Results 1 to 10 of about 206,681 (262)

NPC1 controls TGFBR1 stability in a cholesterol transport-independent manner and promotes hepatocellular carcinoma progression

Nature Communications
Niemann-Pick disease type C protein 1 (NPC1), classically associated with cholesterol transport and viral entry, has an emerging role in cancer biology.
Shuangyan Li, Lishan Yan, Chaoying Li, Lijuan Lou, Fengjiao Cui, Xiao Yang, Fuchu He, Ying Jiang   +7 more
doaj   +1 more source

Plasma Proteome Database as a resource for proteomics research

PROTEOMICS, 2005
AbstractPlasma is one of the best studied compartments in the human body and serves as an ideal body fluid for the diagnosis of diseases. This report provides a detailed functional annotation of all the plasma proteins identified to date. In all, gene products encoded by 3778 distinct genes were annotated based on proteins previously published in the ...
Muthusamy, Babylakshmi, Hanumanthu, G., Suresh, Shubha, Rekha, B., Srinivas, D., Karthick, L., Vrushabendra, B. M., Sharma, Salil, Mishra, Goparani, Chatterjee, Pritam, Mangala, K. S., Nagaraj, Shivashankar H., Chandrika, K. N., Deshpande, Nandan, Suresh, M., Kannabiran, N., Niranjan, Vidya, Nalli, Anuradha, Prasad, T. S. Keshava, Arun, K. S., Reddy, Raghunath, Chandran, Sreenath, Jadhav, Trafina, Julie, D., Mahesh, M., John, S. Lynate, Palvankar, Kshitish, Sudhir, D., Bala, P., Rashmi, N. S., Vishnupriya, G., Dhar, Kaushik, Reshma, S., Chaerkady, Raghothama, Gandhi, T. K. B., Harsha, H. C., Mohan, S. Sujatha, Deshpande, Krishna S., Sarker, Malabika, Pandey, Akhilesh   +39 more
openaire   +5 more sources

A protein sequence-based deep transfer learning framework for identifying human proteome-wide deubiquitinase-substrate interactions

Nature Communications
Protein ubiquitination regulates a wide range of cellular processes. The degree of protein ubiquitination is determined by the delicate balance between ubiquitin ligase (E3)-mediated ubiquitination and deubiquitinase (DUB)-mediated deubiquitination.
Yuan Liu, Dianke Li, Xin Zhang, Simin Xia, Yingjie Qu, Xinping Ling, Yang Li, Xiangren Kong, Lingqiang Zhang, Chun-Ping Cui, Dong Li   +10 more
doaj   +1 more source

Nuclear and cytoplasmic specific RNA binding proteome enrichment and its changes upon ferroptosis induction

Nature Communications
The key role of RNA-binding proteins (RBPs) in posttranscriptional regulation of gene expression is intimately tied to their subcellular localization. Here, we show a subcellular-specific RNA labeling method for efficient enrichment and deep profiling of
Haofan Sun, Bin Fu, Xiaohong Qian, Ping Xu, Weijie Qin   +4 more
doaj   +1 more source

An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network

Nature Communications, 2017
Protein stability modulation by E3 ubiquitin ligases is an important layer of functional regulation, but screening for E3 ligase-substrate interactions is time-consuming and costly.
Yang Li, Ping Xie, Liang Lu, Jian Wang, Lihong Diao, Zhongyang Liu, Feifei Guo, Yangzhige He, Yuan Liu, Qin Huang, Han Liang, Dong Li, Fuchu He   +12 more
doaj   +1 more source

Regulation of lipoprotein processing by GPNMB in foamy macrophages: potential therapeutic targets for atherosclerosis

Nature Communications
The formation of foamy macrophages is often considered a pathological hallmark of atherosclerosis, but the underlying mechanisms remain elusive. Herein, we demonstrated that the transcription factor TFEC could upregulate the expression of Glycoprotein ...
Junqi Wang, Liming Peng, Huan Wang, Di Liu, Wenting Yang, Fang Yan, Dianyuan Zhao, Chunhua Zhang, Ziliang He, Xiao-Ping Chen, Li Tang   +10 more
doaj   +1 more source

Genome-wide association study identifies 8p21.3 associated with persistent hepatitis B virus infection among Chinese

Nature Communications, 2016
This genome-wide association study on persistent hepatitis B virus (HBV) infection among Chinese confirms previously associated genetic loci while discovering a novel protective locus at 8p21.3.
Yuanfeng Li, Lanlan Si, Yun Zhai, Yanling Hu, Zhibin Hu, Jin-Xin Bei, Bobo Xie, Qian Ren, Pengbo Cao, Fei Yang, Qingfeng Song, Zhiyu Bao, Haitao Zhang, Yuqing Han, Zhifu Wang, Xi Chen, Xia Xia, Hongbo Yan, Rui Wang, Ying Zhang, Chengming Gao, Jinfeng Meng, Xinyi Tu, Xinqiang Liang, Ying Cui, Ying Liu, Xiaopan Wu, Zhuo Li, Huifen Wang, Zhaoxia Li, Bo Hu, Minghui He, Zhibo Gao, Xiaobing Xu, Hongzan Ji, Chaohui Yu, Yi Sun, Baocai Xing, Xiaobo Yang, Haiying Zhang, Aihua Tan, Chunlei Wu, Weihua Jia, Shengping Li, Yi-Xin Zeng, Hongbing Shen, Fuchu He, Zengnan Mo, Hongxing Zhang, Gangqiao Zhou   +49 more
doaj   +1 more source

Proteomics [PDF]

Journal of Biomedicine and Biotechnology, 2010
Garcia, Benjamin A., Cooper, Helen J., Dorrestein, Pieter C., Tang, Kai, Ueberheide, Beatrix M.   +4 more
openaire   +2 more sources

Proteomics [PDF]

Nature Biotechnology, 2019
openaire   +2 more sources

BRISC inactivation alleviates alcohol-induced liver injury in mice

Scientific Reports
BRCC3 isopeptidase complex (BRISC) is a JAMM subfamily deubiquitinase that has been revealed to be required for optional activation of NLRP3 inflammasome and TLR4/NF-κB signaling pathway.
Ting Wang, Wen Zhang, Xian Liu, Kai Liu, Guang-Ming Ren, Shen-Si Xiang, Yi-Qun Zhan, Hui Chen, Hui-Ying Gao, Ke Zhao, Miao Yu, Chang-Yan Li, Xiao-Ming Yang, Rong-Hua Yin   +13 more
doaj   +1 more source