Role of Histone Lactylation in Neurological Disorders. [PDF]
Int J Mol SciLactate is not only the end product of glycolysis but also plays a key role in epigenetic regulation. Recently, lactate-derived histone lactylation has been identified as a novel epigenetic modification that can directly influence gene transcription.
Zhang YM, Yang F, Li Q, Zhang JN.
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Lactate and lysine lactylation of histone regulate transcription in cancer
HeliyonHistone lysine modifications were well-established epigenetic markers, with many types identified and extensively studied. The discovery of histone lysine lactylation had revealed a new form of epigenetic modification.
Yunhao Yang +5 more
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Lysine lactylation in diseases: beyond histone lactylation. [PDF]
Cell Death DisAbstract Lactylation, a recently identified post-translational modification, was initially characterized as lysine residue modification in histone subunits that regulates gene transcription via epigenetic mechanisms. Elevated intracellular lactate has been shown to drive histone lysine lactylation (Kla), establishing its association ...
Liu Y +6 more
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Histone lactylation maintains bovine early embryo development via regulating embryonic genome activation [PDF]
Journal of Animal Science and BiotechnologyBackground Early embryo loss is an important factor affecting the reproductive capacity of cattle. Recent studies have revealed that during the process of embryonic genome activation (EGA), epigenetic modification, such as histone lactylation remodeling,
Wenjie Yu +10 more
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Metabolic reprogramming regulates histone lactylation during zebrafish caudal fin regeneration [PDF]
iScienceSummary: Tissue regeneration relies on precise molecular mechanisms controlling cell-fate transitions, with metabolism emerging as a key regulator. Lactate-derived histone lactylation has recently been identified as an epigenetic modification regulating ...
Jorge Borbinha +6 more
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Non-histone lactylation in cancer: current advances and clinical implications [PDF]
Frontiers in ImmunologyLactylation, a novel post-translational modification characterized by the covalent attachment of lactate to specific lysine residues, has emerged as a critical metabolic regulator in cancer.
Robert Le Yang, Yiran Liang
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Histone lactylation-driven feedback loop modulates pyrimidine metabolism to promote oral carcinogenesis [PDF]
Cell Death and DiseaseMetabolic reprogramming and epigenetic alterations promote oral squamous cell carcinoma (OSCC). Lactate-dependent histone modification is a novel histone mark that connects the epigenetic process of lactylation to glycolytic metabolites.
Yanting Wang +8 more
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Metabolic regulation of gene expression by histone lactylation [PDF]
Nature, 2019 The Warburg effect, which originally described increased production of lactate in cancer, is associated with diverse cellular processes such as angiogenesis, hypoxia, polarization of macrophages and activation of T cells. This phenomenon is intimately linked to several diseases including neoplasia, sepsis and autoimmune diseases1,2.
Jun Ding, Sangkyu Lee
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Lactate-induced histone lactylation by p300 promotes osteoblast differentiation.
PLoS ONE, 2023 Lactate, which is synthesized as an end product by lactate dehydrogenase A (LDHA) from pyruvate during anaerobic glycolysis, has attracted attention for its energy metabolism and oxidant effects.
Erika Minami +7 more
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Biochemistry and regulation of histone lysine l-lactylation
Nature Reviews Molecular Cell BiologyHistone L-lactylation is a newly identified, metabolism-linked short-chain Lys acylation. Mounting evidence indicates that Lys L-lactylation has key roles in transcription regulation and many other cellular processes and is associated with diverse pathophysiological changes.
Philip Cole, Hening Lin, Xinlei Sheng
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