Results 21 to 30 of about 662 (121)

Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodelling in neural crest cells [PDF]

Nature Communications, 2022
Here the authors combine multi-omics approaches to uncover a role for ubiquitination and the ubiquitin ligase NEDD4 in targeting the actin binding protein Profilin 1 to regulate actin polymerisation in neural crest cells.
Iman Lohraseb, Peter McCarthy, Genevieve Secker, Ceilidh Marchant, Jianmin Wu, Naveid Ali, Sharad Kumar, Roger J. Daly, Natasha L. Harvey, Hiroshi Kawabe, Oded Kleifeld, Sophie Wiszniak, Quenten Schwarz   +12 more
doaj   +2 more sources

Integrative proteomics reveals the role of E3 ubiquitin ligase SYVN1 in hepatocellular carcinoma metastasis

Cancer Communications, 2021
Background Tumor metastasis is a major factor for poor prognosis of hepatocellular carcinoma (HCC), but the relationship between ubiquitination and metastasis need to be studied more systematically.
Feiyang Ji, Menghao Zhou, Zeyu Sun, Zhengyi Jiang, Huihui Zhu, Zhongyang Xie, Xiaoxi Ouyang, Lingjian Zhang, Lanjuan Li   +8 more
doaj   +2 more sources

Proteome and ubiquitinome analyses of the brain cortex in K18-hACE2 mice infected with SARS-CoV-2 [PDF]

iScience
Summary: Clinical research indicates that SARS-CoV-2 infection is linked to several neurological consequences, and the virus is still spreading despite the availability of vaccinations and antiviral medications. To determine how hosts respond to SARS-CoV-
Qiaochu Wang, Wanjun Peng, Yehong Yang, Yue Wu, Rong Han, Tao Ding, Xutong Zhang, Jiangning Liu, Juntao Yang, Jiangfeng Liu   +9 more
doaj   +2 more sources

Proteomic and ubiquitinome analysis reveal that microgravity affects glucose metabolism of mouse hearts by remodeling non-degradative ubiquitination [PDF]

PLoS ONE
Long-term exposure to a microgravity environment leads to structural and functional changes in hearts of astronauts. Although several studies have reported mechanisms of cardiac damage under microgravity conditions, comprehensive research on changes at ...
Xin Zhang, Xuemei Zhou, Zhiwei Tu, Lihua Qiang, Zhe Lu, Yuping Xie, Cui Hua Liu, Lingqiang Zhang, Yesheng Fu   +8 more
doaj   +3 more sources

USP5 Promotes Ripretinib Resistance in Gastrointestinal Stromal Tumors by MDH2 Deubiquition

Advanced Science
Ripretinib, a broad‐spectrum inhibitor of the KIT and PDGFRA receptor tyrosine kinases, is designated as a fourth‐line treatment for gastrointestinal stromal tumor (GIST). It is tailored for patients resistant to imatinib, sunitinib, and regorafenib.
Haoyu Sun, Zhiwei Cui, Chao Li, Zhishuang Gao, Jun Xu, Yibo Bian, Tianhao Gu, Jianan Zhang, Tengyun Li, Qianzheng Zhou, Dinghua Yang, Zhongyuan He, Bowen Li, Fengyuan Li, Zekuan Xu, Hao Xu   +15 more
doaj   +2 more sources

Insights into ubiquitinome dynamics in the host‒pathogen interplay during Francisella novicida infection [PDF]

Cell Communication and Signaling
Ubiquitination functions as an important posttranslational modification for orchestrating inflammatory immune responses and cell death during pathogenic infection.
Luyu Yang, Yanfeng Li, Qingqing Xie, Tao Xu, Xiaopeng Qi   +4 more
doaj   +2 more sources

VCPIP1 drives diabetic cardiomyopathy by deubiquitinating AMPKγ1 and preventing AMPKα-γ subunit assembly in cardiomyocytes [PDF]

Signal Transduction and Targeted Therapy
Protein ubiquitination modifications contribute to cardiomyocyte homeostasis and pathophysiology in diabetic cardiomyopathy (DCM). Yet the roles of deubiquitinating enzymes (DUBs) in DCM remain poorly defined.
Xue Han, Zhuqi Huang, Guoxuan Liu, Yanan Liu, Weiqi Li, Jianing Zheng, Jie Tong, Mingyang He, Yurou Wu, Ze Li, Wu Luo, Qiaojuan Shi, Huazhong Ying, Guang Liang   +13 more
doaj   +2 more sources

Aspirin inhibits proteasomal degradation and promotes α-synuclein aggregate clearance through K63 ubiquitination [PDF]

Nature Communications
Aspirin is a potent lysine acetylation inducer, but its impact on lysine ubiquitination and ubiquitination-directed protein degradation is unclear. Herein, we develop the reversed-pulsed-SILAC strategy to systematically profile protein degradome in ...
Jing Gao, Yang Liu, Chenfang Si, Rui Guo, Shouqiao Hou, Xiaosong Liu, Houfang Long, Di Liu, Daichao Xu, Zai-Rong Zhang, Cong Liu, Bing Shan, Christoph W. Turck, Kaiwen He, Yaoyang Zhang   +14 more
doaj   +2 more sources

Use of a High-Affinity Ubiquitin-Binding Domain to Detect and Purify Ubiquitinated Substrates and Their Interacting Proteins

Bio-Protocol
OtUBD is a high-affinity ubiquitin-binding domain (UBD) derived from a large protein produced by the microorganism Orientia tsutsugamushi. The following protocol describes a step-by-step process for the enrichment of ubiquitinated proteins from baker'
Nitu Saha, Mengwen Zhang, Mark Hochstrasser   +2 more
doaj   +2 more sources

A computational tool to infer enzyme activity using post-translational modification profiling data [PDF]

Communications Biology
Enzymes play a pivotal role in orchestrating complex cellular responses to external stimuli and environmental changes through signal transduction pathways.
Dehui Kong, Aijun Zhang, Ling Li, Zuo-Fei Yuan, Yingxue Fu, Long Wu, Ashutosh Mishra, Anthony A. High, Junmin Peng, Xusheng Wang   +9 more
doaj   +2 more sources