Results 21 to 30 of about 540 (119)

Spatial Mechano‐Signaling Regulation of GTPases through Non‐Degradative Ubiquitination

Advanced Science, 2023
Blood flow produces shear stress exerted on the endothelial layer of the vessels. Spatial characterization of the endothelial proteome is required to uncover the mechanisms of endothelial activation by shear stress, as blood flow varies in the ...
Raj N. Sewduth, Paolo Carai, Tonci Ivanisevic, Mingzhen Zhang, Hyunbum Jang, Benoit Lechat, Delphi Van Haver, Francis Impens, Ruth Nussinov, Elizabeth Jones, Anna Sablina   +10 more
doaj   +2 more sources

A multilevel investigation to reveal the regulatory mechanism of lignin accumulation in juice sac granulation of pomelo [PDF]

BMC Plant Biology
Granulation of juice sacs is a physiological disorder, which affects pomelo fruit quality. Here, the transcriptome and ubiquitinome of the granulated juice sacs were analyzed in Guanxi pomelo.
Luning Liu, Yiran Chen, Weilin Wu, Qiuyou Chen, Zhijiao Tian, Jiakang Huang, Huaqing Ren, Jiacheng Zhang, Xi Du, Mulai Zhuang, Ping Wang   +10 more
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Proteomic and ubiquitinome analysis reveal that microgravity affects glucose metabolism of mouse hearts by remodeling non-degradative ubiquitination [PDF]

PLoS ONE
Long-term exposure to a microgravity environment leads to structural and functional changes in hearts of astronauts. Although several studies have reported mechanisms of cardiac damage under microgravity conditions, comprehensive research on changes at ...
Xin Zhang, Xuemei Zhou, Zhiwei Tu, Lihua Qiang, Zhe Lu, Yuping Xie, Cui Hua Liu, Lingqiang Zhang, Yesheng Fu   +8 more
doaj   +3 more sources

VCPIP1 drives diabetic cardiomyopathy by deubiquitinating AMPKγ1 and preventing AMPKα-γ subunit assembly in cardiomyocytes [PDF]

Signal Transduction and Targeted Therapy
Protein ubiquitination modifications contribute to cardiomyocyte homeostasis and pathophysiology in diabetic cardiomyopathy (DCM). Yet the roles of deubiquitinating enzymes (DUBs) in DCM remain poorly defined.
Xue Han, Zhuqi Huang, Guoxuan Liu, Yanan Liu, Weiqi Li, Jianing Zheng, Jie Tong, Mingyang He, Yurou Wu, Ze Li, Wu Luo, Qiaojuan Shi, Huazhong Ying, Guang Liang   +13 more
doaj   +2 more sources

Aspirin inhibits proteasomal degradation and promotes α-synuclein aggregate clearance through K63 ubiquitination [PDF]

Nature Communications
Aspirin is a potent lysine acetylation inducer, but its impact on lysine ubiquitination and ubiquitination-directed protein degradation is unclear. Herein, we develop the reversed-pulsed-SILAC strategy to systematically profile protein degradome in ...
Jing Gao, Yang Liu, Chenfang Si, Rui Guo, Shouqiao Hou, Xiaosong Liu, Houfang Long, Di Liu, Daichao Xu, Zai-Rong Zhang, Cong Liu, Bing Shan, Christoph W. Turck, Kaiwen He, Yaoyang Zhang   +14 more
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Combined multiomics analysis reveals the mechanism of CENPF overexpression-mediated immune dysfunction in diffuse large B-cell lymphoma in vitro [PDF]

Frontiers in Genetics, 2022
Diffuse large B-cell lymphoma (DLBCL) is one of the most common aggressive B-cell lymphomas with significant heterogeneity. More than half of patients are cured, but 40%–45% still face relapse or develop drug resistance, and the mechanism is not yet ...
Dan Yang, Jia Wang, Mingqiu Hu, Feng Li, Feifei Yang, Youcai Zhao, Yanli Xu, Xuezhong Zhang, Lijun Tang, Xiuqun Zhang   +9 more
doaj   +2 more sources

A computational tool to infer enzyme activity using post-translational modification profiling data [PDF]

Communications Biology
Enzymes play a pivotal role in orchestrating complex cellular responses to external stimuli and environmental changes through signal transduction pathways.
Dehui Kong, Aijun Zhang, Ling Li, Zuo-Fei Yuan, Yingxue Fu, Long Wu, Ashutosh Mishra, Anthony A. High, Junmin Peng, Xusheng Wang   +9 more
doaj   +2 more sources

USP5 Promotes Ripretinib Resistance in Gastrointestinal Stromal Tumors by MDH2 Deubiquition

Advanced Science
Ripretinib, a broad‐spectrum inhibitor of the KIT and PDGFRA receptor tyrosine kinases, is designated as a fourth‐line treatment for gastrointestinal stromal tumor (GIST). It is tailored for patients resistant to imatinib, sunitinib, and regorafenib.
Haoyu Sun, Zhiwei Cui, Chao Li, Zhishuang Gao, Jun Xu, Yibo Bian, Tianhao Gu, Jianan Zhang, Tengyun Li, Qianzheng Zhou, Dinghua Yang, Zhongyuan He, Bowen Li, Fengyuan Li, Zekuan Xu, Hao Xu   +15 more
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The Lolal-dpp axis mediates the regulation of host reproduction by gut symbionts in insects [PDF]

Nature Communications
Gut commensal microbiota can play an integral role in shaping insect reproduction, but the underlying mechanisms remain largely unexplored. Here, we report that gut bacteria promote host reproduction in the oriental fruit fly Bactrocera dorsalis by ...
Jiao Qiao, Ziniu Li, Weiwei Zheng, Qiuyuan Zhang, Chenjun Zheng, Xiaoxue Li, Hongyu Zhang   +6 more
doaj   +2 more sources

Proteogenomic reprogramming to a functional human blastomere-like stem cell state via a PARP-DUX4 regulatory axis [PDF]

Cell Reports
Summary: Here, we show that conventional human pluripotent stem cells cultured with non-specific tankyrase-PARP1-inhibited conditions underwent proteogenomic reprogramming to functional blastomere-like tankyrase/PARP inhibitor-regulated naive stem cells (
Ludovic Zimmerlin, Ariana Angarita, Tea Soon Park, Rebecca Evans-Moses, Justin Thomas, Sirui Yan, Isabel Uribe, Isabella Vegas, Clara Kochendoerfer, Willem Buys, Anthony K.L. Leung, Elias T. Zambidis   +11 more
doaj   +2 more sources