Results 21 to 30 of about 299,370 (300)

BRISC is required for optimal activation of NF-κB in Kupffer cells induced by LPS and contributes to acute liver injury

Cell Death and Disease, 2023
BRISC (BRCC3 isopeptidase complex) is a deubiquitinating enzyme that has been linked with inflammatory processes, but its role in liver diseases and the underlying mechanism are unknown. Here, we investigated the pathophysiological role of BRISC in acute
Wen Zhang, Kai Liu, Guang-Ming Ren, Yu Wang, Ting Wang, Xian Liu, Dong-Xu Li, Yang Xiao, Xu Chen, Ya-Ting Li, Yi-Qun Zhan, Shen-Si Xiang, Hui Chen, Hui-Ying Gao, Ke Zhao, Miao Yu, Chang-Hui Ge, Chang-Yan Li, Zhi-Qiang Ge, Xiao-Ming Yang, Rong-Hua Yin   +20 more
doaj   +1 more source

Extensive mass spectrometry-based analysis of the fission yeast proteome: the Schizosaccharomyces pombe PeptideAtlas [PDF]

, 2013
We report a high quality and system-wide proteome catalogue covering 71% (3,542 proteins) of the predicted genes of fission yeast, Schizosaccharomyces pombe, presenting the largest protein dataset to date for this important model organism.
Schmidt, A, Lössner, C, Gunaratne, J, Blackstock, W, Xia, Rachel Li Hai, Ahrné, Erik, Quandt, A, Neo, Suat Peng, Saraç, OS, Gracia, Tannia, Gracia, T, Xia, RL, Bähler, J, Bähler, Jürg, Tan, KH, Tan, Keng Hwa, Aebersold, Ruedi, Beyer, A, Beyer, Andreas, Loguercio, Salvatore, Quandt, Andreas, Gunaratne, Jayantha, Aebersold, R, Blackstock, Walter, Loguercio, S, Saraç, Omer Sinan, Neo, SP, Schmidt, Alexander, Ahrné, E, Lössner, Christopher   +29 more
core   +1 more source

Toward an understanding of the protein interaction network of the human liver

Molecular Systems Biology, 2011
Proteome‐scale protein interaction maps are available for many organisms, ranging from bacteria, yeast, worms and flies to humans. These maps provide substantial new insights into systems biology, disease research and drug discovery.
Jian Wang, Keke Huo, Lixin Ma, Liujun Tang, Dong Li, Xiaobi Huang, Yanzhi Yuan, Chunhua Li, Wei Wang, Wei Guan, Hui Chen, Chaozhi Jin, Junchen Wei, Wanqiao Zhang, Yongsheng Yang, Qiongming Liu, Ying Zhou, Cuili Zhang, Zhihao Wu, Wangxiang Xu, Ying Zhang, Tao Liu, Donghui Yu, Yaping Zhang, Liang Chen, Dewu Zhu, Xing Zhong, Lixin Kang, Xiang Gan, Xiaolan Yu, Qi Ma, Jing Yan, Li Zhou, Zhongyang Liu, Yunping Zhu, Tao Zhou, Fuchu He, Xiaoming Yang   +37 more
doaj   +1 more source

Redox Proteomics [PDF]

Antioxidants & Redox Signaling, 2012
Proteins are major targets of reactive oxygen and nitrogen species (ROS/RNS) and numerous post-translational, reversible or irreversible modifications have been characterized, which may lead to a change in the structure and/or function of the oxidized protein.
D. A. Butterfield, I. Dalle-Donne
openaire   +2 more sources

Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair

Nature Communications, 2019
Neutrophils and macrophages are both involved in the initiation of inflammation, but whether and how they may participate in inflammation resolution is unclear.
Wenting Yang, Yuandong Tao, Yan Wu, Xinyuan Zhao, Weijie Ye, Dianyuan Zhao, Ling Fu, Caiping Tian, Jing Yang, Fuchu He, Li Tang   +10 more
doaj   +1 more source

OsteoporosAtlas: a human osteoporosis-related gene database [PDF]

PeerJ, 2019
Background Osteoporosis is a common, complex disease of bone with a strong heritable component, characterized by low bone mineral density, microarchitectural deterioration of bone tissue and an increased risk of fracture.
Xun Wang, Lihong Diao, Dezhi Sun, Dan Wang, Jiarun Zhu, Yangzhige He, Yuan Liu, Hao Xu, Yi Zhang, Jinying Liu, Yan Wang, Fuchu He, Yang Li, Dong Li   +13 more
doaj   +2 more sources

Proteoforms expand the world of microproteins and short open reading frame-encoded peptides

iScience, 2023
Summary: Microproteins and short open reading frame-encoded peptides (SEPs) can, like all proteins, carry numerous posttranslational modifications. Together with posttranscriptional processes, this leads to a high number of possible distinct protein ...
Liam Cassidy, Philipp T. Kaulich, Andreas Tholey   +2 more
doaj   +1 more source

Organelle Proteomics [PDF]

Current Protocols in Protein Science, 2006
AbstractThis unit describes strategies for studying the proteomes of organelles, which is one example of targeted proteomics. It relies heavily on previously published units dealing with organelle preparation, protein solubilization, and proteomics techniques. A specific commentary for organelle proteomics is provided.
Lescuyer, Pierre, Chevallet, Mireille, Luche, Sylvie, Rabilloud, Thierry   +3 more
openaire   +5 more sources

Intrinsic disorder in protein domains contributes to both organism complexity and clade-specific functions

Scientific Reports, 2021
Interestingly, some protein domains are intrinsically disordered (abbreviated as IDD), and the disorder degree of same domains may differ in different contexts.
Chao Gao, Chong Ma, Huqiang Wang, Haolin Zhong, Jiayin Zang, Rugang Zhong, Fuchu He, Dong Yang   +7 more
doaj   +1 more source

The 2023 Report on the Proteome from the HUPO Human Proteome Project. [PDF]

Since 2010, the Human Proteome Project (HPP), the flagship initiative of the Human Proteome Organization (HUPO), has pursued two ...
Van Eyk, Jennifer E, Aebersold, Ruedi,, Omenn, Gilbert S.,, Bandeira, Nuno,, Overall, Christopher M.,, Pineau, Charles,, Liu, Siqi,, Bandeira, Nuno, Van Eyk, Jennifer E.,, Weintraub, Susan T.,, Deutsch, Eric W.,, Cristea, Ileana M.,, Roehrl, Michael H. A.,, Orchard, Sandra,, Nice, Edouard,, Nice, Edouard, Liu, Siqi, Moritz, Robert L, Deutsch, Eric W, Omenn, Gilbert S, Lindskog, Cecilia, Cristea, Ileana M, Packer, Nicolle H.,, Roehrl, Michael HA, Guo, Tiannan, Aebersold, Ruedi, Lindskog, Cecilia,, Roehrl, Michael H A, Lane, Lydie,, Packer, Nicolle H, Overall, Christopher M, Weintraub, Susan T, Orchard, Sandra, Pineau, Charles, Guo, Tiannan,, et al., Lane, Lydie, Moritz, Robert L.,   +37 more
core   +1 more source