Ubiquitin in Motion: Structural Studies of the Ubiquitin-Conjugating Enzyme∼Ubiquitin Conjugate [PDF]
Biochemistry, 2011 Ubiquitination of proteins provides a powerful and versatile post-translational signal in the eukaryotic cell. The formation of a thioester bond between ubiquitin (Ub) and the active site of a ubiquitin-conjugating enzyme (E2) is critical for the transfer of Ub to substrates. Assembly of a functional ubiquitin ligase (E3) complex poised for Ub transfer
Jonathan N, Pruneda +4 more
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Multiple C-terminal Lysine residues target p53 for ubiquitin-proteasome-mediated degradation [PDF]
, 2000 This work was supported by the Medical Research Council, the Biotechnology and Biological Research Council, and the Cancer Research Campaign. D.P.L. is a Gibb fellow of the Cancer Research Campaign.In normal cells, p53 is maintained at a low level by ...
Lain, Sonia +6 more
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Computational prediction of protein ubiquitination sites mapping on Arabidopsis thaliana
, 2020 Among the protein post-translational modifications (PTMs), ubiquitination is considered as one of the most significant processes which can regulate the cellular functions and various diseases.
Ahmed, Fee Faysal +5 more
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In the family with ubiquitin [PDF]
The EMBO Reports, 2011 The Cold Spring Harbor meeting on 'The Ubiquitin Family', held in May 2011, brought together scientists from a wide range of fields under the umbrella of ubiquitin and ubiquitin-like protein structure, function and regulation.
Alexandru, Gabriela +2 more
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Global Screening of LUBAC and OTULIN Interacting Proteins by Human Proteome Microarray
Frontiers in Cell and Developmental Biology, 2021 Linear ubiquitination is a reversible posttranslational modification, which plays key roles in multiple biological processes. Linear ubiquitin chain assembly complex (LUBAC) catalyzes linear ubiquitination, while the deubiquitinase OTULIN (OTU ...
Lijie Zhou +9 more
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Mechanisms of mono- and poly-ubiquitination: Ubiquitination specificity depends on compatibility between the E2 catalytic core and amino acid residues proximal to the lysine [PDF]
, 2010 Ubiquitination involves the attachment of ubiquitin to lysine residues on substrate proteins or itself, which can result in protein monoubiquitination or polyubiquitination. Ubiquitin attachment to different lysine residues can generate diverse substrate-
Boris Sarcevic +7 more
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Developing Targeted Therapies That Exploit Aberrant Histone Ubiquitination in Cancer
Cells, 2019 Histone ubiquitination is a critical epigenetic mechanism regulating DNA-driven processes such as gene transcription and DNA damage repair. Importantly, the cellular machinery regulating histone ubiquitination is frequently altered in cancers.
Lucile M-P Jeusset, Kirk J McManus
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Frontiers in Plant Science, 2022 Lysine ubiquitination is a highly conserved post-translational modification with diverse biological functions. However, there is little available information on lysine ubiquitination of non-histone proteins in papaya (Carica papaya L.).
Yuxing Mo +9 more
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Histone crosstalk directed by H2B ubiquitination is required for chromatin boundary integrity [PDF]
, 2011 Genomic maps of chromatin modifications have provided evidence for the partitioning of genomes into domains of distinct chromatin states, which assist coordinated gene regulation.
West, A. +12 more
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mUbiSiDa: a comprehensive database for protein ubiquitination sites in mammals. [PDF]
PLoS ONE, 2014 MOTIVATION: Protein ubiquitination is one of the important post-translational modifications by attaching ubiquitin to specific lysine (K) residues in target proteins, and plays important regulatory roles in many cell processes.
Tong Chen +6 more
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