Results 31 to 40 of about 289,844 (300)

The yeast vacuolar membrane proteome [PDF]

, 2009
Transport of solutes between the cytosol and the vacuolar lumen is of crucial importance for various functions of vacuoles, including ion homeostasis; detoxification; storage of different molecules such as amino acids, phosphate, and calcium ions; and ...
Poolman, Bert,, Slotboom, Dirk J.,, Breitling, Rainer, Permentier, Hjalmar P.,, Gandhi, Tejas, Breitling, R., Breitling, Rainer,, Slotboom, D.J., Gandhi, Tejas,, Permentier, Hjalmar P., Permentier, H.P., Gandhi, T., Wiederhold, Elena,, Poolman, Bert, Wiederhold, Elena, Wiederhold, E., Poolman, B., Permentier, Hjalmar P.; id_orcid, Slotboom, Dirk J.   +18 more
core   +3 more sources

Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair

Nature Communications, 2019
Neutrophils and macrophages are both involved in the initiation of inflammation, but whether and how they may participate in inflammation resolution is unclear.
Wenting Yang, Yuandong Tao, Yan Wu, Xinyuan Zhao, Weijie Ye, Dianyuan Zhao, Ling Fu, Caiping Tian, Jing Yang, Fuchu He, Li Tang   +10 more
doaj   +1 more source

OsteoporosAtlas: a human osteoporosis-related gene database [PDF]

PeerJ, 2019
Background Osteoporosis is a common, complex disease of bone with a strong heritable component, characterized by low bone mineral density, microarchitectural deterioration of bone tissue and an increased risk of fracture.
Xun Wang, Lihong Diao, Dezhi Sun, Dan Wang, Jiarun Zhu, Yangzhige He, Yuan Liu, Hao Xu, Yi Zhang, Jinying Liu, Yan Wang, Fuchu He, Yang Li, Dong Li   +13 more
doaj   +2 more sources

A two-level model for the role of complex and young genes in the formation of organism complexity and new insights into the relationship between evolution and development

EvoDevo, 2018
Background How genome complexity affects organismal phenotypic complexity is a fundamental question in evolutionary developmental biology. Previous studies proposed various contributing factors of genome complexity and tried to find the connection ...
Dong Yang, Aishi Xu, Pan Shen, Chao Gao, Jiayin Zang, Chen Qiu, Hongsheng Ouyang, Ying Jiang, Fuchu He   +8 more
doaj   +1 more source

Assessing the contribution of alternative splicing to proteome diversity in Arabidopsis thaliana using proteomics data [PDF]

, 2011
Background Large-scale analyses of genomics and transcriptomics data have revealed that alternative splicing (AS) substantially increases the complexity of the transcriptome in higher eukaryotes.
Dijk, A.D.J., van, van Dijk Aalt DJ, Severing, E.I., Roeland CHJ van Ham, Ham, R.C.H.J., van, van Dijk, A.D.J., van Ham, R.C.H.J., Severing Edouard I, Edouard I Severing, Aalt DJ van Dijk, van Ham Roeland CHJ   +10 more
core   +1 more source

GIT2 deficiency attenuates concanavalin A‐induced hepatitis in mice

FEBS Open Bio, 2015
G protein‐coupled receptor kinase interactor 2 (GIT2) is a signaling scaffold protein involved in regulation of cytoskeletal dynamics and the internalization of G protein‐coupled receptors (GPCRs). The short‐splice form of GIT2 is expressed in peripheral
Yu-E Hao, Dong-Fang He, Rong-Hua Yin, Hui Chen, Jian Wang, Shao-Xia Wang, Yi-Qun Zhan, Chang-Hui Ge, Chang-Yan Li, Miao Yu, Xiao-Ming Yang   +10 more
doaj   +1 more source

proteomics technologies: Probing the proteome [PDF]

Nature, 2003
The completion of the human genome sequence, coupled with analytical techniques such as mass spectrometry, has fuelled interest in proteomics. Diane Gershon reports.
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Proteomes: A New Proteomic Journal [PDF]

Proteomes, 2012
In the early years of proteomics, mass spectrometry served only as a technique in protein chemistry facilitating the characterization of purified proteins and mapping their posttranslational modifications (PTMs). A bit later this technique almost completely replaced Edman degradation and amino acid analysis.
openaire   +3 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source