Lactylation: The emerging frontier in post-translational modification
Frontiers in GeneticsLactate, a metabolic byproduct, has gained recognition as a highly influential signaling molecule. Lactylation, an emerging form of post-translational modification derived from lactate, plays a crucial role in numerous cellular processes such as ...
Zhou Lu +10 more
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Tyrosine Sulfation as a Protein Post-Translational Modification
Molecules, 2015 Integration of inorganic sulfate into biological molecules plays an important role in biological systems and is directly involved in the instigation of diseases.
Yuh-Shyong Yang +5 more
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Post-Translational Modification and Subcellular Distribution of Rac1: An Update
Cells, 2018 Rac1 is a small GTPase that belongs to the Rho family. The Rho family of small GTPases is a subfamily of the Ras superfamily. The Rho family of GTPases mediate a plethora of cellular effects, including regulation of cytoarchitecture, cell size, cell ...
Zhixiang Wang
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Post-translational modification-regulating biomaterials for regeneration [PDF]
Bioactive MaterialsPost-translational modification (PTM) refers to covalent chemical alterations occurring on proteins after their biosynthesis, encompassing phosphorylation, acetylation, ubiquitination and hundreds of other documented variants.
Adilijiang Abudousu +7 more
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Precision post‐translational modification of PML defines neuroblastoma clinical behaviour [PDF]
Clinical and Translational MedicineBackground Promyelocytic leukaemia protein (PML), a key regulator of nuclear architecture and cellular homeostasis, is increasingly recognised for its tumour‐suppressive functions.
Sreenidhi Mohanvelu +6 more
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Post-translational protein lactylation modification in health and diseases: a double-edged sword
Journal of Translational MedicineAs more is learned about lactate, it acts as both a product and a substrate and functions as a shuttle system between different cell populations to provide the energy for sustaining tumor growth and proliferation.
Hang Gong +4 more
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Post-Translational Modification Networks in Ferroptosis: Orchestrating Defense, Drug Resistance, and Therapeutic Opportunities in Hepatocellular Carcinoma [PDF]
Journal of Hepatocellular CarcinomaJie Chen,* Lingling Li,* Sufang Fang, Haitao Zhou Department of Hepatobiliary & Pancreatic Surgery, The Affiliated Yangming Hospital of Ningbo University (Yuyao People’s Hospital), Ningbo, Zhejiang, People’s Republic of China&ast ...
Chen J, Li L, Fang S, Zhou H
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Post-Translational Modification of WRKY Transcription Factors
PlantsPost-translational modifications (PTMs) of proteins are involved in numerous biological processes, including signal transduction, cell cycle regulation, growth and development, and stress responses. WRKY transcription factors (TFs) play significant roles
Xiangui Zhou, Zaojuan Lei, Pengtian An
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Antioxidants, 2021 Post-translational modifications based on redox reactions “switch on-off” the biological activity of different downstream targets, modifying a myriad of processes and providing an efficient mechanism for signaling regulation in physiological and ...
Mabel Buelna-Chontal +4 more
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FIP200 Methylation by SETD2 Prevents Trim21-Induced Degradation and Preserves Autophagy Initiation
Cells, 2022 FIP200, also known as RB1CC1, is a protein that assembles the autophagy initiation complex. Its post-translational modifications and degradation mechanisms are unclear. Upon autophagy activation, we find that FIP200 is methylated at lysine1133 (K1133) by
Yuan Dai +5 more
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