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Über Lactyl‐p‐aminobenzoesäure [PDF]

Berichte der deutschen chemischen Gesellschaft, 1917
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A pan-cancer multi-omics analysis of lactylation genes associated with tumor microenvironment and cancer development

Heliyon
Background: Lactylation is a significant post-translational modification bridging the gap between cancer epigenetics and metabolic reprogramming. However, the association between lactylation and prognosis, tumor microenvironment (TME), and response to ...
Zhixuan Wu, Haodong Wu, Yinwei Dai, Ziqiong Wang, Hui Han, Yanyan Shen, Rongrong Zhang, Xiaowu Wang   +7 more
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Lactylation and antitumor immunity

Frontiers in Immunology
Lactylation, a recently discovered post-translational modification (PTM), plays a critical role in cancer biology. Warburg effect induces lactate accumulation, which serves as a metabolic end-product and intercellular signaling mediator within the tumor microenvironment (TME).
Yang, Biao, Li, Lingyu, Shi, Dongmei, Zhong, Tao, Xiong, Huabao   +4 more
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The Role of Histone Lactylation in Diseases and Intervention by Traditional Chinese Medicine

Shengwu huaxue yu shengwu wuli jinzhan
Histone lactylation is a recently identified post-translational modification, wherein lactate mediates the enzymatic addition of lactyl groups to lysine residues on histones.
ZHANG Xin, DU Jie, LI Zhao-Huan, GAO Feng   +3 more
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Re-evaluating the mechanism of histone lactylation

, 2020
Recent work by Zhang et al. published in Nature identified a unique non-metabolic role of the glycolysis end-product lactate, in post-translational lactylation of histones.
Florian Muller, Yasaman Barekatain, Sunada Khadka   +2 more
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Lactylation and human disease

Expert Reviews in Molecular Medicine
Abstract Background Lactylation, a new epigenetic modification, is an important way in which lactate exerts physiological functions. There is a close relationship between increased lactylations caused by lactate and glycolysis, which can interact and play a role in disease through lactate as an intermediate mediator.
Linlin Wan, HuiJuan Zhang, Jialing Liu, Qian He, Jiumei Zhao, Chenglong Pan, Kepu Zheng, Yu Tang   +7 more
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Lactate and lactylation in cancer

Signal Transduction and Targeted Therapy
Abstract Accumulated evidence has implicated the diverse and substantial influence of lactate on cellular differentiation and fate regulation in physiological and pathological settings, particularly in intricate conditions such as cancer. Specifically, lactate has been demonstrated to be pivotal in molding the tumor microenvironment (TME ...
Jie Chen, Ziyue Huang, Ya Chen, Hao Tian, Peiwei Chai, Yongning Shen, Yiran Yao, Shiqiong Xu, Shengfang Ge, Renbing Jia   +9 more
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Glycolysis enzymes and cellular lactylation in tumour

Clinical and Translational Medicine
Cellular lactylation, a recently identified post‐translational modification, has emerged as a crucial regulator in various biological processes, particularly in cancer.
Chenyuan Dai, Lihua Wang
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Predicting lymphoma prognosis using machine learning-based genes associated with lactylation

Translational Oncology
Background: Lactylation, a newly discovered PTM involving lactic acid, is linked to solid tumor proliferation and metastasis. Lymphoma patients exhibit high lactic acid levels, yet lactylation's role in lymphoma is underexplored.
Miao Zhu, Qin Xiao, Xinzhen Cai, Zhiyue Chen, Qingqing Shi, Xing Sun, Xiaoyan Xie, Mei Sun   +7 more
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Lactate-mediated lactylation in human health and diseases: Progress and remaining challenges

Journal of Advanced Research
Background: Lactate was once considered as metabolic waste for a long time. In 2019, Professor Zhao Yingming’s team from the University of Chicago found that lactate could also be used as a substrate to induce histone lactylation and regulate gene ...
Xue-ting Hu, Xiao-feng Wu, Jin-yi Xu, Xiang Xu   +3 more
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