Results 1 to 10 of about 7,170 (205)

Lactate metabolism and protein lactylation in programmed cell death: From novel mechanism to therapeutic strategies in human diseases [PDF]

Clinical and Translational Medicine
Protein lactylation is a recently identified post‐translational modification that reflects cellular metabolic status. It plays an important role in regulating gene expression and maintaining essential cellular functions.
Yue Chen, Xiwen Wang, Xiuping Wang, Na Lin, Wenjie Wang, Ruiqi Fu, Yutong Wu, Yi Liu, Hengwei Liu   +8 more
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Research progress on protein lactylation in female reproductive disease: molecular mechanisms, functions, and therapeutic implications [PDF]

Frontiers in Pharmacology
Female reproductive health depends on precisely coordinated metabolic, hormonal, immune, and epigenetic networks. Lactylation is a lactate-derived lysine post-translational modification that provides a direct mechanism by which glycolytic metabolism ...
Xiaoyang Shen, Xiaoyang Shen, Xiaoyang Shen, Yan Chen, Yan Chen, Yan Chen, Hongxia Deng, Hongxia Deng, Nannan Zhang, Nannan Zhang, Liangzhi Xu, Liangzhi Xu, Liangzhi Xu   +12 more
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When metabolic enzymes meet lactylation: a bidirectional dialogue in health and disease [PDF]

Frontiers in Cell and Developmental Biology
Lactate accumulation occurs in diverse physiological and pathological states, including hypoxia, ischemia, development, wound healing, immune activation, and cancer, where it functions as a key regulator of cellular energy metabolism, signal transduction,
Xiang Zhao, Xiang Zhao, Xiang Zhao, Jia-Hui Liu, Jia-Hui Liu, Kun-Yao Liu, Kun-Yao Liu, Guo-Chao Lin, Guo-Chao Lin, Xiao Liu, Xiao Liu, Zhen Wang, Xin Zhou, Xin Zhou, Xin Zhou   +14 more
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RHOA Lactylation at Oncogenic Hotspots Promotes Oncogenic Activity and Protein Stabilization

Molecular Cancer
Background Aberrant RHOA activation drives tumor progression, yet regulatory mechanisms beyond genetic mutations remain poorly defined. Lactylation, a lactate-derived post-translational modification, links metabolic reprogramming to oncogenesis, but its ...
Zhijun Dai, Qianhua Cao, Chenfang Dong
exaly   +2 more sources

Histone H3K18 and Ezrin Lactylation Promote Renal Dysfunction in Sepsis-Associated Acute Kidney Injury

Advanced Science
Histone lactylation is a metabolic stress‐related histone modification. However, the role of histone lactylation in the development of sepsis‐associated acute kidney injury (SA‐AKI) remains unclear.
Liyan Cui, Boxin Yang, Weimin Feng
exaly   +2 more sources

Lactylation of Mutation-Prone RAS Residues Mimics Oncogenic Mutations and Drives Constitutive Activation [PDF]

Cancer Communications
Background: Elevated expression of wild-type RAS contributes to tumorigenesis, yet the mechanisms underlying its mutation-independent hyperactivity remain unclear. Lactylation, a lactate-derived post-translational modification, has emerged as a regulator
Ruocen Liao, Chenglong Ma, Xingyu Chen, Longchang Bai, Qianhua Cao, Yu Zhang, Chenfang Dong   +6 more
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Deciphering novel enzymatic and non-enzymatic lysine lactylation in Salmonella

Emerging Microbes and Infections
Lysine lactylation, a novel post-translational modification, is involved in multiple cellular processes. The role of lactylation remains largely unknown, especially in bacteria.
Chuanzhen Zhang, Tao Zhou, Chengxi Li, Danni Wang, Jing Tao, Xiaocen Zhu, Jie Lu, Jinjing Ni, Yu-Feng Yao   +8 more
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A pan-cancer multi-omics analysis of lactylation genes associated with tumor microenvironment and cancer development

Heliyon
Background: Lactylation is a significant post-translational modification bridging the gap between cancer epigenetics and metabolic reprogramming. However, the association between lactylation and prognosis, tumor microenvironment (TME), and response to ...
Zhixuan Wu, Haodong Wu, Yinwei Dai, Ziqiong Wang, Hui Han, Yanyan Shen, Rongrong Zhang, Xiaowu Wang   +7 more
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The Role of Histone Lactylation in Diseases and Intervention by Traditional Chinese Medicine

Shengwu huaxue yu shengwu wuli jinzhan
Histone lactylation is a recently identified post-translational modification, wherein lactate mediates the enzymatic addition of lactyl groups to lysine residues on histones.
ZHANG Xin, DU Jie, LI Zhao-Huan, GAO Feng   +3 more
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Glycolysis enzymes and cellular lactylation in tumour

Clinical and Translational Medicine
Cellular lactylation, a recently identified post‐translational modification, has emerged as a crucial regulator in various biological processes, particularly in cancer.
Chenyuan Dai, Lihua Wang
doaj   +1 more source