Results 31 to 40 of about 4,153 (179)
BIFUNCTIONAL MOLECULES FOR TARGETING USP14
, 2019 The invention provides for bifunctional molecules comprising an Usp14 binding partner and a target protein binding partner. A bifunctional molecule according to the invention binds to Usp14 and to the target protein, thereby facilitating degradation of ...
Testa, Andrea +3 more
core +2 more sources
Inhibition of USP14 Deubiquitinating Activity as a Potential Therapy for Tumors with p53 Deficiency [PDF]
Molecular Therapy: Oncolytics, 2020 Functional elimination of p53 is a common feature of a large percentage of human malignancies. Here, we report the development of a pharmacological strategy aimed at restoring p53 function and its use for targeted therapy in p53-deficient mice.
Yu-Shui Ma +16 more
doaj +3 more sources
Distinct effects of ubiquitin overexpression on NMJ structure and motor performance in mice expressing catalytically inactive USP14 [PDF]
Frontiers in Molecular Neuroscience, 2015 Ubiquitin-specific protease 14 (USP14) is a major deubiquitinating enzyme and a key determinant of neuromuscular junction (NMJ) structure and function. We have previously reported dramatic ubiquitin depletion in the nervous systems of the USP14-deficient
Jada H Vaden +5 more
doaj +2 more sources
Artificial Cells, Nanomedicine, and Biotechnology, 2019 Matrine derivative MASM (M19) is a quinolizine alkaloid with diverse pharmacological effects including preventing postmenopausal osteoporosis. In the current study, we observed that pretreatment with M19 inhibited cell apoptosis of murine osteoblastic ...
Panyu Zhou +7 more
doaj +2 more sources
Mechanistic insights into dynamic mutual regulation of USP14 and proteasome [PDF]
Nature, 2021 Abstract Proteasomal degradation of ubiquitylated proteins is sophisticatedly regulated at multiple levels 1–3 . A primary regulatory checkpoint is the removal of ubiquitin chains from substrates by the deubiquitylating enzyme USP14 that associates reversibly with the proteasome ...
Shuwen Zhang +5 more
openaire +3 more sources
Deubiquitinase USP5 suppresses ferroptosis in lung adenocarcinoma by deubiquitinating and stabilizing GPX3. [PDF]
J Cell Commun Signal1. USP5 overexpression in LUAD predicts poor prognosis, linking to tumor progression and therapy resistance. 2. USP5 deubiquitinates/stabilizes GPX3, maintaining antioxidant defense against ferroptosis. 3. Targeting inhibition of USP5 enhances LUAD ferroptosis sensitivity, offering therapeutic potential. Abstract Ferroptosis is a regulated form of cell
Fan X +8 more
europepmc +2 more sources
The deubiquitinating enzyme Usp14 controls ciliogenesis and Hedgehog signaling [PDF]
Human Molecular Genetics, 2018 Primary cilia are hair-like organelles that play crucial roles in vertebrate development, organogenesis and when dysfunctional result in pleiotropic human genetic disorders called ciliopathies, characterized by overlapping phenotypes, such as renal and hepatic cysts, skeletal defects, retinal degeneration and central nervous system malformations ...
MASSA, FILOMENA +7 more
openaire +5 more sources
Structure and mechanisms of the proteasome‐associated deubiquitinating enzyme USP14 [PDF]
The EMBO Journal, 2005 The ubiquitin-specific processing protease (UBP) family of deubiquitinating enzymes plays an essential role in numerous cellular processes. Mammalian USP14 (Ubp6 in yeast) is unique among known UBP enzymes in that it is activated catalytically upon specific association with the 26S proteasome.
Min, Hu +7 more
openaire +2 more sources
USP14 maintains HIF1-α stabilization via its deubiquitination activity in hepatocellular carcinoma
Cell Death and Disease, 2021 Hepatocellular carcinoma (HCC) is the most common visceral neoplasms with its heterogeneity and high rate of recurrence. HCC is characterized to be delayed diagnosis and the development of resistant disease.
Chi Lv +9 more
doaj +1 more source
The ataxia (axJ) mutation causes abnormal GABAA receptor turnover in mice [PDF]
, 2009 Ataxia represents a pathological coordination failure that often involves functional disturbances in cerebellar circuits. Purkinje cells (PCs) characterize the only output neurons of the cerebellar cortex and critically participate in regulating motor ...
Kneussel Matthias +46 more
core +2 more sources