Results 31 to 40 of about 429,532 (300)

Toward an understanding of the protein interaction network of the human liver

open access: yesMolecular Systems Biology, 2011
Proteome‐scale protein interaction maps are available for many organisms, ranging from bacteria, yeast, worms and flies to humans. These maps provide substantial new insights into systems biology, disease research and drug discovery.
Jian Wang   +37 more
doaj   +1 more source

Proteoforms expand the world of microproteins and short open reading frame-encoded peptides

open access: yesiScience, 2023
Summary: Microproteins and short open reading frame-encoded peptides (SEPs) can, like all proteins, carry numerous posttranslational modifications. Together with posttranscriptional processes, this leads to a high number of possible distinct protein ...
Liam Cassidy   +2 more
doaj   +1 more source

Site-specific identification and quantitation of endogenous SUMO modifications under native conditions. [PDF]

open access: yes, 2017
Small ubiquitin-like modifier (SUMO) modification regulates numerous cellular processes. Unlike ubiquitin, detection of endogenous SUMOylated proteins is limited by the lack of naturally occurring protease sites in the C-terminal tail of SUMO proteins ...
Ahmad, Alla S   +8 more
core   +2 more sources

OsteoporosAtlas: a human osteoporosis-related gene database [PDF]

open access: yesPeerJ, 2019
Background Osteoporosis is a common, complex disease of bone with a strong heritable component, characterized by low bone mineral density, microarchitectural deterioration of bone tissue and an increased risk of fracture.
Xun Wang   +13 more
doaj   +2 more sources

Whole-proteome tree of life suggests a deep burst of organism diversity. [PDF]

open access: yes, 2020
An organism tree of life (organism ToL) is a conceptual and metaphorical tree to capture a simplified narrative of the evolutionary course and kinship among the extant organisms.
Choi, JaeJin, Kim, Sung-Hou
core  

Proteomics of industrial fungi: trends and insights for biotechnology [PDF]

open access: yes, 2010
Filamentous fungi are widely known for their industrial applications, namely, the production of food-processing enzymes and metabolites such as antibiotics and organic acids.
Oliveira, J.M., Graaff, L.H., de
core   +1 more source

Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair

open access: yesNature Communications, 2019
Neutrophils and macrophages are both involved in the initiation of inflammation, but whether and how they may participate in inflammation resolution is unclear.
Wenting Yang   +10 more
doaj   +1 more source

The proteostasis network and its decline in ageing

open access: yes, 2019
Ageing is a major risk factor for the development of many diseases, prominently including neurodegenerative disorders such as Alzheimer disease and Parkinson disease.
Hartl, F., Hipp, M., Kasturi, P.
core   +1 more source

solveME: fast and reliable solution of nonlinear ME models. [PDF]

open access: yes, 2016
BackgroundGenome-scale models of metabolism and macromolecular expression (ME) significantly expand the scope and predictive capabilities of constraint-based modeling.
Ebrahim, Ali   +5 more
core   +4 more sources

Platelet proteomics [PDF]

open access: yesJournal of Thrombosis and Haemostasis, 2003
As anucleate cell particles, platelets do not lend themselves to analysis by traditional cell and molecular biology techniques. Moreover, while valuable information may be gleaned from studies of messenger RNA in platelets, the rapid events in platelets are not governed by or dependent on alterations in gene expression.
P B, Maguire, D J, Fitzgerald
openaire   +2 more sources

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