Results 21 to 30 of about 760 (147)
The Lolal-dpp axis mediates the regulation of host reproduction by gut symbionts in insects [PDF]
Nature CommunicationsGut commensal microbiota can play an integral role in shaping insect reproduction, but the underlying mechanisms remain largely unexplored. Here, we report that gut bacteria promote host reproduction in the oriental fruit fly Bactrocera dorsalis by ...
Jiao Qiao +6 more
doaj +3 more sources
Ubiquitinome Profiling Reveals in Vivo UBE2D3 Targets and Implicates UBE2D3 in Protein Quality Control [PDF]
Molecular & Cellular Proteomics, 2023 Ubiquitination has crucial roles in many cellular processes, and dysregulation of ubiquitin machinery enzymes can result in various forms of pathogenesis. Cells only have a limited set of ubiquitin-conjugating (E2) enzymes to support the ubiquitination of many cellular targets.
Zeliha Yalçin +10 more
core +9 more sources
The Proteasomal Deubiquitinating Enzyme PSMD14 Regulates Macroautophagy by Controlling Golgi-to-ER Retrograde Transport [PDF]
Cells, 2020 Ubiquitination regulates several biological processes, however the role of specific members of the ubiquitinome on intracellular membrane trafficking is not yet fully understood.
Hianara A Bustamante +16 more
doaj +3 more sources
Journal of Experimental Botany, 2022 AbstractUbiquitination is an important post-translational modification that mediates protein degradation in eukaryotic cells, participating in multiple biological processes. However, the profiling of protein ubiquitination and the function of this crucial modification in fruit ripening remain largely unknown. In this study, we found that suppression of
Yuying Wang +3 more
openaire +3 more sources
Large-Scale Filter-Aided Sample Preparation Method for the Analysis of the Ubiquitinome
Analytical Chemistry, 2017 Protein ubiquitination regulates key cellular functions, including protein homeostasis and signal transduction. The digestion of ubiquitinated proteins with trypsin yields a glycine-glycine remnant bound to the modified lysine residue (K-ε-GG) that can be recognized by specific antibodies for immunoaffinity purification (IAP) and subsequent ...
Albert Casanovas +3 more
openaire +3 more sources
Cancer Communications, 2021 Background Tumor metastasis is a major factor for poor prognosis of hepatocellular carcinoma (HCC), but the relationship between ubiquitination and metastasis need to be studied more systematically.
Feiyang Ji +8 more
doaj +2 more sources
Hsp90 inhibition induces both protein-specific and global changes in the ubiquitinome
Journal of Proteomics, 2015 Inhibition of the essential chaperone Hsp90 with drugs causes a global perturbation of protein folding and the depletion of direct substrates of Hsp90, also called clients. Ubiquitination and proteasomal degradation play a key role in cellular stress responses, but the impact of Hsp90 inhibition on the ubiquitinome has not been characterized on a ...
Quadroni, M., Potts, A., Waridel, P.
openaire +5 more sources
Data in Brief, 2023 The data reported here are associated with the article entitled “Analysis of Post-Translational Modification Dynamics Unveiled Novel Insights into Rice Responses to MSP1” [1].
Gi Hyun Lee +4 more
doaj +2 more sources
Proteomic and ubiquitinome analysis reveal that microgravity affects glucose metabolism of mouse hearts by remodeling non-degradative ubiquitination [PDF]
PLoS ONELong-term exposure to a microgravity environment leads to structural and functional changes in hearts of astronauts. Although several studies have reported mechanisms of cardiac damage under microgravity conditions, comprehensive research on changes at ...
Xin Zhang +8 more
doaj +3 more sources
VCPIP1 drives diabetic cardiomyopathy by deubiquitinating AMPKγ1 and preventing AMPKα-γ subunit assembly in cardiomyocytes [PDF]
Signal Transduction and Targeted TherapyProtein ubiquitination modifications contribute to cardiomyocyte homeostasis and pathophysiology in diabetic cardiomyopathy (DCM). Yet the roles of deubiquitinating enzymes (DUBs) in DCM remain poorly defined.
Xue Han +13 more
doaj +2 more sources