Results 11 to 20 of about 299,370 (300)

Proteome-Wide Structural Probing of Low-Abundant Protein Interactions by Cross-Linking Mass Spectrometry

, 2020
Proteome-wide cross-linking studies have spurred great interest as they facilitate structural probing of protein interactions in living cells and organisms. However, current studies have a bias for high-abundant proteins.
Stefan G. Kreft (8462427), Julius Fürsch (8462421), Kai-Michael Kammer (8462424), Martin Beck (844357), Florian Stengel (428563)   +4 more
core   +6 more sources

The evolution of the plant organellar proteome [PDF]

, 2022
A hallmark of eukaryotic cells is the compartmentalisation of intracellular processes into specialised, membrane-bound compartments known as organelles. The function of organelles is dependent on a suite of proteins localised within them (the organellar ...
Costello, Rona Moira Oonagh
core   +1 more source

Defining the core proteome of the chloroplast envelope membranes [PDF]

, 2013
High-throughput protein localization studies require multiple strategies. Mass spectrometric analysis of defined cellular fractions is one of the complementary approaches to a diverse array of cell biological methods. In recent years, the protein content
Bernd Müller, Enrico eSchleiff, Mirus, Oliver, Stefan Simm, Michael Karas, Papasotiriou, Dimitrios, Papasotiriou, Dimitrios G., Dimitrios G. Papasotiriou, Schleiff, Enrico, Oliver Mirus, Bernd eMüller, Maik eSommer, Matthias S. Leisegang, Sommer, Maik Sascha, Maik S. Sommer, Dimitri ePapasotiriou, Stefan eSimm, Leisegang, Matthias S., Simm, Stefan, Mohamed eIbrahim, Oliver eMirus, Schorge, Tobias, Enrico Schleiff, Ibrahim, Mohamed, Matthias eLeisegang, Mohamed Ibrahim, Michael eKaras, Tobias Schorge, Müller, Bernd, Sommer, Maik S., Leisegang, Matthias, Tobias eSchorge, Karas, Michael   +32 more
core   +1 more source

Intricate Crosstalk Between Lipopolysaccharide, Phospholipid and Fatty Acid Metabolism in Escherichia coli Modulates Proteolysis of LpxC

Frontiers in Microbiology, 2019
Lipopolysaccharides (LPS) in the outer membrane of Gram-negative bacteria provide the first line of defense against antibiotics and other harmful compounds. LPS biosynthesis critically depends on LpxC catalyzing the first committed enzyme in this process.
Nikolas Thomanek, Jan Arends, Claudia Lindemann, Katalin Barkovits, Helmut E. Meyer, Helmut E. Meyer, Katrin Marcus, Franz Narberhaus   +7 more
doaj   +1 more source

Recent advances in CRISPR-based genome editing technology and its applications in cardiovascular research

Military Medical Research, 2023
The rapid development of genome editing technology has brought major breakthroughs in the fields of life science and medicine. In recent years, the clustered regularly interspaced short palindromic repeats (CRISPR)-based genome editing toolbox has been ...
Zhen-Hua Li, Jun Wang, Jing-Ping Xu, Jian Wang, Xiao Yang   +4 more
doaj   +1 more source

Nanotechnologies in Proteomics [PDF]

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Yuri D, Ivanov, Vadim M, Govorun, Victor A, Bykov, Alexander I, Archakov   +3 more
openaire   +2 more sources

Predicting clinical outcome of neuroblastoma patients using an integrative network-based approach

Biology Direct, 2018
Background One of the main current challenges in computational biology is to make sense of the huge amounts of multidimensional experimental data that are being produced.
Léon-Charles Tranchevent, Petr V. Nazarov, Tony Kaoma, Georges P. Schmartz, Arnaud Muller, Sang-Yoon Kim, Jagath C. Rajapakse, Francisco Azuaje   +7 more
doaj   +1 more source

Conserved paradoxical relationships among the evolutionary, structural and expressional features of KRAB zinc-finger proteins reveal their special functional characteristics

BMC Molecular and Cell Biology, 2021
Background One striking feature of the large KRAB domain-containing zinc finger protein (KZFP) family is its rapid evolution, leading to hundreds of member genes with various origination time in a certain mammalian genome. However, a comprehensive genome-
Pan Shen, Aishi Xu, Yushan Hou, Huqiang Wang, Chao Gao, Fuchu He, Dong Yang   +6 more
doaj   +1 more source

Proteomic overview of hepatocellular carcinoma cell lines and generation of the spectral library

Scientific Data, 2022
Measurement(s) Proteome of hepatocellular carcinoma cell lines Technology Type(s) Liquid chromatography-tandem mass spectrometry Sample Characteristic - Organism Homo ...
Mingchao Wang, Shuang Weng, Chaoying Li, Ying Jiang, Xiaohong Qian, Ping Xu, Wantao Ying   +6 more
doaj   +1 more source

High-affinity SOAT1 ligands remodeled cholesterol metabolism program to inhibit tumor growth

BMC Medicine, 2022
Background Although cholesterol metabolism is a common pathway for the development of antitumor drugs, there are no specific targets and drugs for clinical use.
Zhihua Wang, Miaomiao Wang, Mengxin Zhang, Kaikun Xu, Xinshuai Zhang, Yi Xie, Yiming Zhang, Cheng Chang, Xiaolu Li, Aihua Sun, Fuchu He   +10 more
doaj   +1 more source