Results 11 to 20 of about 540 (119)

FOXM1 Protects Against Myocardial Ischemia‐Reperfusion Injury in Rodent and Porcine Models by Suppressing MKRN1‐Dependent LKB1 Ubiquitination [PDF]

Advanced Science
Mitochondrial dysfunction is related to etiopathogenesis and progression of heart failure (HF). The underlying molecular mechanisms are not fully understood. Transcription factor FOXM1 plays an essential role in cardiovascular development.
Shuai Song, Xiaokai Zhang, Zihang Huang, Zhiqiang Pei, Linqi Zeng, Fengze Cai, Tongyao Wang, Mohan Li, Chenyan Liu, Yining Song, Jiahao Guo, Hao Lu, Xinyu Weng, Li Shen, Xiaochun Zhang, Xingxing Cai, Aijun Sun, Junbo Ge   +17 more
doaj   +3 more sources

Time-resolved in vivo ubiquitinome profiling by DIA-MS reveals USP7 targets on a proteome-wide scale [PDF]

Nature Communications, 2021
Combining improved sample preparation, data-independent acquisition mass spectrometry and deep learning, the authors develop a workflow for more robust and precise quantitative ubiquitinome profiling.
Martin Steger, Vadim Demichev, Uli Ohmayer   +2 more
exaly   +4 more sources

Global ubiquitinome analysis reveals the role of E3 ubiquitin ligase FaBRIZ in strawberry fruit ripening [PDF]

Journal of Experimental Botany, 2023
AbstractUbiquitination is an important post-translational modification that mediates protein degradation in eukaryotic cells, participating in multiple biological processes. However, the profiling of protein ubiquitination and the function of this crucial modification in fruit ripening remain largely unknown. In this study, we found that suppression of
Weihao Wang, Guozheng Qin, Wang Weihao   +2 more
exaly   +4 more sources

A targeted multi-proteomics approach generates a blueprint of the ciliary ubiquitinome

Frontiers in Cell and Developmental Biology, 2023
Establishment and maintenance of the primary cilium as a signaling-competent organelle requires a high degree of fine tuning, which is at least in part achieved by a variety of post-translational modifications.
Mariam G. Aslanyan, Cenna Doornbos, Gaurav D. Diwan, Gaurav D. Diwan, Zeinab Anvarian, Tina Beyer, Katrin Junger, Sylvia E. C. van Beersum, Robert B. Russell, Robert B. Russell, Marius Ueffing, Alexander Ludwig, Karsten Boldt, Lotte B. Pedersen, Ronald Roepman   +14 more
doaj   +8 more sources

Ubiquitinomics: History, methods, and applications in basic research and drug discovery

PROTEOMICS, Volume 22, Issue 15-16, August 2022., 2022
Abstract The ubiquitin‐proteasome system (UPS) was discovered about 40 years ago and is known to regulate a multitude of cellular processes including protein homeostasis. Ubiquitylated proteins are recognized by downstream effectors, resulting in alterations of protein abundance, activity, or localization. Not surprisingly, the ubiquitylation machinery
Martin Steger, Özge Karayel, Vadim Demichev   +2 more
wiley   +4 more sources

Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology [PDF]

Nature Communications, 2021
Protein ubiquitylation is often studied by proteomics but how data independent acquisition (DIA) may advance these studies remains to be explored. Here, the authors show that DIA improves ubiquitylation site identification and quantification, enabling ...
Fynn M. Hansen, Maria C. Tanzer, Franziska Brüning, Isabell Bludau, Che Stafford, Brenda A. Schulman, Maria S. Robles, Ozge Karayel, Matthias Mann   +8 more
doaj   +4 more sources

Tomato ubiquitinome in response to ‘Candidatus Liberibacter solanacearum’ haplotypes A and B [PDF]

Crop Health
‘Candidatus Liberibacter solanacearum’ (Lso) is a devastating bacterial pathogen of crops transmitted by psyllids. Previously, a link between changes in ubiquitination and the progression of diseases caused by Lso was established.
Julien G. Levy, Jiaxing Liu, Junepyo Oh, Azucena Mendoza Herrera, Cecilia Tamborindeguy   +4 more
doaj   +2 more sources

Integrative proteomics reveals the role of E3 ubiquitin ligase SYVN1 in hepatocellular carcinoma metastasis

Cancer Communications, 2021
Background Tumor metastasis is a major factor for poor prognosis of hepatocellular carcinoma (HCC), but the relationship between ubiquitination and metastasis need to be studied more systematically.
Feiyang Ji, Menghao Zhou, Zeyu Sun, Zhengyi Jiang, Huihui Zhu, Zhongyang Xie, Xiaoxi Ouyang, Lingjian Zhang, Lanjuan Li   +8 more
doaj   +2 more sources

Dataset on post-translational modifications proteome analysis of MSP1-overexpressing rice leaf proteins [PDF]

Data in Brief, 2023
The data reported here are associated with the article entitled “Analysis of Post-Translational Modification Dynamics Unveiled Novel Insights into Rice Responses to MSP1” [1].
Gi Hyun Lee, Cheol Woo Min, Jeong Woo Jang, Ravi Gupta, Sun Tae Kim   +4 more
doaj   +2 more sources

Deciphering non-canonical ubiquitin signaling: biology and methodology [PDF]

Frontiers in Molecular Biosciences, 2023
Ubiquitination is a dynamic post-translational modification that regulates virtually all cellular processes by modulating function, localization, interactions and turnover of thousands of substrates.
Nila K. van Overbeek, Tim Aguirre, Gerbrand J. van der Heden van Noort, Blagoy Blagoev, Alfred C. O. Vertegaal   +4 more
doaj   +2 more sources