Results 51 to 60 of about 760 (147)

Raw dataset for Integrated phosphoproteome, ubiquitinome, and acetylome analyses uncovering the post-translational modifications crosstalk during MSP1-induced signaling in rice

, 2023
Supplementary files related to the data article "Proteome analysis dataset of Post-Translational Modifications in MSP1-overexpressed rice"G.H. Lee,C.W. Min, J.W. Jang, G. Ravi, S.T. Kim.
Kim, S (via Mendeley Data), Kim, Sun Tae
core   +1 more source

Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates [PDF]

, 2022
The ubiquitin-proteasome axis has been extensively explored at a system-wide level, but the impact of deubiquitinating enzymes (DUBs) on the ubiquitinome remains largely unknown. Here, we compare the contributions of the proteasome and DUBs on the global
Akimov, V., Vertegaal, Alfred C. O., Shah, R.G., Blagoev, B., Overbeek, N. van, Shah, Rashmi G., Shah, G., Akimov, Vyacheslav, Trulsson, Fredrik, Robu, M., Blagoev, Blagoy, van Overbeek, N., van Overbeek, Nila, Shah, Girish M., Cox, J., Vertegaal, Alfred C O, Vertegaal, A.C.O., Trulsson, F., Vertegaal, A., Blagoev, Blagoy; id_orcid, Shah, G.M., Berrocal, D., Berrocal, David Aureliano Pérez, Cox, Jürgen, Shah, R., Berrocal, D.A.P., Shah, Rashmi G, Robu, Mihaela, Shah, Girish M, Girish M. Shah, Mihaela Robu, Rashmi G. Shah, Vyacheslav Akimov, Fredrik Trulsson, Alfred C. O. Vertegaal, Blagoy Blagoev, Jürgen Cox, Nila van Overbeek, David Aureliano Pérez Berrocal   +38 more
core   +1 more source

The global proteome and ubiquitinome of bacterial and viral co-infected bronchial epithelial cells

Journal of Proteomics, 2022
Viral infections facilitate bacterial trafficking to the lower respiratory tract resulting in bacterial-viral co-infections. Bacterial dissemination to the lower respiratory tract is enhanced by influenza A virus induced epithelial cell damage and dysregulation of immune responses.
Thomas, Sura, Surabhi, Surabhi, Sandra, Maaß, Sven, Hammerschmidt, Nikolai, Siemens, Dörte, Becher   +5 more
openaire   +2 more sources

Site-Specific K63 Ubiquitinomics Provides Insights into Translation Regulation under Stress [PDF]

Journal of Proteome Research, 2018
During oxidative stress, K63-linked polyubiquitin chains modify a variety of proteins including ribosomes. Knowledge of the precise sites of K63 ubiquitin is key to understand its function during the response to stress. To identify the sites of K63 ubiquitin, we developed a new mass spectrometry based method that quantified >1100 K63 ubiquitination ...
Songhee Back, Andrew W. Gorman, Christine Vogel, Gustavo M. Silva   +3 more
openaire   +2 more sources

The mechano-ubiquitinome of articular cartilage: differential ubiquitination and activation of a group of ER-associated DUBs and ER stress regulators [PDF]

, 2022
Understanding how connective tissue cells respond to mechanical stimulation is important to human health and disease processes in musculoskeletal diseases.
Pinto-Fernández, A., Ismail, H.M., Kessler, Benedikt M., Kaokhum, N., Kessler, B.M., Ismail, Heba M., Kaokhum, Nitchakarn, Wilkinson, Mark, Wilkinson, M., Pinto-Fernández, Adán   +9 more
core   +1 more source

Serpinc1 Acts as a Tumor Suppressor in Hepatocellular Carcinoma Through Inducing Apoptosis and Blocking Macrophage Polarization in an Ubiquitin-Proteasome Manner

Frontiers in Oncology, 2021
Serpinc1 is a serine protease inhibitor in the coagulation cascade, but its role in tumor biology remains obscure. Here, we report an unexpected role of serpinc1 in suppression of hepatocellular carcinoma (HCC).
Dacai Xu, Dacai Xu, Jiawen Wu, Liang Dong, Wenwen Luo, Lanying Li, Daolin Tang, Jinbao Liu   +7 more
doaj   +1 more source

Streptococcus pneumoniae and Influenza A Virus Co-Infection Induces Altered Polyubiquitination in A549 Cells

Frontiers in Cellular and Infection Microbiology, 2022
Epithelial cells are an important line of defense within the lung. Disruption of the epithelial barrier by pathogens enables the systemic dissemination of bacteria or viruses within the host leading to severe diseases with fatal outcomes.
Thomas Sura, Vanessa Gering, Clemens Cammann, Sven Hammerschmidt, Sandra Maaß, Ulrike Seifert, Dörte Becher   +6 more
doaj   +1 more source

Improvement of ubiquitylation site detection by Orbitrap mass spectrometry [PDF]

, 2017
Ubiquitylation is an important posttranslational protein modification that is involved in many cellular events. Immunopurification of peptides containing a K-epsilon-diglycine (diGly) remnant as a mark of ubiquitylation combined with mass spectrometric ...
Rijkers, E, van der Wal, Lennart, Karel Bezstarosti, Mientjes, Edwin; id_orcid, Elgersma, Ype; id_orcid, Jeroen A.A. Demmers, Sap, Karen, Lennart van der Wal, Demmers, Jeroen, Edwin Mientjes, Dick H.W. Dekkers, Karen A. Sap, Erikjan Rijkers, Bezstarosti, Karel, Ype Elgersma, Dekkers, Dick, Rijkers, E.J., Mientjes, E.J. (Edwin), Dekkers, D.H. (Dick), Bezstarosti, K. (Karel), Sap, K.A. (Karen), van der Wal, L. (Lennart), Elgersma, Y. (Ype), Demmers, J.A.A. (Jeroen)   +23 more
core   +2 more sources

ALS-linked loss of Cyclin-F function affects HSP90

Life Science Alliance, 2022
Analysis of ALS patient cell lines and cyclin-F overexpression and knockout cells identified HSP90AB1 as novel SCFcyclin-F substrate pointing to a loss-of-function mechanism for ALS CCNF mutations.
Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends   +3 more
doaj   +1 more source

Ubiquitinome dynamics and regulation by DUB2 during Leishmania differentiation

Abstract Leishmaniasis is caused by Leishmania parasites, which undergo cellular adaptation when transitioning from the insect stage (promastigote) to the mammalian stage (amastigote). While the ubiquitin-proteasome system (UPS) is vital for life cycle progression, global ubiquitination dynamics have remained unmapped.
Antoniou S, Jones NG, Geoghegan V, Dowle A, McNiven C, Neish R, MacDonald C, Wilkinson AJ, Mottram JC.   +8 more
europepmc   +2 more sources