Results 21 to 30 of about 429,532 (300)

Predicting clinical outcome of neuroblastoma patients using an integrative network-based approach

Biology Direct, 2018
Background One of the main current challenges in computational biology is to make sense of the huge amounts of multidimensional experimental data that are being produced.
Léon-Charles Tranchevent, Petr V. Nazarov, Tony Kaoma, Georges P. Schmartz, Arnaud Muller, Sang-Yoon Kim, Jagath C. Rajapakse, Francisco Azuaje   +7 more
doaj   +1 more source

Conserved paradoxical relationships among the evolutionary, structural and expressional features of KRAB zinc-finger proteins reveal their special functional characteristics

BMC Molecular and Cell Biology, 2021
Background One striking feature of the large KRAB domain-containing zinc finger protein (KZFP) family is its rapid evolution, leading to hundreds of member genes with various origination time in a certain mammalian genome. However, a comprehensive genome-
Pan Shen, Aishi Xu, Yushan Hou, Huqiang Wang, Chao Gao, Fuchu He, Dong Yang   +6 more
doaj   +1 more source

Assessing the contribution of alternative splicing to proteome diversity in Arabidopsis thaliana using proteomics data [PDF]

, 2011
Background - Large-scale analyses of genomics and transcriptomics data have revealed that alternative splicing (AS) substantially increases the complexity of the transcriptome in higher eukaryotes.
Severing, E.I., Dijk, A.D.J., van, Ham, R.C.H.J., van   +2 more
core   +2 more sources

Proteomic overview of hepatocellular carcinoma cell lines and generation of the spectral library

Scientific Data, 2022
Measurement(s) Proteome of hepatocellular carcinoma cell lines Technology Type(s) Liquid chromatography-tandem mass spectrometry Sample Characteristic - Organism Homo ...
Mingchao Wang, Shuang Weng, Chaoying Li, Ying Jiang, Xiaohong Qian, Ping Xu, Wantao Ying   +6 more
doaj   +1 more source

Proteomic Analysis to Identify Tightly-Bound Cell Wall Protein in Rice Calli. [PDF]

, 2015
Rice is a model plant widely used for basic and applied research programs. Plant cell wall proteins play key roles in a broad range of biological processes. However, presently, knowledge on the rice cell wall proteome is rudimentary in nature.
Chen, Xiong Yan, Cho, Won Kyong, Hyun, Tae Kyung, Jo, Yeonhwa, Kim, Jae-Yean, Kim, Suwha, Kumar, Dhinesh, Lee, Keun Woo, Lucas, William J, Park, Zee-Yong, Rim, Yeonggil   +10 more
core   +1 more source

High-affinity SOAT1 ligands remodeled cholesterol metabolism program to inhibit tumor growth

BMC Medicine, 2022
Background Although cholesterol metabolism is a common pathway for the development of antitumor drugs, there are no specific targets and drugs for clinical use.
Zhihua Wang, Miaomiao Wang, Mengxin Zhang, Kaikun Xu, Xinshuai Zhang, Yi Xie, Yiming Zhang, Cheng Chang, Xiaolu Li, Aihua Sun, Fuchu He   +10 more
doaj   +1 more source

Salmonella Typhi, Paratyphi A, Enteritidis and Typhimurium core proteomes reveal differentially expressed proteins linked to the cell surface and pathogenicity [PDF]

, 2019
Background: Salmonella enterica subsp. enterica contains more than 2,600 serovars of which four are of major medical relevance for humans. While the typhoidal serovars (Typhi and Paratyphi A) are human-restricted and cause enteric fever, non-typhoidal ...
Barbé, Barbara, Deborggraeve, Stijn, Gevaert, Kris, Jacobs, Jan, Saleh, Sara, Staes, An, Timmerman, Evy, Van Puyvelde, Sandra   +7 more
core   +2 more sources

BRISC is required for optimal activation of NF-κB in Kupffer cells induced by LPS and contributes to acute liver injury

Cell Death and Disease, 2023
BRISC (BRCC3 isopeptidase complex) is a deubiquitinating enzyme that has been linked with inflammatory processes, but its role in liver diseases and the underlying mechanism are unknown. Here, we investigated the pathophysiological role of BRISC in acute
Wen Zhang, Kai Liu, Guang-Ming Ren, Yu Wang, Ting Wang, Xian Liu, Dong-Xu Li, Yang Xiao, Xu Chen, Ya-Ting Li, Yi-Qun Zhan, Shen-Si Xiang, Hui Chen, Hui-Ying Gao, Ke Zhao, Miao Yu, Chang-Hui Ge, Chang-Yan Li, Zhi-Qiang Ge, Xiao-Ming Yang, Rong-Hua Yin   +20 more
doaj   +1 more source

Pathway analysis and transcriptomics improve protein identification by shotgun proteomics from samples comprising small number of cells - a benchmarking study [PDF]

, 2014
BACKGROUND: Proteomics research is enabled with the high-throughput technologies, but our ability to identify expressed proteome is limited in small samples. The coverage and consistency of proteome expression are critical problems in proteomics.
Brusic, Vladimir, Fenyo, David, Ivanov, Alexander R., Karger, Barry L., Li, Siyang, Lisacek, Frederique, Murthy, Shashi K., Sun, Jing, Zhang, Guang Lan   +8 more
core   +5 more sources

Proteome Profiling of Breast Tumors by Gel Electrophoresis and Nanoscale Electrospray Ionization Mass Spectrometry [PDF]

, 2008
We have conducted proteome-wide analysis of fresh surgery specimens derived from breast cancer patients, using an approach that integrates size-based intact protein fractionation, nanoscale liquid separation of peptides, electrospray ion trap mass ...
Aebersold R., Boyle E. I., Chong P. K., Cottingham K., Cove D. H., Ezeh U. I., Foran E., Gygi S. P., Ioachim E., Jacobs J. M., Keller A., Laemmli U. K., Lapillonne A., Lin C. S., Liu H., Maclean B., Mathelin C., Metodiev M. V., old W. M., Patterson S. D., Pedrioli P. G., Rauch A., Schmidt A., Sealfon R. S., Seo J., Sheen-Cheen S. M., Silva J., Taylor M. R., Toi M., Wolters D. A., Zhang J.   +30 more
core   +1 more source