldwide, with near 1.4 million deaths each year. NSCLC accounts for nearly 85% of all case of lung cancer. MiRNAs play important roles in regulation of gene expression at the post-
Ning Wu, Chaoxiong Zhang, Chong Bai, Yi Pang Han, Qiang Li   +4 more
doaj   +2 more sources

Inhibition of USP14 Deubiquitinating Activity as a Potential Therapy for Tumors with p53 Deficiency [PDF]

Molecular Therapy: Oncolytics, 2020
Functional elimination of p53 is a common feature of a large percentage of human malignancies. Here, we report the development of a pharmacological strategy aimed at restoring p53 function and its use for targeted therapy in p53-deficient mice.
Yu-Shui Ma, Xiao-Feng Wang, Yun-Jie Zhang, Pei Luo, Hui-Deng Long, Liu Li, Hui-Qiong Yang, Ru-Ting Xie, Cheng-You Jia, Gai-Xia Lu, Zheng-Yan Chang, Jia-Jia Zhang, Shao-Bo Xue, Zhong-Wei Lv, Fei Yu, Qing Xia, Da Fu   +16 more
doaj   +3 more sources

The Cullin3–Ring E3 ubiquitin ligase complex and USP14 regulate spastin-mediated microtubule severing and promotion of neurite outgrowth [PDF]

Neural Regeneration Research
Post-translational modification of spastin enables precise spatiotemporal control of its microtubule severing activity. However, the detailed mechanism by which spastin turnover is regulated in the context of neurite outgrowth remains unknown.
Zhenbin Cai, Hui Wu, Tao Jiang, Ao Ma, Zhichao Meng, Jiehao Zhu, Hongsheng Lin, Yaozhong Liang, Guowei Zhang, Minghui Tan   +9 more
doaj   +2 more sources

The Deubiquitinating Enzyme USP14 Regulates Leukemic Chemotherapy Drugs-Induced Cell Apoptosis by Suppressing Ubiquitination of Aurora Kinase B

Cellular Physiology and Biochemistry, 2017
Background/Aims: Aurora kinase B is a mitotic checkpoint kinase that plays a pivotal role in mitosis by ensuring correct chromosome segregation and normal progression through mitosis.
Chunge Song, Ruojin Ma, Xiaoyu Yang, Sulei Pang   +3 more
doaj   +2 more sources

Insights into the potential role of BMSCs-exo delivered USP14 on SIRT1 deubiquitination in Staphylococcus aureus-induced model of osteomyelitis [PDF]

Journal of Orthopaedic Surgery and Research
Osteomyelitis resulting from a traumatic fracture is a recurrent and difficult-to-treat bone infection. Ubiquitin-specific protease 14 (USP14), a deubiquitinating enzyme, and Sirtuin-1 (SIRT1), an NAD+-dependent deacetylase, both play critical roles in ...
Jun Yu, Ming Yang, Yun Jin, Kaijie Yang, Haibo Yang   +4 more
doaj   +2 more sources

Distinct effects of ubiquitin overexpression on NMJ structure and motor performance in mice expressing catalytically inactive USP14

Frontiers in Molecular Neuroscience, 2015
Ubiquitin-specific protease 14 (USP14) is a major deubiquitinating enzyme and a key determinant of neuromuscular junction (NMJ) structure and function. We have previously reported dramatic ubiquitin depletion in the nervous systems of the USP14-deficient
Jada H Vaden, Jennifer Ashley Watson, Alan David Howard, Ping-Chung eChen, Julie Ann Wilson, Scott Michael Wilson   +5 more
doaj   +2 more sources

Lovastatin Targets the USP14–Survivin Axis to Suppress Triple-Negative Breast Cancer via Ubiquitin-Mediated Proteasomal Degradation [PDF]

Cells
Triple-negative breast cancer (TNBC), characterized by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor type 2 (HER2) expression, represents a therapeutic challenge due to its aggressive nature
Li Zhou, Chanjuan Zheng, Siyu Ding, Zhiyu Wang, Yiyuan Yang, Yian Wang, Guangchun He, Shujun Fu, Xiyun Deng   +8 more
doaj   +2 more sources

USP14 inhibition by degrasyn induces YAP1 degradation and suppresses the progression of radioresistant esophageal cancer

Neoplasia: An International Journal for Oncology Research
Background: Radiotherapy is a major modality for esophageal cancer (ESCA) treatment, yet radioresistance severely hampers its therapeutic efficacy. Ubiquitin-specific peptidase 14 (USP14) is a novel deubiquitinase and can mediate cancer cells’ response ...
Fang Yuan, Juan Xu, Lingmei Xuan, Chan Deng, Wei Wang, Rong Yang   +5 more
doaj   +2 more sources

Mechanistic insights into dynamic mutual regulation of USP14 and proteasome [PDF]

Nature, 2021
Abstract Proteasomal degradation of ubiquitylated proteins is sophisticatedly regulated at multiple levels 1–3 . A primary regulatory checkpoint is the removal of ubiquitin chains from substrates by the deubiquitylating enzyme USP14 that associates reversibly with the proteasome ...
Shuwen Zhang, Shitao Zou, Deyao Yin, Daniel Finley, Zhaolong Wu, Youdong Mao   +5 more
openaire   +3 more sources

USP14-mediated stabilization of ACTN1 maintains mesenchymal characteristics in glioblastoma. [PDF]

Commun Biol
Glioblastoma (GBM) is a highly aggressive primary brain tumor with a dismal prognosis, particularly in its mesenchymal (MES) subtype, which correlates strongly with poor survival. Despite this, the mechanisms preserving MES identity remain poorly understood.
Qiu W, Shi X, Wei R, Song J, Ling Y, Hu Y, Song S, Chen Y, Yang H, Luo P, Chu L.   +10 more
europepmc   +3 more sources