Results 11 to 20 of about 22,435 (241)
Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1 [PDF]
Life Science Alliance, 2018 Deubiquitination of FANCD2, FANCI, and PCNA by USP1 is essential for DNA repair signalling. Reconstitution of the system reveals that USP1-mediated specificity towards K561 of FANCD2 is directed by a unique sequence at USP1's N-terminus.
Connor Arkinson +3 more
doaj +2 more sources
Bacterial Interference of Ubiquitination and Deubiquitination [PDF]
Cell Host & Microbe, 2007 Ubiquitination and deubiquitination regulate several essential cellular processes such as protein degradation, cell-cycle progression, signaling, and DNA repair. Given the importance of these processes, it is not surprising that many microbes have developed the means to interfere with different stages of ubiquitin pathways to promote their survival and
Rytkönen, Anne, Holden, David W.
openaire +4 more sources
Deubiquitination in virus infection [PDF]
Virology, 2007 Post-translational modification of proteins and peptides by ubiquitin, a highly evolutionarily conserved 76 residue protein, and ubiquitin-like modifiers has emerged as a major regulatory mechanism in various cellular activities. Eukaryotic viruses are known to modulate protein ubiquitination to their advantage in various ways.
Lindner, H. A., Lindner, Holger A.
openaire +3 more sources
Biomedicines, 2023 Radiotherapy, a treatment method employing radiation to eradicate tumor cells and subsequently reduce or eliminate tumor masses, is widely applied in the management of numerous patients with tumors.
Mengyun Zhang, Yingjie Shao, Wendong Gu
doaj +2 more sources
, 2022 Supplementary Figure from TRAF4 Maintains Deubiquitination of Caveolin-1 to Drive Glioblastoma Stemness and Temozolomide ...
Huaile Wang (14958504) +12 more
core +8 more sources
Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling. [PDF]
Adv Sci (Weinh)Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Zha F +13 more
europepmc +2 more sources
PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer. [PDF]
Adv Sci (Weinh)USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Chen Y +7 more
europepmc +2 more sources
A method for assaying deubiquitinating enzymes [PDF]
Biological Procedures Online, 1998 A general method for the assay of deubiquitinating enzymes was described in detail using (125)I-labeled ubiquitin-fused alphaNH-MHISPPEPESEEEEEHYC (referred to as Ub-PESTc) as a substrate. Since the tyrosine residue in the PESTc portion of the fusion protein was almost exclusively radioiodinated under a mild labeling condition, such as using IODO-BEADS,
Lee Jae Il +6 more
openaire +3 more sources
USP13: Multiple Functions and Target Inhibition
Frontiers in Cell and Developmental Biology, 2022 As a deubiquitination (DUB) enzyme, ubiquitin-specific protease 13 (USP13) is involved in a myriad of cellular processes, such as mitochondrial energy metabolism, autophagy, DNA damage response, and endoplasmic reticulum-associated degradation (ERAD), by
Xiaolong Li +11 more
doaj +1 more source
, 2023 Deubiquitination is a reverse post-translational modification of ubiquitination and plays significant roles in various signal transduction cascades and protein stability.
Yaoqi Liu (1489525) +5 more
core +1 more source