Results 11 to 20 of about 20,666 (164)
Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling. [PDF]
Adv Sci (Weinh)Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Zha F +13 more
europepmc +2 more sources
Deubiquitinase USP38 Stabilizes PLK1 Expression to Boost DNA Damage Repair in Ovarian Cancer
Kaohsiung Journal of Medical SciencesOvarian cancer (OC) is one of the most prevalent and severe gynecological malignant tumors. DNA damage repair (DDR) is essential in maintaining genome stability.
Yuan Ma, Ying Li, Kai‐Li Li
doaj +2 more sources
The VCPIP1-UBE3A Deubiquitination-Ubiquitination Cascade Contributes to Castration-Resistant Prostate Cancer Progression. [PDF]
Adv Sci (Weinh)VCIPIP1 emerges as a molecular link between protein stability and prostate cancer progression. By deubiquitinating and stabilizing UBE3A, VCIPIP1 promotes p53 degradation and progression to castration‐resistant prostate cancer. Elevated VCIPIP1 expression is associated with shorter castration‐resistant prostate cancer–free survival, highlighting the ...
Lin F +9 more
europepmc +2 more sources
USP13: Multiple Functions and Target Inhibition
Frontiers in Cell and Developmental Biology, 2022 As a deubiquitination (DUB) enzyme, ubiquitin-specific protease 13 (USP13) is involved in a myriad of cellular processes, such as mitochondrial energy metabolism, autophagy, DNA damage response, and endoplasmic reticulum-associated degradation (ERAD), by
Xiaolong Li +11 more
doaj +1 more source
Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1
Life Science Alliance, 2018 Deubiquitination of FANCD2, FANCI, and PCNA by USP1 is essential for DNA repair signalling. Reconstitution of the system reveals that USP1-mediated specificity towards K561 of FANCD2 is directed by a unique sequence at USP1's N-terminus.
Connor Arkinson +3 more
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Frontiers in Oncology, 2022 Ubiquitin-specific peptidase 10 (USP10) is a member of the ubiquitin-specific protease family that removes the ubiquitin chain from ubiquitin-conjugated protein substrates.
Ziqi Ye +7 more
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The emerging role of Deubiquitinases (DUBs) in parasites: A foresight review
Frontiers in Cellular and Infection Microbiology, 2022 Before the discovery of the proteasome complex, the lysosomes with acidic proteases and caspases in apoptotic pathways were thought to be the only pathways for the degradation of damaged, unfolded, and aged proteins. However, the discovery of 26S and 20S
Prakash Kumar +4 more
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The Molecular Basis of Spinocerebellar Ataxia Type 7
Frontiers in Neuroscience, 2022 Spinocerebellar ataxia (SCA) type 7 (SCA7) is caused by a CAG trinucleotide repeat expansion in the ataxin 7 (ATXN7) gene, which results in polyglutamine expansion at the amino terminus of the ATXN7 protein.
Rituparna Goswami +12 more
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ATR-Mediated FANCI Phosphorylation Regulates Both Ubiquitination and Deubiquitination of FANCD2
Frontiers in Cell and Developmental Biology, 2020 DNA interstrand crosslinks (ICLs) are a physical barrier to replication and therefore toxic to cell viability. An important mechanism for the removal of ICLs is the Fanconi Anemia DNA repair pathway, which is initiated by mono-ubiquitination of FANCD2 ...
Winnie Tan +5 more
doaj +1 more source
PSMC3 promotes RNAi by maintaining AGO2 stability through USP14
Cellular & Molecular Biology Letters, 2022 Background Argonaute 2 (AGO2), the only protein with catalytic activity in the human Argonaute family, is considered as a key component of RNA interference (RNAi) pathway.
Yan Jia +7 more
doaj +1 more source