Results 11 to 20 of about 19,734 (206)
Deubiquitination and Activation of the NLRP3 Inflammasome by UCHL5 in HCV-Infected Cells
Microbiology Spectrum, 2021 Chronic hepatitis C virus (HCV) infection induces liver inflammation that can lead to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Inflammation is the outcome of the action of proinflammatory cytokines and chemokines, including interleukin-1 ...
Akshaya Ramachandran +3 more
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A method for assaying deubiquitinating enzymes [PDF]
Biological Procedures Online, 1998 A general method for the assay of deubiquitinating enzymes was described in detail using (125)I-labeled ubiquitin-fused alphaNH-MHISPPEPESEEEEEHYC (referred to as Ub-PESTc) as a substrate. Since the tyrosine residue in the PESTc portion of the fusion protein was almost exclusively radioiodinated under a mild labeling condition, such as using IODO-BEADS,
Lee Jae Il +6 more
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USP13: Multiple Functions and Target Inhibition
Frontiers in Cell and Developmental Biology, 2022 As a deubiquitination (DUB) enzyme, ubiquitin-specific protease 13 (USP13) is involved in a myriad of cellular processes, such as mitochondrial energy metabolism, autophagy, DNA damage response, and endoplasmic reticulum-associated degradation (ERAD), by
Xiaolong Li +11 more
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Ubiquitination and Deubiquitination in Oral Disease [PDF]
International Journal of Molecular Sciences, 2021 Oral health is an integral part of the general health and well-being of individuals. The presence of oral disease is potentially indicative of a number of systemic diseases and may contribute to their early diagnosis and treatment. The ubiquitin (Ub) system has been shown to play a role in cellular immune response, cellular development, and programmed ...
Tsuchida, Sachio, Nakayama, Tomohiro
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Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1
Life Science Alliance, 2018 Deubiquitination of FANCD2, FANCI, and PCNA by USP1 is essential for DNA repair signalling. Reconstitution of the system reveals that USP1-mediated specificity towards K561 of FANCD2 is directed by a unique sequence at USP1's N-terminus.
Connor Arkinson +3 more
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Frontiers in Oncology, 2022 Ubiquitin-specific peptidase 10 (USP10) is a member of the ubiquitin-specific protease family that removes the ubiquitin chain from ubiquitin-conjugated protein substrates.
Ziqi Ye +7 more
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The emerging role of Deubiquitinases (DUBs) in parasites: A foresight review
Frontiers in Cellular and Infection Microbiology, 2022 Before the discovery of the proteasome complex, the lysosomes with acidic proteases and caspases in apoptotic pathways were thought to be the only pathways for the degradation of damaged, unfolded, and aged proteins. However, the discovery of 26S and 20S
Prakash Kumar +4 more
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The Molecular Basis of Spinocerebellar Ataxia Type 7
Frontiers in Neuroscience, 2022 Spinocerebellar ataxia (SCA) type 7 (SCA7) is caused by a CAG trinucleotide repeat expansion in the ataxin 7 (ATXN7) gene, which results in polyglutamine expansion at the amino terminus of the ATXN7 protein.
Rituparna Goswami +12 more
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Deubiquitinating enzymes as oncotargets
Oncotarget, 2015 Carcinogenesis is a complex process tightly regulated at multiple levels by post-translational modifications. Epigenetics plays a major role in cancer development, all stable changes to the gene expression process that are not a result of a direct change in the DNA code are described as epigenetics.
McClurg UL, Robson CN
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A Novel Type of Deubiquitinating Enzyme [PDF]
Journal of Biological Chemistry, 2003 A previous report from this laboratory described two novel proteins that have sequence similarity to A20, a negative regulator of NF-kappaB (Evans, P. C., Taylor, E. R., Coadwell, J., Heyninck, K., Beyaert, R., and Kilshaw, P. J. (2001) Biochem. J. 357, 617-623).
Paul C, Evans +9 more
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