Results 51 to 60 of about 662 (121)

Improvement of ubiquitylation site detection by Orbitrap mass spectrometry [PDF]

, 2018
Ubiquitylation is an important posttranslational protein modification that is involved in many cellular events. Immunopurification of peptides containing a K-epsilon-diglycine (diGly) remnant as a mark of ubiquitylation combined with mass spectrometric ...
Rijkers, E, van der Wal, Lennart, Karel Bezstarosti, Elgersma, Ype, Mientjes, Edwin; id_orcid, Elgersma, Ype; id_orcid, Demmers, Jeroen A. A., Jeroen A.A. Demmers, Sap, Karen, Rijkers, Erikjan, Lennart van der Wal, Demmers, Jeroen, Mientjes, Edwin, Edwin Mientjes, Dekkers, Dick H. W., Dick H.W. Dekkers, Karen A. Sap, Erikjan Rijkers, Bezstarosti, Karel, Sap, Karen A., Ype Elgersma, Dekkers, Dick   +21 more
core   +4 more sources

The Analysis of the Ubiquitylomic Responses to Streptococcus agalactiae Infection in Bovine Mammary Gland Epithelial Cells

Journal of Inflammation Research, 2022
Jinjin Tong,1,* Xintong Ji,1,* Hua Zhang,1 Benhai Xiong,2 Defeng Cui,3 Linshu Jiang1 1Beijing Key Laboratory for Dairy Cow Nutrition, Beijing University of Agriculture, Beijing, People’s Republic of China; 2State Key Laboratory of Animal ...
Tong J, Ji X, Zhang H, Xiong B, Cui D, Jiang L   +5 more
doaj  

Molecular Glue Degraders in Early Development for Cancer Therapy

Medicinal Research Reviews, EarlyView.
ABSTRACT Molecular glue degraders are an emerging class of small molecule allosteric modulators that induce or stabilize protein‐protein interactions, enabling targeted degradation of previously intractable proteins. By redirecting E3 ligases to recognize neosubstrates, proteins that are not typically recognized by a specific E3 ubiquitin ligase, they ...
E. Sila Ozdemir, Hyunbum Jang, Ozlem Keskin, Attila Gursoy, Ruth Nussinov   +4 more
wiley   +1 more source

Deciphering the ubiquitin code by mass spectrometry [PDF]

, 2023
In this thesis we explore the Ubiquitin code using purification methods coupled with mass spectrometry. We overview the available methods and current knowledge of of Ubiquitin and SUMO modifications with examples of substrates where the precise site of ...
Trulsson, C.F.B.
core   +1 more source

Proteomic Characterization of AS1411 Reveals ATP6AP1 as a Mediator of Triple‐Negative Breast Cancer Progression

PROTEOMICS, Volume 26, Issue 7, Page 28-41, July 2026.
ABSTRACT Triple‐negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by high metastatic potential, poor prognosis, and limited effective therapeutic options. In this study, we investigated the molecular mechanisms underlying the anticancer effects of the nucleolin (NCL)‐targeting DNA aptamer AS1411 using label‐free ...
Ha‐Song Bae, Yun‐Jeong Seo, Eun‐Bi Kim, Hyoung‐Min Park, I‐Hsuan Liu, J. Eugene Lee, Jae‐Young Kim   +6 more
wiley   +1 more source

G4‐Ligand‐Directed PROTACs Unveil DR1 as a Novel Ligand‐Co‐Binding G4‐Protein and Reshape G4‐Dependent Transcription

Advanced Science, Volume 13, Issue 27, 13 May 2026.
G4‐binding proteins (G4BPs) that specifically co‐bind G4s in the presence of small‐molecule ligands represent a critical but unexplored class of proteins. We introduce G4‐Ligand‐Directed PROTACs (G4L‐TACs), a chemical platform that couples G4 ligands (PDS) to E3 recruiters to selectively degrade these ligand‐co‐binding G4BPs.
Mao‐Lin Li, Shu‐Min Xu, Xin‐Chen Jiang, Le‐Tian Dai, Yu‐Tao Hu, Kai‐Bo Wang, Jia‐Heng Tan, Zhi‐Shu Huang, Shuo‐Bin Chen   +8 more
wiley   +1 more source

The Ubiquitin Proteome of Toxoplasma gondii Reveals Roles for Protein Ubiquitination in Cell-Cycle Transitions [PDF]

, 2015
SummaryProtein ubiquitination plays key roles in protein turnover, cellular signaling, and intracellular transport. The genome of Toxoplasma gondii encodes ubiquitination machinery, but the roles of this posttranslational modification (PTM) are unknown ...
Bradley, Peter, Nieves, Edward, Yakubu, Rama, Weiss, Louis, Chen, Allan L., Silmon de Monerri, Natalie, Chen, Allan, Bradley, Peter J., Weiss, Louis M., Yakubu, Rama R., Silmon de Monerri, Natalie C., Kim, Kami   +11 more
core   +1 more source

Epigenetic regulation of mycorrhizal symbioses: from plastic responses to transgenerational legacies

New Phytologist, Volume 250, Issue 3, Page 1438-1452, May 2026.
Summary Mycorrhizal symbioses represent one of the most widespread and ecologically significant plant–microbe interactions, shaping plant nutrition, stress resilience, and ecosystem functioning. Beyond their role in nutrient exchange and systemic defense, growing evidence suggests that these symbioses also influence plant plasticity within and across ...
Gerson Beltrán‐Torres, Henry J. De La Cruz, Stéphane Maury, Martina Janoušková, Claire Veneault‐Fourrey, Vít Latzel, Pierre‐Emmanuel Courty, Harold Duruflé, Jörg Tost, Iris Sammarco   +9 more
wiley   +1 more source

Comprehensive analysis of the ubiquitinome during oncogene-induced senescence in human fibroblasts

, 2016
Oncogene-induced senescence (OIS) is an important tumor suppression mechanism preventing uncontrolled proliferation in response to aberrant oncogenic signaling.
Hsin-Yao Tang (395357), Hengrui Zhu (704478), Zhigang Tu (704477), David W Speicher (9078760), Rugang Zhang (395360), Fee Bengsch (704476)   +5 more
core   +1 more source

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, Volume 13, Issue 19, 2 April 2026.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source