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Artificial Intelligence Transforming Post-Translational Modification Research [PDF]
BioengineeringPost-Translational Modifications (PTMs) are covalent changes to amino acids that occur after protein synthesis, including covalent modifications on side chains and peptide backbones.
Doo Nam Kim +8 more
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Post-Translational Modification Networks in Ferroptosis: Orchestrating Defense, Drug Resistance, and Therapeutic Opportunities in Hepatocellular Carcinoma [PDF]
Journal of Hepatocellular CarcinomaJie Chen,* Lingling Li,* Sufang Fang, Haitao Zhou Department of Hepatobiliary & Pancreatic Surgery, The Affiliated Yangming Hospital of Ningbo University (Yuyao People’s Hospital), Ningbo, Zhejiang, People’s Republic of China&ast ...
Chen J, Li L, Fang S, Zhou H
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Lactylation: The emerging frontier in post-translational modification
Frontiers in GeneticsLactate, a metabolic byproduct, has gained recognition as a highly influential signaling molecule. Lactylation, an emerging form of post-translational modification derived from lactate, plays a crucial role in numerous cellular processes such as ...
Zhou Lu +10 more
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Antioxidants, 2021 Post-translational modifications based on redox reactions “switch on-off” the biological activity of different downstream targets, modifying a myriad of processes and providing an efficient mechanism for signaling regulation in physiological and ...
Mabel Buelna-Chontal +4 more
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FIP200 Methylation by SETD2 Prevents Trim21-Induced Degradation and Preserves Autophagy Initiation
Cells, 2022 FIP200, also known as RB1CC1, is a protein that assembles the autophagy initiation complex. Its post-translational modifications and degradation mechanisms are unclear. Upon autophagy activation, we find that FIP200 is methylated at lysine1133 (K1133) by
Yuan Dai +5 more
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Post-translation modifications [PDF]
Current Opinion in Chemical Biology, 2009 The development of proteomics has been one of the great achievements in analytical chemical biology in the past ten years. The determination of the total protein constituents in biological samples has allowed new and unprecedented insights into cellular processes and diseases.
Carlito B, Lebrilla, Lara K, Mahal
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Glycosylation—The Most Diverse Post-Translational Modification
Biomolecules, 2022 This article is part of the Special Issue Glycosylation—The Most Diverse Post-Translational Modification [...]
Erika Staudacher +2 more
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Post-translational modifications of microtubules [PDF]
Journal of Cell Science, 2010 Microtubules – polymers of tubulin – perform essential functions, including regulation of cell shape, intracellular transport and cell motility. How microtubules are adapted to perform multiple diverse functions is not well understood. Post-translational modifications of tubulin subunits diversify the outer and luminal surfaces of microtubules and ...
Dorota, Wloga, Jacek, Gaertig
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Post-Translational Modifications of ATG4B in the Regulation of Autophagy
Cells, 2022 Autophagy plays a key role in eliminating and recycling cellular components in response to stress, including starvation. Dysregulation of autophagy is observed in various diseases, including neurodegenerative diseases, cancer, and diabetes.
Na Yeon Park, Doo Sin Jo, Dong-Hyung Cho
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Post-translational modification by SUMO [PDF]
Toxicology, 2010 Post-translational modifications (PTMs) are chemical alterations to a protein following translation, regulating stability and function. Reversible phosphorylation is an example of an important and well studied PTM involved in a number of cellular processes.
Hannoun, Zara +4 more
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