Results 31 to 40 of about 6,398,571 (341)
A global view of the human post-translational modification landscape
Biochemical Journal, 2023 Post-translational modifications (PTMs) provide a rapid response to stimuli, finely tuning metabolism and gene expression and maintain homeostasis. Advances in mass spectrometry over the past two decades have significantly expanded the list of known PTMs
Naoya Kitamura, J. Galligan
semanticscholar +1 more source
Post-translation modifications [PDF]
Current Opinion in Chemical Biology, 2009 The development of proteomics has been one of the great achievements in analytical chemical biology in the past ten years. The determination of the total protein constituents in biological samples has allowed new and unprecedented insights into cellular processes and diseases.
Carlito B, Lebrilla, Lara K, Mahal
openaire +2 more sources
Nucleic Acids Research, 2021 Faithful genome integrity maintenance plays an essential role in cell survival. Here, we identify the RNA demethylase ALKBH5 as a key regulator that protects cells from DNA damage and apoptosis during reactive oxygen species (ROS)-induced stress. We find
Fang Yu +8 more
semanticscholar +1 more source
Signal Transduction and Targeted Therapy, 2021 More and more in-depth studies have revealed that the occurrence and development of tumors depend on gene mutation and tumor heterogeneity. The most important manifestation of tumor heterogeneity is the dynamic change of tumor microenvironment (TME ...
Wen Li +4 more
semanticscholar +1 more source
Post-translational modifications of microtubules [PDF]
Journal of Cell Science, 2010 Microtubules – polymers of tubulin – perform essential functions, including regulation of cell shape, intracellular transport and cell motility. How microtubules are adapted to perform multiple diverse functions is not well understood. Post-translational modifications of tubulin subunits diversify the outer and luminal surfaces of microtubules and ...
Dorota, Wloga, Jacek, Gaertig
openaire +4 more sources
Decoding Post-Translational Modification Crosstalk With Proteomics
Molecular & Cellular Proteomics, 2021 Post-translational modification (PTM) of proteins allows cells to regulate protein functions, transduce signals and respond to perturbations. PTMs expand protein functionality and diversity, which leads to increased proteome complexity.
Mario Leutert, S. Entwisle, J. Villén
semanticscholar +1 more source
Post-translational modifications of tubulin [PDF]
Current Biology, 2014 Microtubules are the largest filamentous components of the eukaryotic cytoskeleton. In spite of their extraordinary level of structural conservation, microtubules fulfill a vast range of different functions in cells. How this functional diversity is achieved remains an open question; however, recent advances point towards post-translational ...
Magiera, Maria M., Janke, Carsten
openaire +2 more sources
Prediction of histone post-translational modification patterns based on nascent transcription data
Nature Genetics, 2022 The role of histone modifications in transcription remains incompletely understood. Here, we examine the relationship between histone modifications and transcription using experimental perturbations combined with sensitive machine-learning tools ...
Zhong Wang +13 more
semanticscholar +1 more source
Post-Translational Modifications of ATG4B in the Regulation of Autophagy
Cells, 2022 Autophagy plays a key role in eliminating and recycling cellular components in response to stress, including starvation. Dysregulation of autophagy is observed in various diseases, including neurodegenerative diseases, cancer, and diabetes.
Na Yeon Park, Doo Sin Jo, Dong-Hyung Cho
doaj +1 more source
Core Components of Abscisic Acid Signaling and Their Post-translational Modification
Frontiers in Plant Science, 2022 Abscisic acid (ABA) is a major phytohormone that regulates plant growth, development, and abiotic/biotic stress responses. Under stress, ABA is synthesized in various plant organs, and it plays roles in diverse adaptive processes, including seed dormancy,
Junsub Lim, Chae-Woo Lim, Sung Chul Lee
semanticscholar +1 more source