Results 31 to 40 of about 128,524 (232)

Lactate metabolic reprogramming and histone lactylation modification in sepsis [PDF]

International Journal of Biological Sciences
Sepsis, a serious condition characterized by life-threatening organ dysfunction owing to infection, lacks specific therapeutic interventions. Lactate serves as a crucial biomarker in sepsis, reflecting both the patient's metabolic state and the severity of the condition.
Zhang, Ji, Wu, Dan, Zeng, Fu, Gu, Haiyun, Li, Chengbao, Cata, Juan P, Guo, Kefang, Miao, Changhong, Zhang, Hao   +8 more
openaire   +4 more sources

Glycolysis‐Histone Lactylation Crosstalk Drives TXNIP‐NLRP3‐Mediated PANoptosome Assembly and PANoptosis Activation Underlying Diabetic Retinopathy Pathogenesis

MedComm
Diabetic retinopathy (DR), a major cause of vision loss in adults, involves aberrant metabolism and inflammation. This study investigated the interplay between glycolysis, histone lactylation, and PANoptosis in DR using human retinal pigment epithelial ...
Xiaoting Xi, Qianbo Chen, Jia Ma, Xuewei Wang, Yuxin Zhang, Qiuxia Xiong, Xiaolei Liu, Yuan Xia, Yan Li   +8 more
doaj   +2 more sources

Lactylation of histone by BRD4 regulates astrocyte polarization after experimental subarachnoid hemorrhage

Journal of Neuroinflammation
Under subarachnoid hemorrhage (SAH) conditions, astrocytes undergo a marked intensification of glycolytic activity, resulting in the generation of substantial amounts of lactate to maintain the energy demand for neurons and other brain cells. Lactate has
Fan Zhang, Jian Zhou, Peng Lu, Xianhui Zhang, Lei Yang, Jinpeng Wu, Lihan Zhang, Lifang Zhang, Jinwei Pang, Huangfan Xie, Bingqing Xie, Yong Jiang, Jianhua Peng   +12 more
doaj   +2 more sources

Histone Lactylation Is Involved in Mouse Oocyte Maturation and Embryo Development

International Journal of Molecular Sciences
Numerous post-translational modifications are involved in oocyte maturation and embryo development. Recently, lactylation has emerged as a novel epigenetic modification implicated in the regulation of diverse cellular processes. However, it remains unclear whether lactylation occurs during oocyte maturation and embryo development processes. Herein, the
Diqi Yang, Haoyi Zheng, Wenjie Lu, Xueqi Tian, Yanyu Sun, Hui Peng   +5 more
openaire   +3 more sources

Fusobacterium nucleatum promotes tumor progression driven by histone lactylation through increasing GLUT1 expression in colorectal cancer [PDF]

Journal of Translational Medicine
Background The gut microbiota plays a significant role in the incidence and progression of colorectal cancer（CRC）, with Fusobacterium nucleatum (F. nucleatum) identified as a contributor to the advancement of this malignancy.
Shizhen Zhou, Kai Wang, Hao Wang, Qinggang Yuan, Xinxin Yu, Lei Li, Linsen Shi, Qiongyuan Hu, Lixiang Liu, Chao Ding   +9 more
doaj   +2 more sources

Lactate metabolism and protein lactylation in programmed cell death: From novel mechanism to therapeutic strategies in human diseases

Clinical and Translational Medicine
Protein lactylation is a recently identified post‐translational modification that reflects cellular metabolic status. It plays an important role in regulating gene expression and maintaining essential cellular functions.
Yue Chen, Xiwen Wang, Xiuping Wang, Na Lin, Wenjie Wang, Ruiqi Fu, Yutong Wu, Yi Liu, Hengwei Liu   +8 more
doaj   +2 more sources

Histone and non-histone lactylation: molecular mechanisms, biological functions, diseases, and therapeutic targets

Molecular Biomedicine
Abstract Lysine lactylation (Kla) is a recently discovered post‑translational modification in which a lactyl moiety is transferred onto the ε‑amino group of lysine residues, linking cellular metabolism to epigenetic and signaling pathways. This process is regulated by a range of enzymes and metabolites, including lactate, “lactyltransferases (
Xia Peng, Juan Du
openaire   +4 more sources

The role and mechanism of histone lactylation in health and diseases

Frontiers in Genetics, 2022
Whether under anaerobic or aerobic conditions, glycolysis results in production of lactate. Increasing evidence suggests that lactate serves as a multifunctional signaling molecule that develops non-metabolic activities in addition to serving as a key metabolite to link glycolysis and oxidative phosphorylation.
Yumei Xie, Hongxia Hu, Maoting Liu, Tingting Zhou, Xi Cheng, Wei Huang, Ling Cao   +6 more
openaire   +3 more sources

DHX9 transcriptional upregulation and lactylation at K1024 fuels a glycolysis–histone lactylation loop in osteosarcoma [PDF]

Journal of Translational Medicine
Hao Wang, Zhongxuan Wu, Rui Yang, Shenglin Xu, Shunjie Yao, Ziheng Wu, Longze Xiao, Yukang Que, Peng He, Qiming Ma, Tangbing Xu, Wei Wei, Yong Hu   +12 more
openaire   +2 more sources

Hypoxic in vitro culture reduces histone lactylation and impairs pre-implantation embryonic development in mice

Epigenetics & Chromatin, 2021
Background Dynamic changes of histone posttranslational modifications are important contexts of epigenetic reprograming after fertilization in pre-implantation embryos.
Wanting Yang, Peijun Wang, Pengbo Cao, Shuang Wang, Yuxiao Yang, Huimin Su, Buhe Nashun   +6 more
doaj   +1 more source