mUbiSiDa: a comprehensive database for protein ubiquitination sites in mammals. [PDF]
PLoS ONE, 2014 MOTIVATION: Protein ubiquitination is one of the important post-translational modifications by attaching ubiquitin to specific lysine (K) residues in target proteins, and plays important regulatory roles in many cell processes.
Tong Chen +6 more
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Vaccines, 2021 K48-linked ubiquitination determining antigen degradation and the endosomal recruitments of p97 and Sec61 plays vital roles in dendritic cell (DC) cross-presentation.
Chun Fang Hu +4 more
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Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay [PDF]
, 2018 Supplementary data for Koszela et.al. Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay, BMC Biology, 2018See README.txt ...
Sicheri, Frank +9 more
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Cell Research, 2016 Protein ubiquitination is a dynamic multifaceted post-translational modification involved in nearly all aspects of eukaryotic biology. Once attached to a substrate, the 76-amino acid protein ubiquitin is subjected to further modifications, creating a multitude of distinct signals with distinct cellular outcomes, referred to as the 'ubiquitin code ...
Kirby N Swatek, David Komander
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Quantitative proteomics reveals extensive lysine ubiquitination in the Arabidopsis root proteome and uncovers novel transcription factor stability states [PDF]
, 2021 Protein activity, abundance, and stability can be regulated by posttranslational modification including ubiquitination. Ubiquitination is conserved among eukaryotes and plays a central role in modulating cellular function and yet we lack comprehensive ...
Pu, Yunting +6 more
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A versatile plasmid system for reconstitution and analysis of mammalian ubiquitination cascades in yeast [PDF]
, 2017 Ubiquitination is a posttranslational protein modification that regulates most aspects of cellular life. The sheer number of ubiquitination enzymes that are present in a mammalian cell, over 700 in total, has thus far hampered the analysis of distinct ...
Rossella Avagliano Trezza +3 more
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Investigation of the auto-ubiquitination and ubiquitination potentials of Retinoblastoma binding protein 6 and its binding to p53 [PDF]
, 2019 >Magister Scientiae - MScRetinoblastoma Binding Protein 6 (RBBP6) is a 200 kDa human protein known to play an essential role in mRNA 3’-end processing, as well as functioning as an E3 ligase to catalyze ubiquitination and suppression of p53 and other ...
Simons, Taskeen
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Ubiquitin-specific protease USP25 functions in endoplasmic reticulum-associated degradation [PDF]
, 2012 Endoplasmic Reticulum (ER)-associated degradation (ERAD) discards abnormal proteins synthesized in the ER. Through coordinated actions of ERAD components, misfolded/anomalous proteins are recognized, ubiquitinated, extracted from the ER and ultimately ...
Amanda Denuc +14 more
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, 2011 In this chapter, we describe a method for detecting the ubiquitination status of G protein-coupled receptors (GPCRs). This involves co-expression of a GPCR with an epitope-tagged ubiquitin construct in a -heterologous mammalian expression system. Stimulus-dependent modification of the GPCR by -ubiquitin is detected by immunoprecipitation and subsequent
Adriana, Caballero, Adriano, Marchese
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Mechanisms of mono- and poly-ubiquitination: Ubiquitination specificity depends on compatibility between the E2 catalytic core and amino acid residues proximal to the lysine [PDF]
, 2010 Ubiquitination involves the attachment of ubiquitin to lysine residues on substrate proteins or itself, which can result in protein monoubiquitination or polyubiquitination. Ubiquitin attachment to different lysine residues can generate diverse substrate-
Boris Sarcevic +7 more
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