Results 1 to 10 of about 6,398,571 (341)
Post translational modification of Parkin [PDF]
Biology Direct, 2017 Mutations in the gene encoding for the E3 ubiquitin ligase Parkin are associated to a rare form of familiar autosomal recessive Parkinsonism. Despite decades of research on the Parkin protein, whose structure has been recently solved, little is known ...
J. Chakraborty +2 more
semanticscholar +4 more sources
Post-Translational Modification and Subcellular Distribution of Rac1: An Update
Cells, 2018 Rac1 is a small GTPase that belongs to the Rho family. The Rho family of small GTPases is a subfamily of the Ras superfamily. The Rho family of GTPases mediate a plethora of cellular effects, including regulation of cytoarchitecture, cell size, cell ...
Abdalla M. Abdrabou, Zhixiang Wang
semanticscholar +1 more source
Post-translational modification of OCT4 in breast cancer tumorigenesis
Cell Death and Differentiation, 2018 Recurrence and drug resistance of breast cancer are still the main reasons for breast cancer-associated deaths. Cancer stem cell (CSC) model has been proposed as a hypothesis for the lethality of breast cancer.
Yunhee Cho +10 more
semanticscholar +1 more source
Hematology Reports, 2011 In this study, we have examined the role of post-translational modification of the myeloid master regulator C/EBP by small ubiquitin-related modifier (SUMO).
William Hankey +5 more
doaj +1 more source
Cell Reports, 2016 Glycosylation is an essential post-translational modification that underlies many biological processes and diseases. α-dystroglycan (α-DG) is a receptor for matrix and synaptic proteins that causes muscular dystrophy and lissencephaly upon its abnormal ...
M. Kanagawa +13 more
semanticscholar +1 more source
Frontiers in Microbiology, 2016 The gut ecosystem with myriads of microorganisms and the high concentration of immune system cells can be considered as a separate organ on its own.
A. Lerner, R. Aminov, T. Matthias
semanticscholar +1 more source
Global Post-Translational Modification Discovery
Journal of Proteome Research, 2016 A new global post-translational modification (PTM) discovery strategy, G-PTM-D, is described. A proteomics database containing UniProt-curated PTM information is supplemented with potential new modification types and sites discovered from a first-round ...
Qiyao Li +6 more
semanticscholar +1 more source
Protein post-translational modification regulates HIV-1 latency
生物医学转化AIDS is a disease named acquired immunodeficiency syndrome, which caused by the human immunodeficiency virus (HIV). HIV can be divided into HIV type 1 (HIV-1) and HIV type 2 (HIV-2). HIV-1 is a global pandemic that has caused serious harm.
Wu Tong, Wang Tiantian, Deng Kai
doaj +1 more source
Research progress on the role of butyrylation modification in malignant tumors [PDF]
Jichu yixue yu linchuangButyrylation (Kbu), as an important post-translational modification (PTM) of proteins, precisely regulates various biological behaviors of tumor cells by modulating the structure and function of proteins.
SHI Dongxue, WANG Ruihan, LYU Beibei, LIN Xiaoyan
doaj +1 more source
Molecular & Cellular Proteomics, 2016 Intracellular GlcNAcylation of Ser and Thr residues is a well-known and widely investigated post-translational modification. This post-translational modification has been shown to play a significant role in cell signaling and in many regulatory processes
Jason C. Maynard +2 more
semanticscholar +1 more source