Results 21 to 30 of about 274,920 (356)

Global Screening of LUBAC and OTULIN Interacting Proteins by Human Proteome Microarray

Frontiers in Cell and Developmental Biology, 2021
Linear ubiquitination is a reversible posttranslational modification, which plays key roles in multiple biological processes. Linear ubiquitin chain assembly complex (LUBAC) catalyzes linear ubiquitination, while the deubiquitinase OTULIN (OTU ...
Lijie Zhou, Lijie Zhou, Yingwei Ge, Yesheng Fu, Bo Wu, Yong Zhang, Lei Li, Chun-Ping Cui, Siying Wang, Lingqiang Zhang   +9 more
doaj   +1 more source

Developing Targeted Therapies That Exploit Aberrant Histone Ubiquitination in Cancer

Cells, 2019
Histone ubiquitination is a critical epigenetic mechanism regulating DNA-driven processes such as gene transcription and DNA damage repair. Importantly, the cellular machinery regulating histone ubiquitination is frequently altered in cancers.
Lucile M-P Jeusset, Kirk J McManus
doaj   +1 more source

Quantitative Ubiquitylomic Analysis of the Dynamic Changes and Extensive Modulation of Ubiquitylation in Papaya During the Fruit Ripening Process

Frontiers in Plant Science, 2022
Lysine ubiquitination is a highly conserved post-translational modification with diverse biological functions. However, there is little available information on lysine ubiquitination of non-histone proteins in papaya (Carica papaya L.).
Yuxing Mo, Bian Jiang, Jingxin Huo, Jiayi Lu, Xiaoyue Zeng, Yan Zhou, Tao Zhang, Min Yang, Yuerong Wei, Kaidong Liu   +9 more
doaj   +1 more source

Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin [PDF]

, 2010
Loss of the E3 ubiquitin ligase Parkin causes early onset Parkinson's disease, a neurodegenerative disorder of unknown etiology. Parkin has been linked to multiple cellular processes including protein degradation, mitochondrial homeostasis, and autophagy;
A. J. Whitworth, Bueler, Chu, Clark, De Vos, E. Ziviani, Exner, Fallon, Gasser, Geisler, Kim, Koshiba, Liesa, Lim, Moore, Morais, Mortiboys, Narendra, Park, Park, Popp, R. N. Tao, Sandebring, Shimura, Soubannier, Steinbrink, Tatsuta, Twig, Whitworth   +28 more
core   +2 more sources

mUbiSiDa: a comprehensive database for protein ubiquitination sites in mammals. [PDF]

PLoS ONE, 2014
MOTIVATION: Protein ubiquitination is one of the important post-translational modifications by attaching ubiquitin to specific lysine (K) residues in target proteins, and plays important regulatory roles in many cell processes.
Tong Chen, Tao Zhou, Bing He, Haiyan Yu, Xuejiang Guo, Xiaofeng Song, Jiahao Sha   +6 more
doaj   +1 more source

K48-Linked Ubiquitination Contributes to Nicotine-Augmented Bone Marrow-Derived Dendritic-Cell-Mediated Adaptive Immunity

Vaccines, 2021
K48-linked ubiquitination determining antigen degradation and the endosomal recruitments of p97 and Sec61 plays vital roles in dendritic cell (DC) cross-presentation.
Chun Fang Hu, Xiao Yan Liao, Dan Dan Xu, Yi Bin Ruan, Feng Guang Gao   +4 more
doaj   +1 more source

ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting. [PDF]

, 2012
The sorting of signaling receptors to lysosomes is an essential regulatory process in mammalian cells. During degradation, receptors are modified with ubiquitin and sorted by endosomal sorting complex required for transport (ESCRT)-0, -I, -II, and -III ...
Chen, Buxin, Dores, Michael R, Lin, Huilan, Meerloo, Timo, Montagne, William A, Paing, May M, Soh, Unice JK, Trejo, JoAnn   +7 more
core   +3 more sources

Translesion synthesis in mammalian cells [PDF]

, 2006
DNA damage blocks the progression of the replication fork. In order to circumvent the damaged bases, cells employ specialized low stringency DNA polymerases, which are able to carry out translesion synthesis (TLS) past different types of damage. The five
Alan R. Lehmann, Avkin, Avkin, Bienko, Garg, Gibbs, Gibbs, Gibbs, Guo, Haracska, Hoege, Huang, Johnson, Kannouche, Kannouche, King, Lehmann, Lemontt, Ling, Maher, Masutani, Masutani, McCulloch, Murakumo, Nair, Nakajima, Nelson, Nelson, Nelson, Ogi, Ohmori, Pages, Stelter, Tissier, Vidal, Watanabe   +35 more
core   +2 more sources

Artesunate Ameliorates APAP‐induced Liver Injury by Promoting NEDD4L‐Mediated Ubiquitination and Degradation of TXNIP

Advanced Science, EarlyView.
ABSTRACT Liver injury can lead to severe acute liver failure and even death in patients. Artesunate (ART), which is a derivative of artemisinin that has been approved by the FDA for the treatment of malaria, has significant regulatory effects on cell death and inflammation.
Zhe Zhang, Hongyi Zhang, H. Henry Guo, X. B. Zhang, Yidan Wang, Baoyin Wang, Tong Wang, Guokun Zhao, Qing Zhang, Fei Gao, Shuang Liang, Haibo Jiang, Yu Ding, Xiliang Du, Jiabao Zhang, Yi Zheng, Yu Li, Bao Yuan   +17 more
openalex   +2 more sources

A quantitative assay to monitor HSV-1 ICP0 ubiquitin ligase activity in vitro [PDF]

, 2015
The ubiquitin–proteasome system is an essential cellular process that plays a fundamental role in the regulation of protein stability. This pathway is tightly controlled by a sequential cascade of enzymatic steps that culminates in the formation of a ...
Boutell, Chris, Davido, David J.
core   +2 more sources