Results 1 to 10 of about 61 (53)

Interactome and Ubiquitinome Analyses Identify Functional Targets of Herpes Simplex Virus 1 Infected Cell Protein 0

Frontiers in Microbiology, 2022
Herpes simplex virus 1 (HSV-1) can productively infect multiple cell types and establish latent infection in neurons. Infected cell protein 0 (ICP0) is an HSV-1 E3 ubiquitin ligase crucial for productive infection and reactivation from latency.
Dongli Pan, Zeyu Sun, Xiyuan Yang
exaly   +3 more sources

Ubiquitinome Profiling Reveals the Landscape of Ubiquitination Regulation in Rice Young Panicles

Genomics, Proteomics and Bioinformatics, 2020
Ubiquitination, an essential post-transcriptional modification (PTM), plays a vital role in nearly every biological process, including development and growth.
Erdong Ni, Wang Shuansuo, Peng Guoqing   +2 more
exaly   +3 more sources

Comprehensive characterization of ubiquitinome of human colorectal cancer and identification of potential survival-related ubiquitination

Journal of Translational Medicine, 2022
Background According to the Global Cancer Statistics in 2020, the incidence and mortality of colorectal cancer (CRC) rank third and second among all tumors.
Wanxia Cai, Yong Dai, Jingquan He
exaly   +2 more sources

A targeted multi-proteomics approach generates a blueprint of the ciliary ubiquitinome

Frontiers in Cell and Developmental Biology, 2023
Establishment and maintenance of the primary cilium as a signaling-competent organelle requires a high degree of fine tuning, which is at least in part achieved by a variety of post-translational modifications.
Katrin Junger, Van Beersum Sylvia E C
exaly   +3 more sources

Insights into the protein ubiquitinome in the host‒pathogen interplay during Mycobacterium tuberculosis infection

Frontiers in Molecular Biosciences
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis capable of manipulating and circumventing the host’s immune system to establish infection.
Guoxin Huang, Guoliang Zhang
exaly   +3 more sources

Comparative ubiquitinome analysis reveals the roles of protein ubiquitination in the heat stress response from Metarhizium robertsii

Applied and Environmental Microbiology
Protein ubiquitination plays a vital role in the stress response of diverse filamentous fungi. However, few reports are available on fungal insect pathogens, including Metarhizium.
Jueping Song, Ali Raza, Hanyuan Chen, Guangshuo Li, Bo Huang, Zhangxun Wang   +5 more
exaly   +3 more sources

Ubiquitinome Analysis Uncovers Alterations in Synaptic Proteins and Glucose Metabolism Enzymes in the Hippocampi of Adolescent Mice Following Cold Exposure

Cells
Cold exposure exerts negative effects on hippocampal nerve development in adolescent mice, but the underlying mechanisms are not fully understood. Given that ubiquitination is essential for neurodevelopmental processes, we attempted to investigate the ...
Shize Li, Huanmin Yang, Jingjing Lu
exaly   +3 more sources

Time-resolved in vivo ubiquitinome profiling by DIA-MS reveals USP7 targets on a proteome-wide scale

Nature Communications, 2021
Combining improved sample preparation, data-independent acquisition mass spectrometry and deep learning, the authors develop a workflow for more robust and precise quantitative ubiquitinome profiling.
Martin Steger, Vadim Demichev, Mattias Backman, Uli Ohmayer, Phillip Ihmor, Stefan Müller, Markus Ralser, Henrik Daub   +7 more
doaj   +1 more source

Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology

Nature Communications, 2021
Protein ubiquitylation is often studied by proteomics but how data independent acquisition (DIA) may advance these studies remains to be explored. Here, the authors show that DIA improves ubiquitylation site identification and quantification, enabling ...
Fynn M. Hansen, Maria C. Tanzer, Franziska Brüning, Isabell Bludau, Che Stafford, Brenda A. Schulman, Maria S. Robles, Ozge Karayel, Matthias Mann   +8 more
doaj   +1 more source

Integrative Proteomic Analysis of Multiple Posttranslational Modifications in Inflammatory Response

Genomics, Proteomics & Bioinformatics, 2022
Posttranslational modifications (PTMs) of proteins, particularly acetylation, phosphorylation, and ubiquitination, play critical roles in the host innate immune response. PTMs’ dynamic changes and the crosstalk among them are complicated.
Feiyang Ji, Menghao Zhou, Huihui Zhu, Zhengyi Jiang, Qirui Li, Xiaoxi Ouyang, Yiming Lv, Sainan Zhang, Tian Wu, Lanjuan Li   +9 more
doaj   +1 more source