Results 41 to 50 of about 39,029 (256)

Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay

, 2018
Supplementary data for Koszela et.al. Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay, BMC Biology, 2018See README.txt ...
Sicheri, Frank, Auer, Manfred, Evans, David, Perez-Pi, Irene, Ceccarelli, Derek F J, Mann, Stefan, Tyers, Mike, Pham, Nhan T, Shave, Steven, Koszela, Joanna   +9 more
core   +1 more source

Ubiquitin System [PDF]

International Journal of Molecular Sciences, 2018
Ever since the discovery of ubiquitin in 1975[...]
openaire   +2 more sources

Ubiquitination in Health and Diseases [PDF]

, 2021
Ubiquitination is a biological process mediated by ubiquitin itself, the E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme, E3 ubiquitin ligase, and deubiquitinating enzyme, respectively.

core   +2 more sources

The seven human coronavirus main proteases exhibit differential modulation of NF-κB suppression via TAB1 cleavage

Communications Biology
The divergence in pathogenicity among human coronaviruses (HCoVs), from causing common cold to lethal pneumonia, may indicate distinct viral immune evasion strategies.
Xinming Fu, Dan Cao, Huan Zhou, Hao Huang   +3 more
doaj   +1 more source

HIV Nef-mediated Ubiquitination of BCL2: Implications in Autophagy and Apoptosis

Frontiers in Immunology, 2021
Ubiquitination is a process that acts upon every step of the HIV replication cycle. The activity, subcellular localization, and stability of HIV dependency factors as well as negative modulators can be affected by ubiquitination.
Sergio Castro-Gonzalez, Sydney Simpson, Yuhang Shi, Yuexuan Chen, Jared Benjamin, Ruth Serra-Moreno   +5 more
doaj   +1 more source

Analysis of Flagellar Protein Ubiquitination

, 2013
Flagella/cilia are conserved organelles existing in unicellular protists and multicellular animals, where they perform essential motile and sensory functions.
Huan Long, Huang, KY, Kaiyao Huang, Long, H   +3 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

ISGylation prevents autophagic degradation of STING and promotes antitumor immunity in lung cancer

Cell Death and Disease
The STING pathway plays a central role in immune activation; however, STING protein levels decline during the progression of various cancers, including lung cancer, thereby limiting the efficacy of immunotherapies.
Dan Cao, Bin Huang, Xinming Fu, Ming Liu, Xiaogang Niu, Hongbin Zhai, Hao Huang   +6 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Ubiquitination-Linked Phosphorylation of the FANCI S/TQ Cluster Contributes to Activation of the Fanconi Anemia I/D2 Complex

Cell Reports, 2017
Summary: Repair of interstrand crosslinks by the Fanconi anemia (FA) pathway requires both monoubiquitination and de-ubiquitination of the FANCI/FANCD2 (FANCI/D2) complex.
Ronald S. Cheung, Maria Castella, Antonio Abeyta, Philip R. Gafken, Nyka Tucker, Toshiyasu Taniguchi   +5 more
doaj   +1 more source