Results 51 to 60 of about 543 (120)

Ubiquitinome Profiling Reveals in Vivo UBE2D3 Targets and Implicates UBE2D3 in Protein Quality Control

Molecular & Cellular Proteomics, 2023
Ubiquitination has crucial roles in many cellular processes, and dysregulation of ubiquitin machinery enzymes can result in various forms of pathogenesis. Cells only have a limited set of ubiquitin-conjugating (E2) enzymes to support the ubiquitination of many cellular targets.
Zeliha Yalçin, Daniëlle Koot, Karel Bezstarosti, Daniel Salas-Lloret, Onno B. Bleijerveld, Vera Boersma, Mattia Falcone, Román González-Prieto, Maarten Altelaar, Jeroen A.A. Demmers, Jacqueline J.L. Jacobs   +10 more
openaire   +7 more sources

Streptococcus pneumoniae and Influenza A Virus Co-Infection Induces Altered Polyubiquitination in A549 Cells

Frontiers in Cellular and Infection Microbiology, 2022
Epithelial cells are an important line of defense within the lung. Disruption of the epithelial barrier by pathogens enables the systemic dissemination of bacteria or viruses within the host leading to severe diseases with fatal outcomes.
Thomas Sura, Vanessa Gering, Clemens Cammann, Sven Hammerschmidt, Sandra Maaß, Ulrike Seifert, Dörte Becher   +6 more
doaj   +1 more source

ALS-linked loss of Cyclin-F function affects HSP90

Life Science Alliance, 2022
Analysis of ALS patient cell lines and cyclin-F overexpression and knockout cells identified HSP90AB1 as novel SCFcyclin-F substrate pointing to a loss-of-function mechanism for ALS CCNF mutations.
Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends   +3 more
doaj   +1 more source

Quantitative Ubiquitinomics Revealed Abnormal Ubiquitinated ATP7A Involved in Down-Regulation of ACTH in Silent Corticotroph Adenomas

Frontiers in Endocrinology, 2022
Ubiquitination is reported to be a critical biological event on ACTH secretion in corticotroph adenomas. However, the effect of ubiquitylation on ACTH secretion in silent corticotroph adenomas (SCAs) remains unclear. The aim of our study was to explore the mechanism of decreased secretion of ACTH in SCAs with ubiquitinomics.
Sida Zhao, Yue He, Hongyun Wang, Dan Li, Lei Gong, Yazhuo Zhang, Yazhuo Zhang, Chuzhong Li   +7 more
openaire   +3 more sources

G4‐Ligand‐Directed PROTACs Unveil DR1 as a Novel Ligand‐Co‐Binding G4‐Protein and Reshape G4‐Dependent Transcription

Advanced Science, Volume 13, Issue 27, 13 May 2026.
G4‐binding proteins (G4BPs) that specifically co‐bind G4s in the presence of small‐molecule ligands represent a critical but unexplored class of proteins. We introduce G4‐Ligand‐Directed PROTACs (G4L‐TACs), a chemical platform that couples G4 ligands (PDS) to E3 recruiters to selectively degrade these ligand‐co‐binding G4BPs.
Mao‐Lin Li, Shu‐Min Xu, Xin‐Chen Jiang, Le‐Tian Dai, Yu‐Tao Hu, Kai‐Bo Wang, Jia‐Heng Tan, Zhi‐Shu Huang, Shuo‐Bin Chen   +8 more
wiley   +1 more source

Ubiquitination-mediated molecular pathway alterations in human lung squamous cell carcinomas identified by quantitative ubiquitinomics

Frontiers in Endocrinology, 2022
Abnormal ubiquitination is extensively associated with cancers. To investigate human lung cancer ubiquitination and its potential functions, quantitative ubiquitinomics was carried out between human lung squamous cell carcinoma (LSCC) and control tissues, which characterized a total of 627 ubiquitin-modified proteins (UPs) and 1209 ubiquitinated lysine
Xianquan Zhan, Xianquan Zhan, Miaolong Lu, Miaolong Lu, Lamei Yang, Jingru Yang, Xiaohan Zhan, Xiaohan Zhan, Shu Zheng, Yuna Guo, Biao Li, Biao Li, Siqi Wen, Siqi Wen, Jiajia Li, Jiajia Li, Na Li, Na Li   +17 more
openaire   +3 more sources

The Analysis of the Ubiquitylomic Responses to Streptococcus agalactiae Infection in Bovine Mammary Gland Epithelial Cells

Journal of Inflammation Research, 2022
Jinjin Tong,1,* Xintong Ji,1,* Hua Zhang,1 Benhai Xiong,2 Defeng Cui,3 Linshu Jiang1 1Beijing Key Laboratory for Dairy Cow Nutrition, Beijing University of Agriculture, Beijing, People’s Republic of China; 2State Key Laboratory of Animal ...
Tong J, Ji X, Zhang H, Xiong B, Cui D, Jiang L   +5 more
doaj  

Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology [PDF]

, 2020
SUMMARY Protein ubiquitination is involved in virtually all cellular processes. Enrichment strategies employing antibodies targeting ubiquitin-derived diGly remnants combined with mass spectrometry (MS) have enabled investigations of ubiquitin signaling at a large scale.
Fynn M. Hansen, Maria C. Tanzer, Franziska Brüning, Isabell Bludau, Brenda A. Schulman, Maria S. Robles, Ozge Karayel, Matthias Mann   +7 more
openaire   +1 more source

Epigenetic regulation of mycorrhizal symbioses: from plastic responses to transgenerational legacies

New Phytologist, Volume 250, Issue 3, Page 1438-1452, May 2026.
Summary Mycorrhizal symbioses represent one of the most widespread and ecologically significant plant–microbe interactions, shaping plant nutrition, stress resilience, and ecosystem functioning. Beyond their role in nutrient exchange and systemic defense, growing evidence suggests that these symbioses also influence plant plasticity within and across ...
Gerson Beltrán‐Torres, Henry J. De La Cruz, Stéphane Maury, Martina Janoušková, Claire Veneault‐Fourrey, Vít Latzel, Pierre‐Emmanuel Courty, Harold Duruflé, Jörg Tost, Iris Sammarco   +9 more
wiley   +1 more source

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, Volume 13, Issue 19, 2 April 2026.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source