Ubiquitinome Profiling Reveals the Landscape of Ubiquitination Regulation in Rice Young Panicles
Genomics, Proteomics and Bioinformatics, 2020 Ubiquitination, an essential post-transcriptional modification (PTM), plays a vital role in nearly every biological process, including development and growth.
Erdong Ni +2 more
exaly +5 more sources
Insights into the protein ubiquitinome in the host‒pathogen interplay during Mycobacterium tuberculosis infection [PDF]
Frontiers in Molecular BiosciencesMycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis capable of manipulating and circumventing the host’s immune system to establish infection.
Qishun Feng +6 more
doaj +5 more sources
Insights into ubiquitinome dynamics in the host‒pathogen interplay during Francisella novicida infection [PDF]
Cell Communication and SignalingUbiquitination functions as an important posttranslational modification for orchestrating inflammatory immune responses and cell death during pathogenic infection.
Luyu Yang +4 more
doaj +4 more sources
Global ubiquitinome analysis reveals the role of E3 ubiquitin ligase FaBRIZ in strawberry fruit ripening [PDF]
Journal of Experimental Botany, 2023 AbstractUbiquitination is an important post-translational modification that mediates protein degradation in eukaryotic cells, participating in multiple biological processes. However, the profiling of protein ubiquitination and the function of this crucial modification in fruit ripening remain largely unknown. In this study, we found that suppression of
Guozheng Qin +2 more
exaly +4 more sources
A targeted multi-proteomics approach generates a blueprint of the ciliary ubiquitinome
Frontiers in Cell and Developmental Biology, 2023 Establishment and maintenance of the primary cilium as a signaling-competent organelle requires a high degree of fine tuning, which is at least in part achieved by a variety of post-translational modifications.
Mariam G. Aslanyan +14 more
doaj +8 more sources
Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology [PDF]
Nature Communications, 2021 Protein ubiquitylation is often studied by proteomics but how data independent acquisition (DIA) may advance these studies remains to be explored. Here, the authors show that DIA improves ubiquitylation site identification and quantification, enabling ...
Fynn M. Hansen +8 more
doaj +4 more sources
Ubiquitinomics: History, methods, and applications in basic research and drug discovery
PROTEOMICS, Volume 22, Issue 15-16, August 2022., 2022 Abstract The ubiquitin‐proteasome system (UPS) was discovered about 40 years ago and is known to regulate a multitude of cellular processes including protein homeostasis. Ubiquitylated proteins are recognized by downstream effectors, resulting in alterations of protein abundance, activity, or localization. Not surprisingly, the ubiquitylation machinery
Martin Steger +2 more
wiley +4 more sources
Time-resolved in vivo ubiquitinome profiling by DIA-MS reveals USP7 targets on a proteome-wide scale
Nature Communications, 2021 Combining improved sample preparation, data-independent acquisition mass spectrometry and deep learning, the authors develop a workflow for more robust and precise quantitative ubiquitinome profiling.
Markus Ralser +2 more
exaly +2 more sources
Dataset on post-translational modifications proteome analysis of MSP1-overexpressing rice leaf proteins [PDF]
Data in Brief, 2023 The data reported here are associated with the article entitled “Analysis of Post-Translational Modification Dynamics Unveiled Novel Insights into Rice Responses to MSP1” [1].
Gi Hyun Lee +4 more
doaj +2 more sources
Integrative Omics Reveals Glutamine Catabolism-Driven Apoptotic Suppression in Monocytes upon Mechanical Unloading. [PDF]
Adv Sci (Weinh)This research integrated multi‐omics analysis of bone tissue from HLU and control mice revealed that mechanical unloading suppresses intrinsic apoptosis and augments glutamine (Gln) catabolism in osteoclast lineage cells. The findings highlight pivotal roles for SLC1A5‐mediated Gln metabolism and XIAP/Diablo axis‐mediated apoptosis suppression.
Ding Y +14 more
europepmc +2 more sources