Results 1 to 10 of about 5,491 (207)

Metabolic Reprogramming-Driven Lactylation: Emerging Mechanisms Linking DNA Damage Repair and Chemoresistance in Cancer [PDF]

Cells
Lactylation is an emerging lactate-derived post-translational modification that may link tumour metabolic reprogramming, epigenetic regulation and DNA damage repair. Enhanced glycolysis and lactate accumulation are common in many tumours, and lactate has
Lining Wang, Siyu Zhong, Jianan Zhao, Ligang Liu, Changyong Li   +4 more
doaj   +2 more sources

Lactate metabolism-driven lactylation: paradoxical modulation of intestinal inflammation and malignancy [PDF]

Journal of Translational Medicine
Background Intestinal inflammation and malignancy represent two critical pathological states in the gut that severely impair patients’ quality of life. Understanding their molecular mechanisms holds significant therapeutic implications.
Junting Liu, Yilong Liu, Hao Zhang, Zhaoshen Li, Xue Fang, Zixuan He, Yu Bai   +6 more
doaj   +2 more sources

Histone H3K18 and Ezrin Lactylation Promote Renal Dysfunction in Sepsis‐Associated Acute Kidney Injury

Advanced Science
Histone lactylation is a metabolic stress‐related histone modification. However, the role of histone lactylation in the development of sepsis‐associated acute kidney injury (SA‐AKI) remains unclear.
Liyan Cui
exaly   +2 more sources

High-intensity interval training induces lactylation of fatty acid synthase to inhibit lipid synthesis

BMC Biology, 2023
Background The aim of study was to observe the effect of increased lactate levels during high-intensity interval training (HIIT) on protein lactylation, identify the target protein, and investigate the regulatory effect of lactylation on the function of ...
Xuefei Chen, Wenhua Huang, Jingbo Zhang, Yanjun Li, Zheng Xing, Lanlan Guo, Hongfeng Jiang, Jing Zhang   +7 more
doaj   +1 more source

Deciphering novel enzymatic and non-enzymatic lysine lactylation in Salmonella

Emerging Microbes and Infections
Lysine lactylation, a novel post-translational modification, is involved in multiple cellular processes. The role of lactylation remains largely unknown, especially in bacteria.
Chuanzhen Zhang, Tao Zhou, Chengxi Li, Danni Wang, Jing Tao, Xiaocen Zhu, Jie Lu, Jinjing Ni, Yu-Feng Yao   +8 more
doaj   +1 more source

A pan-cancer multi-omics analysis of lactylation genes associated with tumor microenvironment and cancer development

Heliyon
Background: Lactylation is a significant post-translational modification bridging the gap between cancer epigenetics and metabolic reprogramming. However, the association between lactylation and prognosis, tumor microenvironment (TME), and response to ...
Zhixuan Wu, Haodong Wu, Yinwei Dai, Ziqiong Wang, Hui Han, Yanyan Shen, Rongrong Zhang, Xiaowu Wang   +7 more
doaj   +1 more source

The Role of Histone Lactylation in Diseases and Intervention by Traditional Chinese Medicine

Shengwu huaxue yu shengwu wuli jinzhan
Histone lactylation is a recently identified post-translational modification, wherein lactate mediates the enzymatic addition of lactyl groups to lysine residues on histones.
ZHANG Xin, DU Jie, LI Zhao-Huan, GAO Feng   +3 more
doaj   +1 more source

Predicting lymphoma prognosis using machine learning-based genes associated with lactylation

Translational Oncology
Background: Lactylation, a newly discovered PTM involving lactic acid, is linked to solid tumor proliferation and metastasis. Lymphoma patients exhibit high lactic acid levels, yet lactylation's role in lymphoma is underexplored.
Miao Zhu, Qin Xiao, Xinzhen Cai, Zhiyue Chen, Qingqing Shi, Xing Sun, Xiaoyan Xie, Mei Sun   +7 more
doaj   +1 more source

Glycolysis enzymes and cellular lactylation in tumour

Clinical and Translational Medicine
Cellular lactylation, a recently identified post‐translational modification, has emerged as a crucial regulator in various biological processes, particularly in cancer.
Chenyuan Dai, Lihua Wang
doaj   +1 more source

Lactate-mediated lactylation in human health and diseases: Progress and remaining challenges

Journal of Advanced Research
Background: Lactate was once considered as metabolic waste for a long time. In 2019, Professor Zhao Yingming’s team from the University of Chicago found that lactate could also be used as a substrate to induce histone lactylation and regulate gene ...
Xue-ting Hu, Xiao-feng Wu, Jin-yi Xu, Xiang Xu   +3 more
doaj   +1 more source