Results 41 to 50 of about 662 (121)

Serpinc1 Acts as a Tumor Suppressor in Hepatocellular Carcinoma Through Inducing Apoptosis and Blocking Macrophage Polarization in an Ubiquitin-Proteasome Manner

Frontiers in Oncology, 2021
Serpinc1 is a serine protease inhibitor in the coagulation cascade, but its role in tumor biology remains obscure. Here, we report an unexpected role of serpinc1 in suppression of hepatocellular carcinoma (HCC).
Dacai Xu, Dacai Xu, Jiawen Wu, Liang Dong, Wenwen Luo, Lanying Li, Daolin Tang, Jinbao Liu   +7 more
doaj   +1 more source

Raw dataset for Integrated phosphoproteome, ubiquitinome, and acetylome analyses uncovering the post-translational modifications crosstalk during MSP1-induced signaling in rice

, 2023
Supplementary files related to the data article "Proteome analysis dataset of Post-Translational Modifications in MSP1-overexpressed rice"G.H. Lee,C.W. Min, J.W. Jang, G. Ravi, S.T. Kim.
Kim, S (via Mendeley Data)
core   +1 more source

Streptococcus pneumoniae and Influenza A Virus Co-Infection Induces Altered Polyubiquitination in A549 Cells

Frontiers in Cellular and Infection Microbiology, 2022
Epithelial cells are an important line of defense within the lung. Disruption of the epithelial barrier by pathogens enables the systemic dissemination of bacteria or viruses within the host leading to severe diseases with fatal outcomes.
Thomas Sura, Vanessa Gering, Clemens Cammann, Sven Hammerschmidt, Sandra Maaß, Ulrike Seifert, Dörte Becher   +6 more
doaj   +1 more source

ALS-linked loss of Cyclin-F function affects HSP90

Life Science Alliance, 2022
Analysis of ALS patient cell lines and cyclin-F overexpression and knockout cells identified HSP90AB1 as novel SCFcyclin-F substrate pointing to a loss-of-function mechanism for ALS CCNF mutations.
Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends   +3 more
doaj   +1 more source

Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates [PDF]

, 2022
The ubiquitin-proteasome axis has been extensively explored at a system-wide level, but the impact of deubiquitinating enzymes (DUBs) on the ubiquitinome remains largely unknown. Here, we compare the contributions of the proteasome and DUBs on the global
Akimov, V., Vertegaal, Alfred C. O., Shah, R.G., Blagoev, B., Overbeek, N. van, Shah, Rashmi G., Shah, G., Akimov, Vyacheslav, Trulsson, Fredrik, Robu, M., Blagoev, Blagoy, van Overbeek, N., van Overbeek, Nila, Shah, Girish M., Cox, J., Vertegaal, Alfred C O, Vertegaal, A.C.O., Trulsson, F., Vertegaal, A., Blagoev, Blagoy; id_orcid, Shah, G.M., Berrocal, D., Berrocal, David Aureliano Pérez, Cox, Jürgen, Shah, R., Berrocal, D.A.P., Shah, Rashmi G, Robu, Mihaela, Shah, Girish M   +28 more
core   +1 more source

Large-Scale Filter-Aided Sample Preparation Method for the Analysis of the Ubiquitinome

, 2017
Protein ubiquitination regulates key cellular functions, including protein homeostasis and signal transduction. The digestion of ubiquitinated proteins with trypsin yields a glycine–glycine remnant bound to the modified lysine residue (K-ε-GG) that can ...
Albert Casanovas (3842260), Casanovas, Albert, Pinto Llorente, Roberto, Carrascal, Montserrat, Abián, Joaquín, Roberto Pinto-Llorente (3842257), Montserrat Carrascal (213813), Joaquin Abian (213831)   +7 more
core   +1 more source

Table_1_Interactome and Ubiquitinome Analyses Identify Functional Targets of Herpes Simplex Virus 1 Infected Cell Protein 0.XLSX

, 2022
Herpes simplex virus 1 (HSV-1) can productively infect multiple cell types and establish latent infection in neurons. Infected cell protein 0 (ICP0) is an HSV-1 E3 ubiquitin ligase crucial for productive infection and reactivation from latency.
Siyu Chen (278663), Yue Deng (417668), Dongli Pan (2475040), Feiyang Ji (5393894), Fujun Hou (846435), Xiyuan Yang (12085906), Zeyu Sun (2932719), Keyi Ren (9182103), Menghao Zhou (12429843)   +8 more
core   +1 more source

Data_Sheet_1_Interactome and Ubiquitinome Analyses Identify Functional Targets of Herpes Simplex Virus 1 Infected Cell Protein 0.docx

, 2022
Herpes simplex virus 1 (HSV-1) can productively infect multiple cell types and establish latent infection in neurons. Infected cell protein 0 (ICP0) is an HSV-1 E3 ubiquitin ligase crucial for productive infection and reactivation from latency.
Siyu Chen (278663), Yue Deng (417668), Dongli Pan (2475040), Feiyang Ji (5393894), Fujun Hou (846435), Xiyuan Yang (12085906), Zeyu Sun (2932719), Keyi Ren (9182103), Menghao Zhou (12429843)   +8 more
core   +1 more source

Combined multiomics analysis reveals the mechanism of CENPF overexpression-mediated immune dysfunction in diffuse large B-cell lymphoma in vitro

Frontiers in Genetics, 2022
Diffuse large B-cell lymphoma (DLBCL) is one of the most common aggressive B-cell lymphomas with significant heterogeneity. More than half of patients are cured, but 40%–45% still face relapse or develop drug resistance, and the mechanism is not yet ...
Dan Yang, Jia Wang, Mingqiu Hu, Feng Li, Feifei Yang, Youcai Zhao, Yanli Xu, Xuezhong Zhang, Lijun Tang, Xiuqun Zhang   +9 more
doaj   +1 more source

Unveiling ubiquitinome rearrangements induced by salmonella infection

, 2016
Ubiquitination plays a critical role in the activation of host immune responses to infection and serves as a signal for pathogen delivery to phagophores along the xenophagy pathway.
Bionda, Tihana, Behrends, Christian
core   +1 more source