Results 61 to 70 of about 662 (121)

Hsp90 inhibition induces both protein-specific and global changes in the ubiquitinome

, 2015
Inhibition of the essential chaperone Hsp90 with drugs causes a global perturbation of protein folding and the depletion of direct substrates of Hsp90, also called clients.
Quadroni, M., Alexandra Potts, Potts, A., Manfredo Quadroni, Patrice Waridel, Waridel, P.   +5 more
core   +1 more source

Recent advances in proteomic workflows to interrogate the SUMOylome in plants

New Phytologist, Volume 247, Issue 1, Page 90-96, July 2025.
Summary Protein posttranslational modifications (PTMs) are vital for regulating protein functions. SUMOylation, a PTM essential for plant survival, involves attaching a Small Ubiquitin‐like MOdifier (SUMO) to lysine residues of target proteins. SUMOylation influences stress tolerance, cell proliferation, protein stability, and gene expression.
Kishor D. Ingole, Elizaveta Alekseeva, Kathryn S. Lilley, Ari Sadanandom   +3 more
wiley   +1 more source

Root ubiquitinome under osmotic stress

, 2021
International ...
Krouk, Gabriel, Berger, Nathalie, Rofidal, Valérie, Santoni, Veronique, Demolombe - Liozu, Vincent, Hem, Sonia, Steinmann, Laura, Verdoucq, Lionel   +7 more
core   +1 more source

Ubiquitin‐specific protease 25 improves myocardial ischemia–reperfusion injury by deubiquitinating NLRP3 and negatively regulating NLRP3 inflammasome activity in cardiomyocytes

Clinical and Translational Medicine, Volume 15, Issue 2, February 2025.
Abstract Background Myocardial ischemia/reperfusion injury (MI/RI) restricts the effect of myocardial reperfusion therapy and lacks effective prevention and treatment methods. Deubiquitinating enzymes (DUBs), especially members of the ubiquitin‐specific protease (USP) family of DUBs, are key proteins in the ubiquitination modification process and play
Bozhi Ye, Diyun Xu, Lingfeng Zhong, Yi Wang, Wei Wang, Haowen Xu, Xue Han, Julian Min, Gaojun Wu, Wenhai Huang, Guang Liang   +10 more
wiley   +1 more source

Characterization of the Ubiquitin‐Modified Proteome of Recombinant Chinese Hamster Ovary Cells in Response to Endoplasmic Reticulum Stress

Biotechnology Journal, Volume 19, Issue 11, November 2024.
Graphical Abstract and Lay Summary Ubiquitination is an essential cellular process in which proteins are tagged with ubiquitin, marking them for proteasomal degradation. Beyond this role, ubiquitination plays key functions in ER stress, cell signalling, autophagy, and cell cycle regulation. To gain deep insights into ER stress mechanisms and changes to
Karuppuchamy Selvaprakash, Christiana‐Kondylo Sideri, Michael Henry, Esen Efeoglu, David Ryan, Paula Meleady   +5 more
wiley   +1 more source

Ubiquitin signalling in Drosophila innate immune responses

The FEBS Journal, Volume 291, Issue 20, Page 4397-4413, October 2024.
Drosophila innate immunity against bacterial infection relies on humoral responses regulated by the Imd and Toll pathways activating NF‐κB transcription factors, as well as JNK activation and JAK/STAT signalling. These pathways are characterised by E3 ligases and deubiquitinating enzymes that determine ubiquitination of signalling molecules followed by
Anna L. Aalto, Veera Luukkonen, Annika Meinander   +2 more
wiley   +1 more source

Genetic variation in ZmKW1 contributes to kernel weight and size in dent corn and popcorn

Plant Biotechnology Journal, Volume 22, Issue 6, Page 1453-1467, June 2024.
Summary Kernel weight is a critical factor that essentially affects maize (Zea mays) yield. In natural inbred lines, popcorn kernels exhibit overtly smaller sizes compared to dent corn kernels, and kernel weight, which is controlled by multiple genetic loci, varies widely.
Long Zhang, Miaomiao Fu, Wenyu Li, Yongbin Dong, Qiang Zhou, Qilei Wang, Xinyu Li, Jie Gao, Yan Wang, Han Wang, Yayong Li, Jiechen Wang, Yongrui Wu, Yuling Li   +13 more
wiley   +1 more source

Deciphering non-canonical ubiquitin signaling: biology and methodology

Frontiers in Molecular Biosciences
Ubiquitination is a dynamic post-translational modification that regulates virtually all cellular processes by modulating function, localization, interactions and turnover of thousands of substrates.
Nila K. van Overbeek, Tim Aguirre, Gerbrand J. van der Heden van Noort, Blagoy Blagoev, Alfred C. O. Vertegaal   +4 more
doaj   +1 more source

The raw data of the SKIP14.A2-OE/CK transgenic hairy roots' ubiquitinome in rapeseeds

To system-wide identify the degradation substrates of SKIP14.A2, 35S::SKIP14.A2 transgenic ZS11 hairy roots were constructed, and the independently expressed mGFP (with the promoter of 2×35S) was used as a screening marker for positive transgenic ...
can liu (4453648)
core   +1 more source

How ubiquitination regulates the TGF-β signalling pathway: New insights and new players [PDF]

, 2011
Ubiquitination of protein species in regulating signal transduction pathways is universally accepted as of fundamental importance for normal development, and defects in this process have been implicated in the progression of many human diseases.
Soond, Surinder M., Chantry, Andrew, Andrew Chantry, Surinder M. Soond   +3 more
core   +1 more source