Results 31 to 40 of about 468,017 (309)
Post translational modification of Parkin [PDF]
Biology Direct, 2017 Mutations in the gene encoding for the E3 ubiquitin ligase Parkin are associated to a rare form of familiar autosomal recessive Parkinsonism. Despite decades of research on the Parkin protein, whose structure has been recently solved, little is known about the specific signalling pathways that lead to Parkin activation.
Chakraborty, Joy +2 more
openaire +3 more sources
The rational parameterisation theorem for multisite post-translational modification systems [PDF]
, 2009 Post-translational modification of proteins plays a central role in cellular regulation but its study has been hampered by the exponential increase in substrate modification forms (“modforms”) with increasing numbers of sites.
Gunawardena, Jeremy, Thomson, Matthew
core +1 more source
The interplay of post-translational modification and gene therapy [PDF]
, 2016 Several proteins interact either to activate or repress the expression of other genes during transcription. Based on the impact of these activities, the proteins can be classified into readers, modifier writers, and modifier erasers depending on ...
Azuh, Dominic E. +4 more
core +2 more sources
Post-translational modifications of tubulin [PDF]
Current Biology, 2014 Microtubules are the largest filamentous components of the eukaryotic cytoskeleton. In spite of their extraordinary level of structural conservation, microtubules fulfill a vast range of different functions in cells. How this functional diversity is achieved remains an open question; however, recent advances point towards post-translational ...
Magiera, Maria M., Janke, Carsten
openaire +2 more sources
BMC Genomics, 2017 Background Post-translational modification (PTM) of proteins is central to many cellular processes across all domains of life, but despite decades of study and a wealth of genomic and proteomic data the biological function of many PTMs remains unknown ...
Colin W. Brown +6 more
doaj +1 more source
Diagnostics, 2023 The present review aims to describe the state of the art of research studies investigating the citrullination post-translational modification in adult and pediatric brain tumors.
Diana Valeria Rossetti +4 more
doaj +1 more source
Smc5/6: a link between DNA repair and unidirectional replication? [PDF]
, 2008 Of the three structural maintenance of chromosome (SMC) complexes, two directly regulate chromosome dynamics. The third, Smc5/6, functions mainly in homologous recombination and in completing DNA replication.
A Losada +46 more
core +1 more source
Casein Kinase II Phosphorylation of Spt6 Enforces Transcriptional Fidelity by Maintaining Spn1-Spt6 Interaction [PDF]
, 2018 Spt6 is a histone chaperone that associates with RNA polymerase II and deposits nucleosomes in the wake of transcription. Although Spt6 has an essential function in nucleosome deposition, it is not known whether this function is influenced by post ...
Adams, Alexander T. +10 more
core +1 more source
RanBP2-Mediated SUMOylation Promotes Human DNA Polymerase Lambda Nuclear Localization and DNA Repair [PDF]
, 2020 Cellular DNA is under constant attack by a wide variety of agents, both endogenous and exogenous. To counteract DNA damage, human cells have a large collection of DNA repair factors. Among them, DNA polymerase lambda (Polλ) stands out for its versatility,
Cortés Ledesma, Felipe +4 more
core +1 more source
α-TubK40me3 is required for neuronal polarization and migration by promoting microtubule formation
Nature Communications, 2021 Post-translational modifications of tubulins regulate microtubule properties and neural development. Here, the authors report that one such post-translational modification, α-TubK40me3, is required for neuronal polarization and migration by promoting ...
Xuan Xie +9 more
doaj +1 more source