Results 31 to 40 of about 267,024 (262)

Regulation of Lignin Biosynthesis by Post-translational Protein Modifications

Frontiers in Plant Science, 2020
Post-translational modification of proteins exerts essential roles in many biological processes in plants. The function of these chemical modifications has been extensively characterized in many physiological processes, but how these modifications ...
Daniel B. Sulis, Jack P. Wang
doaj   +1 more source

Post-translational modifications and their implications in cancer

Frontiers in Oncology, 2023
Post-translational modifications (PTMs) are crucial regulatory mechanisms that alter the properties of a protein by covalently attaching a modified chemical group to some of its amino acid residues. PTMs modulate essential physiological processes such as signal transduction, metabolism, protein localization, and turnover and have clinical relevance in ...
Hashnu Dutta, Hashnu Dutta, Nishant Jain, Nishant Jain   +3 more
openaire   +3 more sources

Post-translational modification of RAS proteins

Current Opinion in Structural Biology, 2021
Mutations of RAS genes drive cancer more frequently than any other oncogene. RAS proteins integrate signals from a wide array of receptors and initiate downstream signaling through pathways that control cellular growth. RAS proteins are fundamentally binary molecular switches in which the off/on state is determined by the binding of GDP or GTP ...
Sharon L, Campbell, Mark R, Philips
openaire   +2 more sources

Evaluating Mechanisms of IDH1 Regulation through Site-Specific Acetylation Mimics

Biomolecules, 2021
Isocitrate dehydrogenase (IDH1) catalyzes the reversible NADP+-dependent oxidation of isocitrate to α-ketoglutarate (αKG). IDH1 mutations, primarily R132H, drive > 80% of low-grade gliomas and secondary glioblastomas and facilitate the NADPH-dependent ...
Joi Weeks, Alexandra I. Strom, Vinnie Widjaja, Sati Alexander, Dahra K. Pucher, Christal D. Sohl   +5 more
doaj   +1 more source

α-TubK40me3 is required for neuronal polarization and migration by promoting microtubule formation

Nature Communications, 2021
Post-translational modifications of tubulins regulate microtubule properties and neural development. Here, the authors report that one such post-translational modification, α-TubK40me3, is required for neuronal polarization and migration by promoting ...
Xuan Xie, Shaogang Wang, Mingyi Li, Lei Diao, Xingyu Pan, Jijun Chen, Weiguo Zou, Xu Zhang, Wenfeng Feng, Lan Bao   +9 more
doaj   +1 more source

Post-Translational Modifications and Diabetes

Biomolecules
Diabetes and its associated complications have increasingly become major challenges for global healthcare. The current therapeutic strategies involve insulin replacement therapy for type 1 diabetes (T1D) and small-molecule drugs for type 2 diabetes (T2D).
Chiranjeev Sharma, Abu Hamza, Emily Boyle, Dickson Donu, Yana Cen   +4 more
openaire   +3 more sources

Clathrin Heavy Chain Knockdown Impacts CXCR4 Signaling and Post-translational Modification

Frontiers in Cell and Developmental Biology, 2019
Recent research has implicated endocytic pathways as important regulators of receptor signaling. However, the role of endocytosis in regulating chemokine CXC receptor 4 (CXCR4) signaling remains largely unknown.
Maxwell S. DeNies, Luciana K. Rosselli-Murai, Santiago Schnell, Santiago Schnell, Santiago Schnell, Allen P. Liu, Allen P. Liu, Allen P. Liu, Allen P. Liu   +8 more
doaj   +1 more source

Post-translational modifications in circadian rhythms [PDF]

Trends in Biochemical Sciences, 2009
The pace has quickened in circadian biology research. In particular, an abundance of results focused on post-translational modifications (PTMs) is sharpening our view of circadian molecular clockworks. PTMs affect nearly all aspects of clock biology; in some cases they are essential for clock function and in others, they provide layers of regulatory ...
Arun, Mehra, Christopher L, Baker, Jennifer J, Loros, Jay C, Dunlap   +3 more
openaire   +2 more sources

Post-translational modification-regulating biomaterials for regeneration

Bioactive Materials
Post-translational modification (PTM) refers to covalent chemical alterations occurring on proteins after their biosynthesis, encompassing phosphorylation, acetylation, ubiquitination and hundreds of other documented variants.
Adilijiang Abudousu, Yunkai Tang, Baikun Liu, Lei Xiang, Zhen Wang, Yihan Li, Ding Zhao, Wenguo Cui   +7 more
doaj   +1 more source

Tracking Health Related Quality of Life From Diagnosis to Follow‐Up Among Australian Children With Acute Lymphoblastic Leukaemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Acute lymphoblastic leukaemia (ALL) is one of the most treatable forms of paediatric cancer; however, there is a substantial burden of treatment‐related toxicities (TRTs). In addition, the long‐term changes in children's health‐related quality of life (HRQoL) due to toxic treatments are not well understood.
Clare Ghows, Clarissa E. Schilstra, Karen McCleary, Nancy E. Briggs, Rishi S. Kotecha, Richard De Abreu Lourenco, Shanti Ramachandran, Ruelleyn Cockcroft, Rachel Conyers, Siobhan Cross, Luciano Dalla‐Pozza, Peter Downie, Tamas Revesz, Michael Osborn, Frank Alvaro, Claire E. Wakefield, Glenn M. Marshall, Toby Trahair, Marion K. Mateos, Joanna E. Fardell   +19 more
wiley   +1 more source