Results 81 to 90 of about 760 (147)

Structural proteomics of the human ubiquitinome

Abstract The proteasome maintains the integrity of eukaryotic proteomes by selectively degrading ubiquitinated protein substrates. Ubiquitination targets a wide range of substrates for degradation, including translationally stalled nascent chains, misfolded proteins, and properly folded but short-lived proteins destined for regulatory ...
Anushka Jain, Naiyareen Mayeen, Michael E. Meadow, Nino Kalandadze, Kyle Swovick, Kevin A. Welle, Jennifer R. Hryhorenko, Sina Ghaemmaghami   +7 more
openaire   +1 more source

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, Volume 13, Issue 19, 2 April 2026.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source

Comprehensive analysis of the ubiquitinome during oncogene-induced senescence in human fibroblasts

, 2016
Oncogene-induced senescence (OIS) is an important tumor suppression mechanism preventing uncontrolled proliferation in response to aberrant oncogenic signaling.
Hsin-Yao Tang (395357), Hengrui Zhu (704478), Zhigang Tu (704477), David W Speicher (9078760), Rugang Zhang (395360), Fee Bengsch (704476)   +5 more
core   +1 more source

Recent advances in proteomic workflows to interrogate the SUMOylome in plants

New Phytologist, Volume 247, Issue 1, Page 90-96, July 2025.
Summary Protein posttranslational modifications (PTMs) are vital for regulating protein functions. SUMOylation, a PTM essential for plant survival, involves attaching a Small Ubiquitin‐like MOdifier (SUMO) to lysine residues of target proteins. SUMOylation influences stress tolerance, cell proliferation, protein stability, and gene expression.
Kishor D. Ingole, Elizaveta Alekseeva, Kathryn S. Lilley, Ari Sadanandom   +3 more
wiley   +1 more source

Data-independent acquisition (DIA) approach for comprehensive ubiquitinome profiling in targeted protein degradation

Scientific Reports
Abstract Targeted protein degradation (TPD) has emerged as a highly promising therapeutic strategy for a wide range of diseases, including cancer and neurodegenerative disorders. The ubiquitin-proteasome system, which is responsible for protein degradation, plays a critical role in this process. Gaining comprehensive insights into the
Sathe G, Röth S, Gelders G, Brewer A, Macartney TJ, Wood NT, De Muynck L, Nakasone MA, Phung TK, Buist A, Moechars D, Sapkota GP.   +11 more
europepmc   +2 more sources

Ubiquitin‐specific protease 25 improves myocardial ischemia–reperfusion injury by deubiquitinating NLRP3 and negatively regulating NLRP3 inflammasome activity in cardiomyocytes

Clinical and Translational Medicine, Volume 15, Issue 2, February 2025.
Abstract Background Myocardial ischemia/reperfusion injury (MI/RI) restricts the effect of myocardial reperfusion therapy and lacks effective prevention and treatment methods. Deubiquitinating enzymes (DUBs), especially members of the ubiquitin‐specific protease (USP) family of DUBs, are key proteins in the ubiquitination modification process and play
Bozhi Ye, Diyun Xu, Lingfeng Zhong, Yi Wang, Wei Wang, Haowen Xu, Xue Han, Julian Min, Gaojun Wu, Wenhai Huang, Guang Liang   +10 more
wiley   +1 more source

Characterization of the Ubiquitin‐Modified Proteome of Recombinant Chinese Hamster Ovary Cells in Response to Endoplasmic Reticulum Stress

Biotechnology Journal, Volume 19, Issue 11, November 2024.
Graphical Abstract and Lay Summary Ubiquitination is an essential cellular process in which proteins are tagged with ubiquitin, marking them for proteasomal degradation. Beyond this role, ubiquitination plays key functions in ER stress, cell signalling, autophagy, and cell cycle regulation. To gain deep insights into ER stress mechanisms and changes to
Karuppuchamy Selvaprakash, Christiana‐Kondylo Sideri, Michael Henry, Esen Efeoglu, David Ryan, Paula Meleady   +5 more
wiley   +1 more source

How ubiquitination regulates the TGF-β signalling pathway: New insights and new players [PDF]

, 2011
Ubiquitination of protein species in regulating signal transduction pathways is universally accepted as of fundamental importance for normal development, and defects in this process have been implicated in the progression of many human diseases.
Soond, Surinder M., Chantry, Andrew, Andrew Chantry, Surinder M. Soond   +3 more
core   +1 more source

Ubiquitin signalling in Drosophila innate immune responses

The FEBS Journal, Volume 291, Issue 20, Page 4397-4413, October 2024.
Drosophila innate immunity against bacterial infection relies on humoral responses regulated by the Imd and Toll pathways activating NF‐κB transcription factors, as well as JNK activation and JAK/STAT signalling. These pathways are characterised by E3 ligases and deubiquitinating enzymes that determine ubiquitination of signalling molecules followed by
Anna L. Aalto, Veera Luukkonen, Annika Meinander   +2 more
wiley   +1 more source

The raw data of the SKIP14.A2-OE/CK transgenic hairy roots' ubiquitinome in rapeseeds

To system-wide identify the degradation substrates of SKIP14.A2, 35S::SKIP14.A2 transgenic ZS11 hairy roots were constructed, and the independently expressed mGFP (with the promoter of 2×35S) was used as a screening marker for positive transgenic ...
can liu (4453648)
core   +1 more source