Light‐Activatable Ubiquitin for Studying Linkage‐Specific Ubiquitin Chain Formation Kinetics [PDF]
Advanced ScienceUbiquitination is a dynamic post‐translational modification governing protein abundance, function, and localization in eukaryotes. The Ubiquitin protein is conjugated to lysine residues of target proteins, but can also repeatedly be ubiquitinated itself,
Sudakshina Banerjee +7 more
doaj +6 more sources
A multilevel investigation to reveal the regulatory mechanism of lignin accumulation in juice sac granulation of pomelo [PDF]
BMC Plant BiologyGranulation of juice sacs is a physiological disorder, which affects pomelo fruit quality. Here, the transcriptome and ubiquitinome of the granulated juice sacs were analyzed in Guanxi pomelo.
Luning Liu +10 more
doaj +3 more sources
FOXM1 Protects Against Myocardial Ischemia‐Reperfusion Injury in Rodent and Porcine Models by Suppressing MKRN1‐Dependent LKB1 Ubiquitination [PDF]
Advanced ScienceMitochondrial dysfunction is related to etiopathogenesis and progression of heart failure (HF). The underlying molecular mechanisms are not fully understood. Transcription factor FOXM1 plays an essential role in cardiovascular development.
Shuai Song +17 more
doaj +3 more sources
Dataset on post-translational modifications proteome analysis of MSP1-overexpressing rice leaf proteins [PDF]
Data in Brief, 2023 The data reported here are associated with the article entitled “Analysis of Post-Translational Modification Dynamics Unveiled Novel Insights into Rice Responses to MSP1” [1].
Gi Hyun Lee +4 more
doaj +3 more sources
The Lolal-dpp axis mediates the regulation of host reproduction by gut symbionts in insects [PDF]
Nature CommunicationsGut commensal microbiota can play an integral role in shaping insect reproduction, but the underlying mechanisms remain largely unexplored. Here, we report that gut bacteria promote host reproduction in the oriental fruit fly Bactrocera dorsalis by ...
Jiao Qiao +6 more
doaj +3 more sources
The Proteasomal Deubiquitinating Enzyme PSMD14 Regulates Macroautophagy by Controlling Golgi-to-ER Retrograde Transport [PDF]
Cells, 2020 Ubiquitination regulates several biological processes, however the role of specific members of the ubiquitinome on intracellular membrane trafficking is not yet fully understood.
Hianara A Bustamante +16 more
doaj +3 more sources
BOULE is Essential for the Dynamic Disassembly of Heat Shock Granules in Male Germ Cells. [PDF]
Adv Sci (Weinh)BOULE orchestrates stress granule disassembly in germ cells via a two‐pronged mechanism: it promotes G3BP1 ubiquitination by upregulating TRIM27, generating a signal for VCP/FAF2 recruitment, and it maintains G3BP1 and FAF2 protein levels. BOULE deficiency disrupts disassembly complex formation, leading to impaired heat shock granule clearance ...
Li X +8 more
europepmc +2 more sources
Integrative Omics Reveals Glutamine Catabolism-Driven Apoptotic Suppression in Monocytes upon Mechanical Unloading. [PDF]
Adv Sci (Weinh)This research integrated multi‐omics analysis of bone tissue from HLU and control mice revealed that mechanical unloading suppresses intrinsic apoptosis and augments glutamine (Gln) catabolism in osteoclast lineage cells. The findings highlight pivotal roles for SLC1A5‐mediated Gln metabolism and XIAP/Diablo axis‐mediated apoptosis suppression.
Ding Y +14 more
europepmc +2 more sources
Spatial Mechano‐Signaling Regulation of GTPases through Non‐Degradative Ubiquitination
Advanced Science, 2023 Blood flow produces shear stress exerted on the endothelial layer of the vessels. Spatial characterization of the endothelial proteome is required to uncover the mechanisms of endothelial activation by shear stress, as blood flow varies in the ...
Raj N. Sewduth +10 more
doaj +2 more sources
Tomato ubiquitinome in response to ‘Candidatus Liberibacter solanacearum’ haplotypes A and B [PDF]
Crop Health‘Candidatus Liberibacter solanacearum’ (Lso) is a devastating bacterial pathogen of crops transmitted by psyllids. Previously, a link between changes in ubiquitination and the progression of diseases caused by Lso was established.
Julien G. Levy +4 more
doaj +2 more sources