Comprehensive characterization of ubiquitinome of human colorectal cancer and identification of potential survival-related ubiquitination [PDF]
Journal of Translational Medicine, 2022 Background According to the Global Cancer Statistics in 2020, the incidence and mortality of colorectal cancer (CRC) rank third and second among all tumors.
Liewen Lin, Jingquan He, Wanxia Cai
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Proteome and ubiquitinome analyses of the brain cortex in K18-hACE2 mice infected with SARS-CoV-2 [PDF]
IScienceSummary: Clinical research indicates that SARS-CoV-2 infection is linked to several neurological consequences, and the virus is still spreading despite the availability of vaccinations and antiviral medications. To determine how hosts respond to SARS-CoV-
Qiaochu Wang +2 more
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Proteome and Ubiquitinome Analyses Reveal the Involvement of Ubiquitination in Resistance to Maize Lethal Necrosis [PDF]
Molecular Plant PathologyThis study analysed the proteome and ubiquitinome of SCMV‐ and/or MCMV‐infected maize plants and demonstrated the role of ZmGOX1 in the maize response to viral infections. ABSTRACT The co‐infection of maize chlorotic mottle virus (MCMV) and sugarcane mosaic virus (SCMV) causes maize lethal necrosis (MLN), which seriously affects the yield and quality ...
Huiyan Guo, Xinran Gao, Kaiqiang Hao
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Ubiquitinome Profiling Reveals the Landscape of Ubiquitination Regulation in Rice Young Panicles
Genomics, Proteomics and Bioinformatics, 2020 Ubiquitination, an essential post-transcriptional modification (PTM), plays a vital role in nearly every biological process, including development and growth.
Liya Zhu, Han Cheng, Guoqing Peng
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Comparative ubiquitinome analysis reveals the roles of protein ubiquitination in the heat stress response from Metarhizium robertsii [PDF]
Applied and Environmental MicrobiologyProtein ubiquitination plays a vital role in the stress response of diverse filamentous fungi. However, few reports are available on fungal insect pathogens, including Metarhizium.
Jueping Song +5 more
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Insights into the protein ubiquitinome in the host‒pathogen interplay during Mycobacterium tuberculosis infection [PDF]
Frontiers in Molecular BiosciencesMycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis capable of manipulating and circumventing the host’s immune system to establish infection.
Qishun Feng +6 more
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Light‐Activatable Ubiquitin for Studying Linkage‐Specific Ubiquitin Chain Formation Kinetics [PDF]
Advanced ScienceUbiquitination is a dynamic post‐translational modification governing protein abundance, function, and localization in eukaryotes. The Ubiquitin protein is conjugated to lysine residues of target proteins, but can also repeatedly be ubiquitinated itself,
Sudakshina Banerjee +7 more
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Ubiquitinome Analysis Uncovers Alterations in Synaptic Proteins and Glucose Metabolism Enzymes in the Hippocampi of Adolescent Mice Following Cold Exposure [PDF]
CellsCold exposure exerts negative effects on hippocampal nerve development in adolescent mice, but the underlying mechanisms are not fully understood. Given that ubiquitination is essential for neurodevelopmental processes, we attempted to investigate the ...
Xin－Yue Li, Qian-Ru Li, Shize Li
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Insights into ubiquitinome dynamics in the host‒pathogen interplay during Francisella novicida infection [PDF]
Cell Communication and SignalingUbiquitination functions as an important posttranslational modification for orchestrating inflammatory immune responses and cell death during pathogenic infection.
Luyu Yang +4 more
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Frontiers in Microbiology, 2022 Herpes simplex virus 1 (HSV-1) can productively infect multiple cell types and establish latent infection in neurons. Infected cell protein 0 (ICP0) is an HSV-1 E3 ubiquitin ligase crucial for productive infection and reactivation from latency.
Fujun Hou, Zeyu Sun, Xiyuan Yang
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