Results 1 to 10 of about 4,358 (213)

Mechanical Pressure, Histone Lactylation, And Salivary Gland Fibrosis

International Dental Journal
Aim or purpose: To investigate the link between mechanical pressure and histone lactylation in salivary gland fibrosis. Materials and methods: An animal model of salivary gland fibrosis was constructed by anatomically isolating and ligating the ...
Yubin Cao, Wang Guanru, Li Chunjie
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Microglia lactylation in relation to central nervous system diseases [PDF]

The development of neurodegenerative diseases is closely related to the disruption of central nervous system homeostasis. Microglia, as innate immune cells, play important roles in the maintenance of central nervous system homeostasis, injury response ...
Dong, Jianhong, Fan, Ziwei, Jia, Mengxian, Mo, Nan, Tong, Lily, Wang, Ying, Yang, Hui, Yue, Juanqing   +7 more
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Lactylation as a metabolic-epigenetic switch in cancer: dual roles in cell death resistance and therapeutic vulnerability

Cell Death and Disease
Protein lactylation emerges as a pivotal metabolic rheostat, translating microenvironmental lactate flux into stable programs that orchestrate cancer treatment resistance. This review synthesizes recent advances under the framework of “Lactylation Switch
Chengjiao Yang, Ruici Yang, Binbin Zheng, Hongxiao Jiang, Xianteng Wang, Weiren Huang   +5 more
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Lactylation in tumor: mechanisms and therapeutic potentials [PDF]

Lactate, a central product of glucose metabolism, plays a vital role in energy supply and signal transduction, and it also participates in gene transcription regulation through lactylation.
Dandan Wang, Hao Rong, Jun Peng, Ke Ma
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Gastrodin attenuates rheumatoid arthritis by targeting KAT8 to inhibit the lactylation of H3K9 [PDF]

Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by synovial inflammation and joint destruction, with limited therapeutic options.
Haiyan Chen, Huajiao Xu, Huajiao Xu, Huiming Yu, Huiming Yu, Jiaqin Wu, Jiaqin Wu, Jiayi Luo, Minfu Liu, Muhammad Farrukh Nisar, Qianqian Du, Qianqian Du, Shan Jiang, Shan Jiang, Shunshun Wang, Shunshun Wang, Shuwan Hou, Siyi Ye, Siyi Ye, Yufang Dai   +19 more
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Lactate metabolism and lactylation in cardiovascular disease: novel mechanisms and therapeutic targets [PDF]

Cardiovascular disease (CVD) is responsible for approximately 30% of annual global mortality rates, yet existing treatments for this condition are considered less than ideal. Despite being previously overlooked, lactate, a byproduct of glycolysis, is now
Cheng Zhou, Cheng Zhou, Han Zhang, Han Zhang, Jiahong Xia, Jiahong Xia, Jiahong Xia, Jie Wu, Jie Wu, Jie Wu, Jiulu Zhao, Jiulu Zhao, Jizhang Yu, Jizhang Yu, Junjie Zong, Junjie Zong, Kexiao Zheng, Kexiao Zheng, Longyong Lai, Longyong Lai, Pinyan Huang, Pinyan Huang, Ran Li, Ran Li, Shuan Ran, Shuan Ran, Song Wang, Song Wang, Weicong Ye, Weicong Ye, Xi Zhang, Xi Zhang, Xiaohan Li, Xiaohan Li, Yanglin Hao, Yanglin Hao, Yuan Li, Yuan Li, Yuan Li, Zilong Luo, Zilong Luo   +40 more
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Lactate and lactylation in liver diseases: energy metabolism, inflammatory immunity and tumor microenvironment [PDF]

Liver diseases pose a significant threat to human health. Lactate, a byproduct of glycolysis, serves various biological functions, including acting as an energy source, a signaling molecule, and a substrate for lactylation. Lactylation is a novel lactate-
Dingye Wang, Minlan Yang, Shiyi Cheng, Xiaoyu Xiao, Xiyuan Wang   +4 more
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Elevated Histone Lactylation Mediates Ferroptosis Resistance in Endometriosis Through the METTL3‐Regulated HIF1A/HMOX1 Signaling Pathway

Advanced Science
Endometriosis (EMs) is a chronic gynecologic condition characterized by the growth of endometrial stromal and glandular tissue outside the uterine cavity of unknown etiology.
Zongwen Liang, Jinming Liu, Yanling Gou, Honglin Wang, Zhi Li, Yingying Cao, Huiyan Zhang, Ruru Bai, Zongfeng Zhang   +8 more
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The lactylation-immunosuppression network in cancer: driving a metabolic-epigenetic axis

Frontiers in Immunology
The accumulation of lactate in the tumor microenvironment (TME), driven by the Warburg effect, is closely associated with immunosuppression. Lactate can contribute to this process through lysine lactylation, a novel post-translational modification.
Jinfeng Ye, Yunliang Lu, Wansu Huang, Shan Huang, Shan Huang, Zhe Zhang, Zhe Zhang, Xiaoying Zhou, Xiaoying Zhou, Xue Xiao, Tingting Huang   +10 more
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The effect of lactate dehydrogenase B and its mediated histone lactylation on chondrocyte ferroptosis during osteoarthritis

Journal of Orthopaedic Surgery and Research
Background Histone lactylation is a novel epigenetic regulator that is reported to participate in gene expression. Ferroptosis is an oxidative form of cell death and chondrocyte ferroptosis crucially impacts the development of osteoarthritis (OA).
Yang Zhang, Chen-Yu Zhao, Zheng Zhou, Cheng-Cun Li, Qiang Wang   +4 more
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