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Lactate metabolism-driven lactylation: paradoxical modulation of intestinal inflammation and malignancy [PDF]
Journal of Translational MedicineBackground Intestinal inflammation and malignancy represent two critical pathological states in the gut that severely impair patients’ quality of life. Understanding their molecular mechanisms holds significant therapeutic implications.
Junting Liu +6 more
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Lactylation in pulmonary fibrosis: current understanding and challenges [PDF]
Journal of Translational MedicineBackground Pulmonary fibrosis (PF) is a progressive, chronic lung disease, which is accompanied by epithelial cell damage, fibroblast activation, and macrophage polarization; the fibrotic niche is primarily composed of these three cell types.
Bo Li +5 more
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Glycolysis enzymes and cellular lactylation in tumour [PDF]
Clinical and Translational MedicineCellular lactylation, a recently identified post‐translational modification, has emerged as a crucial regulator in various biological processes, particularly in cancer.
Chenyuan Dai, Lihua Wang
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A lactylation modification-related prediction model for the diagnosis of ulcerative colitis based on machine learning [PDF]
Frontiers in ImmunologyBackgroundLactylation modification serves as a critical link between metabolic reprogramming and epigenetic regulation, playing a significant role in the progression of both malignant tumors and inflammatory diseases.
Jian Liu +3 more
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Advanced ScienceHistone lactylation is a metabolic stress‐related histone modification. However, the role of histone lactylation in the development of sepsis‐associated acute kidney injury (SA‐AKI) remains unclear.
Liyan Cui
exaly +2 more sources
Progress of Research on the Metabolic Regulation of Lactylation in Muscle Tissues and Its Disease Associations [PDF]
BiomoleculesLactylation serves as a vital link between cellular metabolism and epigenetic regulation and plays a pivotal role in muscle biology. Muscle tissue is the primary site of lactate production; its unique metabolic environment confers dynamism, specificity ...
Zhihang Wang +7 more
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BMC Biology, 2023 Background The aim of study was to observe the effect of increased lactate levels during high-intensity interval training (HIIT) on protein lactylation, identify the target protein, and investigate the regulatory effect of lactylation on the function of ...
Xuefei Chen +7 more
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Deciphering novel enzymatic and non-enzymatic lysine lactylation in Salmonella
Emerging Microbes and InfectionsLysine lactylation, a novel post-translational modification, is involved in multiple cellular processes. The role of lactylation remains largely unknown, especially in bacteria.
Chuanzhen Zhang +8 more
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HeliyonBackground: Lactylation is a significant post-translational modification bridging the gap between cancer epigenetics and metabolic reprogramming. However, the association between lactylation and prognosis, tumor microenvironment (TME), and response to ...
Zhixuan Wu +7 more
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Genome Biology, 2021 Background Histone lactylation, a metabolic stress-related histone modification, plays an important role in the regulation of gene expression during M1 macrophage polarization.
Jie Yu +6 more
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