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Role of Histone Lactylation in Neurological Disorders [PDF]
International Journal of Molecular SciencesLactate is not only the end product of glycolysis but also plays a key role in epigenetic regulation. Recently, lactate-derived histone lactylation has been identified as a novel epigenetic modification that can directly influence gene transcription.
Jian-Nan Zhang
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Lactate and lysine lactylation of histone regulate transcription in cancer
HeliyonHistone lysine modifications were well-established epigenetic markers, with many types identified and extensively studied. The discovery of histone lysine lactylation had revealed a new form of epigenetic modification.
Yin Ku, Zhipeng Gong, Wenjing Zhou
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Non-histone lactylation: unveiling its functional significance [PDF]
Frontiers in Cell and Developmental BiologyLactylation, a newly discovered protein posttranslational modification (PTM) in 2019, primarily occurs on lysine residues. Lactylation of histones was initially identified, and subsequent studies have increasingly demonstrated its widespread presence on non-histone proteins. Recently, high-throughput proteomics studies have identified a large number of
Pusong Shi +10 more
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Histone lactylation: epigenetic mark of glycolytic switch
Trends in Genetics, 2022 Histone lactylation and acetylation compete for epigenetic modification of lysines and mark the levels of lactates and acetyl-CoA. Whether pyruvate is committed to lactate or acetyl-CoA generation as the outlet of glycolysis determines cell fate towards malignancy or not. Taking control over the glycolytic switch as marked by lactylation suggests novel
Dai, Xiaofeng +3 more
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Metabolic regulation of gene expression by histone lactylation [PDF]
Nature, 2019 The Warburg effect, which originally described increased production of lactate in cancer, is associated with diverse cellular processes such as angiogenesis, hypoxia, polarization of macrophages and activation of T cells. This phenomenon is intimately linked to several diseases including neoplasia, sepsis and autoimmune diseases1,2.
Jun Ding, Sangkyu Lee
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Biochemistry and regulation of histone lysine l-lactylation
Nature Reviews Molecular Cell BiologyHistone L-lactylation is a newly identified, metabolism-linked short-chain Lys acylation. Mounting evidence indicates that Lys L-lactylation has key roles in transcription regulation and many other cellular processes and is associated with diverse pathophysiological changes.
Philip A Cole, Hening Lin, Xinlei Sheng
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Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis
Cell MetabolismHistone lysine lactylation is a physiologically and pathologically relevant epigenetic pathway that can be stimulated by the Warburg effect-associated L-lactate. Nevertheless, the mechanism by which cells use L-lactate to generate lactyl-coenzyme A (CoA) and how this process is regulated remains unknown.
Yingming Zhao, Xuelian Ren, Lingting Li
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Advanced ScienceHistone lactylation is a metabolic stress‐related histone modification. However, the role of histone lactylation in the development of sepsis‐associated acute kidney injury (SA‐AKI) remains unclear.
Liyan Cui, Weimin Feng, Zhongxin Li
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DPF2 reads histone lactylation to drive transcription and tumorigenesis
Proceedings of the National Academy of Sciences of the United States of AmericaLysine lactylation (Kla) is a new type of histone mark implicated in the regulation of various functional processes such as transcription. However, how this histone mark acts in cancers remains unexplored due in part to a lack of knowledge about its reader proteins.
Kai Zhang, Aiyuan Wang, Ziping Niu
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Genome Biology, 2021 Background Histone lactylation, a metabolic stress-related histone modification, plays an important role in the regulation of gene expression during M1 macrophage polarization.
Jie Yu +6 more
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