Proteogenomic reprogramming to a functional human blastomere-like stem cell state via a PARP-DUX4 regulatory axis [PDF]
Cell ReportsSummary: Here, we show that conventional human pluripotent stem cells cultured with non-specific tankyrase-PARP1-inhibited conditions underwent proteogenomic reprogramming to functional blastomere-like tankyrase/PARP inhibitor-regulated naive stem cells (
Ludovic Zimmerlin +11 more
doaj +2 more sources
Ubiquitinome Profiling Reveals in Vivo UBE2D3 Targets and Implicates UBE2D3 in Protein Quality Control [PDF]
, 2023 Ubiquitination has crucial roles in many cellular processes, and dysregulation of ubiquitin machinery enzymes can result in various forms of pathogenesis.
Demmers, Jeroen A.A. +10 more
core +3 more sources
System-wide identification of novel de-ubiquitination targets for USP10 in gastric cancer metastasis through multi-omics screening [PDF]
BMC CancerObjective Ubiquitin-specific peptidase 10 (USP10), a typical de-ubiquitinase, has been found to play a double-edged role in human cancers. Previously, we reported that the expression of USP10 was negatively correlated with the depth of gastric wall ...
Zhi Zeng +12 more
doaj +2 more sources
Dynamic changes to the skeletal muscle proteome and ubiquitinome induced by the E3 ligase, ASB2β [PDF]
, 2021 Ubiquitination is a posttranslational protein modification that has been shown to have a range of effects, including regulation of protein function, interaction, localization, and degradation.
Gregorevic, Paul +9 more
core +1 more source
Global Analysis of Host and Bacterial Ubiquitinome in Response to Salmonella Typhimurium Infection
, 2022 S.967-981Ubiquitination serves as a critical signal in the host immune response to infection. Many pathogens have evolved strategies to exploit the ubiquitin (Ub) system to promote their own survival through a complex interplay between host defense ...
Bionda, T. +3 more
core +1 more source
Ubiquitin proteomics identifies RNA polymerase I as a target of the Smc5/6 complex
Cell Reports, 2023 Summary: Ubiquitination controls numerous cellular processes, and its deregulation is associated with many pathologies. The Nse1 subunit in the Smc5/6 complex contains a RING domain with ubiquitin E3 ligase activity and essential functions in genome ...
Eva Ibars +10 more
doaj +1 more source
Engineering, 2020 Primary hepatocytes (PHCs) are widely used in various fields, but the progressive deterioration of liver-specific features in vitro significantly limits their application.
Zhengyi Jiang +9 more
doaj +1 more source
Mass Spectrometry Reviews, Volume 42, Issue 6, Page 2324-2348, November/December 2023., 2023 Abstract The data‐independent acquisition mass spectrometry (DIA‐MS) has rapidly evolved as a powerful alternative for highly reproducible proteome profiling with a unique strength of generating permanent digital maps for retrospective analysis of biological systems.
Reta Birhanu Kitata +2 more
wiley +1 more source
MedComm, Volume 4, Issue 3, June 2023., 2023 The reversible and irreversible protein posttranslational modifications, such as acetylation, methylation, phosphorylation, ubiquitination, glycosylation, SUMOylation, and redox modifications, are essential regulators in organisms and cells. This work systematically summarizes the features, regulatory mechanisms, substrates, functions, and related ...
Qian Zhong +10 more
wiley +1 more source
The mechano-ubiquitinome of articular cartilage: differential ubiquitination and activation of a group of ER-associated DUBs and ER stress regulators [PDF]
, 2022 Understanding how connective tissue cells respond to mechanical stimulation is important to human health and disease processes in musculoskeletal diseases.
Pinto-Fernández, A. +11 more
core +1 more source