Results 41 to 50 of about 7,170 (205)

Identification of lactylation related model to predict prognostic, tumor infiltrating immunocytes and response of immunotherapy in gastric cancer

Frontiers in Immunology, 2023
BackgroundThe epigenetic regulatory chemical lactate is a product of glycolysis. It can regulate gene expression through histone lactylation, thereby promoting tumor proliferation, metastasis, and immunosuppression.MethodsIn this study, a lactylation ...
Hao Yang, Xiaoming Zou, Shifeng Yang, Ange Zhang, Nana Li, Zhen Ma   +5 more
doaj   +1 more source

SIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis

Advanced Science, EarlyView.
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang, Caitao Dong, Yuchen Liu, Yuanquan Lou, Wenlong Lin, Sheng Li, Ziqi He   +6 more
wiley   +1 more source

Unraveling the role of lactylation in cell death and correlative diseases: a comprehensive review

Frontiers in Cell and Developmental Biology
Lactylation is a newly identified post-translational modification and an important biological function of lactate. Numerous pathological disorders, including cancer and autoimmune and inflammatory diseases, are regulated by lactylation.
Bowen Zhao, Yue Liu, Xinpei Shen, Yunxue Zhang, Qihang Cang, Yuan Fan, Yuan Fan, Yuan Fan, Yanting Wang, Yanting Wang, Yanting Wang   +10 more
doaj   +1 more source

Protein Lactylation in Cancer: From Mechanisms to Therapy [PDF]

MedComm (2020)
Increased glycolysis and lactate accumulation promote histone and nonhistone protein lactylation, linking tumor metabolic reprogramming to treatment adaptation. Lactylation enhances DNA repair, suppresses antitumor immunity, strengthens antioxidant defenses, and facilitates cell‐cycle checkpoint escape, collectively promoting resistance to chemotherapy,
Huang W, Hu P, Wang S, Zhang X, Ye Z, Chen S, Gao F, Chen Y, Yang Y.   +8 more
europepmc   +2 more sources

Lactylation‐Driven PROS1‐TYRO3‐CARF Signaling Promotes Therapy‐Induced Senescence Escape and Radioresistance in Meningioma

Advanced Science, EarlyView.
A glycolysis‐driven epigenetic switch promotes therapy resistance in meningioma. Increased lactate production enhances histone H3K27 lactylation, which activates PROS1 secretion. Secreted PROS1 engages TYRO3 signaling to degrade the senescence regulator CARF, allowing cancer cells to escape growth arrest.
Zhuohang Wang, Qixiang Zhang, Keman Liao, Xiaoyu Liu, Hongchi Zhang, Yunsheng Chen, Yuxiao Ma, Yikui Liu, Aoqian Xu, Yuhao Sun, Jiayi Chen, Liuguan Bian, Baofeng Wang   +12 more
wiley   +1 more source

Lactylation in cancer: Advances and opportunities for treatment resistance

Clinical and Translational Medicine
Background Lactylation, a recently identified post‐translational modification that utilizes lactic acidas a substrate, has emerged as an important regulator of gene expression andprotein function.
Keke Xu, Yiyi Shou, Ruiqi Liu, Hao Xiong, Xiaomeng Dai, Xuanwen Bao, Xiaoyan Chen, Luanluan Huang, Hailong Sheng, Haibo Zhang, Yanwei Lu   +10 more
doaj   +1 more source

Histone lactylation regulates macrophage polarization and metabolic homeostasis during hypoxic lung injury

Cell Reports
Summary: The M1-to-M2 macrophage phenotypic switch is critical for resolving inflammation and restoring homeostasis in hypoxic lung injury, but the underlying molecular mechanisms are unclear.
Xingwang Zhao, Mengjie Zhang, Jun Yin, Jingyi Liao, Denghui Li, Zhiqiang Tian, Yi You, Longlong Zhang, Bing Ni   +8 more
doaj   +1 more source

Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2

Advanced Science, EarlyView.
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang, Chuanzan Zhou, Jiaoyan He, Pengpeng Huang, Rong Zhang, Huan Hu, Meng Jiao, Linyi Hu, Feng Liu, Xiaolong Qi, Xiang He, Yunkai Yang, Y Eugene Chinn, Dechao Feng, Dahong Zhang, Qi Zhang   +15 more
wiley   +1 more source

The role of nonhistone lactylation in disease

Heliyon
In 2019, a novel post-translational modification termed lactylation was identified, which established a connection among lactate, transcriptional regulation and epigenetics. Lactate, which is traditionally viewed as a metabolic byproduct, is now recognized for its significant functional role, including modulating the tumor microenvironment, engaging in
Hao Yu, Tingting Zhu, Dongwen Ma, Xiaohan Cheng, Shengjia Wang, Yongzhong Yao   +5 more
openaire   +3 more sources

Lactylation Enhances the Activity of Lactate Dehydrogenase A and Promotes the Chemoresistance to Cisplatin Through Facilitating DNA Nonhomologous End Junction in Lung Adenocarcinoma

Advanced Science
Lactylation is a novel post‐translational modification closely related to the glycolytic process, but the regulatory mechanisms between lactylation and glycolysis are far from being elucidated.
Jizhuo Li, Wenze Xun, Xijie Wang, Ruiguang Luo, Qifan Hu, Zhaocai Zhou, Jian Yuan, Yanan Wang, Xiaorui Wan, Tao Zhao, Tianyu Han, Jian‐Bin Wang   +11 more
doaj   +1 more source