Results 91 to 100 of about 760 (147)

Deciphering non-canonical ubiquitin signaling: biology and methodology

Frontiers in Molecular Biosciences
Ubiquitination is a dynamic post-translational modification that regulates virtually all cellular processes by modulating function, localization, interactions and turnover of thousands of substrates.
Nila K. van Overbeek, Tim Aguirre, Gerbrand J. van der Heden van Noort, Blagoy Blagoev, Alfred C. O. Vertegaal   +4 more
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Multilayered proteomics reveals molecular switches dictating ligand-dependent EGFR trafficking [PDF]

, 2016
A fascinating conundrum in cell signaling is how stimulation of the same receptor tyrosine kinase with distinct ligands generates specific outcomes. To decipher the functional selectivity of EGF and TGF-α, which induce epidermal growth factor receptor ...
Olsen, Jesper V, Francavilla, Chiara; id_orcid, Papetti, Moreno, Anna-Kathrine Pedersen, Blagoev, Blagoy; id_orcid, Pedersen, Anna-Kathrine, Blagoy Blagoev, Giuseppe Cazzamali, Sigurdsson, Jon O, Francavilla, Chiara, Jon O Sigurdsson, Rigbolt, Kristoffer T G, Cazzamali, Giuseppe, Gopal Karemore, Chiara Francavilla, Karemore, Gopal, Blagoev, Blagoy, Olsen, Jesper Velgaard, Kristoffer T G Rigbolt, Moreno Papetti, Jesper V Olsen   +20 more
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Unraveling the Complex Web of Mechanistic Regulation of Versatile NEDD4 Family by Non-Coding RNAs in Carcinogenesis and Metastasis: From Cell Culture Studies to Animal Models

, 2023
Discoveries related to an intriguing feature of ubiquitination have prompted a detailed analysis of the ubiquitination patterns in malignant cells. How the “ubiquitinome” is reshaped during multistage carcinogenesis has garnered significant ...
Venera Rakhmetova, Almat Kodasbayev, Gulmira Makhanbetovna Datkayeva, Abay M. Shepetov, Sabit B. Pazilov, Ubaidilla M. Datkhayev, Ammad Ahmad Farooqi   +6 more
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Comparative ubiquitinomics of human skin reveals insulin receptor ubiquitination as a regulator of collagen secretion

Communications Biology
Abstract Ubiquitination is central to skin homeostasis and disease, however the cutaneous ubiquitinome remains poorly characterised. We investigated spatial patterns of ubiquitination in human skin, discovering specific ubiquitin linkages located within the hair follicle and epidermis.
Joseph Inns, Andrew Michael Frey, Ishier Raote, Mads Gyrd-Hansen, Matthias Trost, Neil Rajan   +5 more
openaire   +2 more sources

Integrative Proteome and Ubiquitinome Analyses Reveal the Substrates of BTBD9 and Its Underlying Mechanism in Sleep Regulation

Ubiquitination is a major posttranslational modification of proteins that affects their stability, and E3 ligases play a key role in ubiquitination by specifically recognizing their substrates.
Jian Guan (288307), Shankai Yin (142622), Zhenfei Gao (4058959), Anzhao Wang (11893505), Niannian Li (123776), Feng Liu (72874), Xiaoxu Zhang (1422019), Chong Xu (536395), Shenming Wang (181422), Yongxu Zhao (12327822), Xiangshan Yuan (11280261), Yaxin Zhu (152721), Jingyu Zhu (8895188)   +12 more
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Root membrane ubiquitinome study identifies E2 Ub conjugating enzymes UBC32 and UBC34 that contribute to primary root growth under osmotic stress

, 2022
International audienceOsmotic stress can be detrimental to plants whose survival relies heavily on proteomic plasticity. Protein ubiquitination is a central post-translational modification in abiotic mediated stresses (Stone 2018).
Krouk, Gabriel, Berger, Nathalie, Nacry, Philippe, Crabos, Amandine, Rofidal, Valérie, Demolombe - Liozu, Vincent, Santoni-Kervella, Véronique, Hem, Sonia, Steinmann, Laura, Verdoucq, Lionel   +9 more
core  

La digestió de proteïnes es fa gran per ajudar en l'estudi de l'ubiquitinoma

, 2017
El Laboratori de Proteòmica CSIC/UAB ha desenvolupat un mètode de digestió de proteïnes a gran escala (LFASP) i demostrat la utilitat d'aquest mètode per a l'estudi de l'ubiquitinoma.
Casanovas, Albert, Abian, Joaquin
core   +1 more source

Identification of OTUD7a downregulation and global ubiquitination remodeling in a murine asthma model

Experimental and Molecular Pathology
Airway epithelial dysfunction is a hallmark of asthma, contributing to chronic inflammation and structural remodeling. Recent research suggests the role of post-translational modifications in regulating epithelial immune responses.
Yanbo Liu, Xuanyuan Pan, Haoyue Zhang, Ying Zhou, Juan Zhi, Jin Xu, Qianyu Wang, Quanle Liu, Kaixuan Zhao, Weipeng Xia, Haotian Chen, Dong Yang   +11 more
doaj   +1 more source

It's time for some 'site'-seeing: novel tools to monitor the ubiquitin landscape in Arabidopsis thaliana

, 2016
Ubiquitination, the covalent binding of the small protein modifier ubiquitin to a target protein, is an important and frequently studied posttranslational protein modification.
Van Bel, Michiel, Coppens, Frederik, Goormachtig, Sofie, Nagels Durand, Astrid, Pauwels, Laurens, Walton, Alan, De Smet, Ive, De Veylder, Lieven, Cybulski, Nicolas, Stes, Elisabeth, Timmerman, Evy, Heyman, Jefri, Gevaert, Kris, Goossens, Alain, Iñigo, Sabrina   +14 more
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Ubiquitinomics [PDF]

Nature Cell Biology, 2011
openaire   +1 more source