Results 41 to 50 of about 191,822 (309)
Ubiquitinome Profiling Reveals the Landscape of Ubiquitination Regulation in Rice Young Panicles
Genomics, Proteomics & Bioinformatics, 2020 Ubiquitination, an essential post-transcriptional modification (PTM), plays a vital role in nearly every biological process, including development and growth.
Liya Zhu +9 more
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Regulation of ubiquitin and ubiquitin‐like modifiers by phosphorylation [PDF]
The FEBS Journal, 2021 The regulatory influence of ubiquitin is vast, encompassing all cellular processes, by virtue of its central roles in protein degradation, membrane trafficking, and cell signaling. But how does ubiquitin, a 76 amino acid peptide, carry out such diverse, complex functions in eukaryotic cells? Part of the answer is rooted in the high degree of complexity
Nathaniel L. Hepowit +4 more
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Cells, 2022 Epigenetic regulation plays an essential role in driving precise transcriptional programs during development and homeostasis. Among epigenetic mechanisms, histone mono-ubiquitination has emerged as an important post-transcriptional modification.
Liat Oss-Ronen, Tzlil Sarusi, Idan Cohen
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βTrCP-mediated proteolysis of NF-kB1 p105 requires phosphorylation of p105 serines 927 and 932 [PDF]
, 2003 This work was supported by the U.K. Medical Research Council, the Arthritis Research Campaign (project grant L0536 to V.L.), and the AINP consortium, EC—5th framework.NF-κB1 p105 functions both as a precursor of NF-κB1 p50 and as a cytoplasmic inhibitor ...
Ben-Neriah, Yinon +9 more
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Multiple C-terminal Lysine residues target p53 for ubiquitin-proteasome-mediated degradation [PDF]
, 2000 This work was supported by the Medical Research Council, the Biotechnology and Biological Research Council, and the Cancer Research Campaign. D.P.L. is a Gibb fellow of the Cancer Research Campaign.In normal cells, p53 is maintained at a low level by ...
Lain, Sonia +6 more
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International Journal of Molecular Sciences, 2018 Ever since the discovery of ubiquitin in 1975[...]
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Functional Diversity and Structural Disorder in the Human Ubiquitination Pathway [PDF]
, 2013 The ubiquitin-proteasome system plays a central role in cellular regulation and protein quality control (PQC). The system is built as a pyramid of increasing complexity, with two E1 (ubiquitin activating), few dozen E2 (ubiquitin conjugating) and several
Mainak Guharoy +15 more
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SKP2 and OTUD1 govern non-proteolytic ubiquitination of YAP that promotes YAP nuclear localization and activity [PDF]
, 2018 Dysregulation of signaling pathways that control organ size, such as the AKT-mTOR and Hippo-YAP pathways, often leads to tumorigenesis and metastasis. The Hippo pathway effector YAP is a transcriptional co-activator overexpressed or activated in human ...
Fan Yao, Yutong Sun, Zhenna Xiao, Li Ma
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HIV Nef-mediated Ubiquitination of BCL2: Implications in Autophagy and Apoptosis
Frontiers in Immunology, 2021 Ubiquitination is a process that acts upon every step of the HIV replication cycle. The activity, subcellular localization, and stability of HIV dependency factors as well as negative modulators can be affected by ubiquitination.
Sergio Castro-Gonzalez +5 more
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TARGETING UBIQUITINATION MACHINERY FOR THE RESCUE OF THE F508del-CFTR [PDF]
, 2023 reservedCystic Fibrosis (CF) is a fatal, inherited disease caused by loss-of-function mutations in the Cystic Fibrosis transmembrane conductance regulator (CFTR), a chloride channel expressed in epithelial cells of various organs.
KHASKHELI, HAMEER KHAN
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