Results 31 to 40 of about 4,358 (213)

Lactate-mediated histone lactylation promotes melanoma angiogenesis via IL-33/ST2 axis [PDF]

Cell Death and Disease
The pathogenesis of cancer is complicated, with metabolic reprogramming and angiogenesis as the hallmark characteristics. Recent reports have unveiled that the glycolytic metabolite lactate could modify histone lactylation to epigenetically regulate gene
Mao Zhao, Yuxuan Qian, Lin He, Taoxin Peng, Hanbin Wang, Xiangxu Wang, Linhan Jiang, Jinrong Fan, Hengxiang Zhang, Di Qu, Qing Zhu, Hao Wang, Shida Zhang, Chenyang Li, Xiwen Dong, Xianya Zhao, Huina Wang, Yuqi Yang, Xiuli Yi, Tao Zhao, Yu Liu, Jianglin Zhang, Guoqiang Zhang, Qiong Shi, Tianwen Gao, Chunying Li, Weinan Guo   +26 more
doaj   +2 more sources

H3K18 lactylation marks tissue-specific active enhancers [PDF]

, 2022
Background: Histone lactylation has been recently described as a novel histone post-translational modification linking cellular metabolism to epigenetic regulation.
Castellano-Castillo, Daniel, De Bock, Katrien, de Sousa, Joao Agostinho, Desgeorges, Thibaut, Engl, Magdalena, Galle, Eva, Ghosh, Adhideb, Hinte, Laura C, Melrose, Kate, Ruiz, Jonatan R, Ruiz-Ojeda, Francisco Javier, von Meyenn, Ferdinand, Wong, Chee-Wai   +12 more
core   +4 more sources

Role of Histone Lactylation in Neurological Disorders. [PDF]

Int J Mol Sci
Lactate is not only the end product of glycolysis but also plays a key role in epigenetic regulation. Recently, lactate-derived histone lactylation has been identified as a novel epigenetic modification that can directly influence gene transcription.
Zhang YM, Yang F, Li Q, Zhang JN.
europepmc   +3 more sources

Histone lactylation: epigenetic mark of glycolytic switch

Trends in Genetics, 2022
Histone lactylation and acetylation compete for epigenetic modification of lysines and mark the levels of lactates and acetyl-CoA. Whether pyruvate is committed to lactate or acetyl-CoA generation as the outlet of glycolysis determines cell fate towards malignancy or not. Taking control over the glycolytic switch as marked by lactylation suggests novel
Dai, Xiaofeng, Lv, Xinyu, Thompson, Erik W, Ostrikov, Kostya Ken   +3 more
openaire   +3 more sources

Resistance training in humans and mechanical overload in rodents do not elevate muscle protein lactylation [PDF]

, 2023
Although several reports have hypothesized that exercise may increase skeletal muscle protein lactylation, empirical evidence in humans is lacking.
Anglin, Derick A., Fei, Shengyi, Godwin, Joshua S., Kontos, Nicholas J., Mattingly, Madison L., McIntosh, Mason C., Michel, J. Max, Mobley, C. Brooks, Phillips, Stuart M., Plotkin, Daniel L., Roberts, Michael D., Ruple, Auburn University A., Sexton, Casey L., Smith, Morgan A., Vann, Christopher G., Vechetti, Ivan Jose, Jr   +15 more
core   +5 more sources

Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis. [PDF]

, 2020
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability.
Coras, Roxana, Guma, Monica, Murillo-Saich, Jessica D   +2 more
core   +2 more sources

Role of D(-)-Lactic Acid in Prevention of Chlamydia trachomatis Infection in an In Vitro Model of HeLa Cells [PDF]

, 2023
A vaginal microbiota dominated by certain Lactobacillus species may have a protective effect against Chlamydia trachomatis infection. One of the key antimicrobial compounds produced is lactic acid, which is believed to play a central role in host defense.
Calonghi, Natalia, Djusse, Marielle Ezekielle, Fato, Romana, Foschi, Claudio, Marangoni, Antonella, Marziali, Giacomo, Morselli, Sara, Naldi, Marina, Rizzardi, Nicola, Zalambani, Chiara   +9 more
core   +1 more source

Hypoxic in vitro culture reduces histone lactylation and impairs pre-implantation embryonic development in mice

Epigenetics & Chromatin, 2021
Background Dynamic changes of histone posttranslational modifications are important contexts of epigenetic reprograming after fertilization in pre-implantation embryos.
Wanting Yang, Peijun Wang, Pengbo Cao, Shuang Wang, Yuxiao Yang, Huimin Su, Buhe Nashun   +6 more
doaj   +1 more source

The Metabolic-Epigenetic Nexus in Type 2 Diabetes Mellitus [PDF]

, 2021
The prevalence of type 2 diabetes mellitus (T2DM) continues to rise globally. Yet the aetiology and pathophysiology of this noncommunicable, polygenic disease, is poorly understood.
Davison, Gareth, Irwin, Rachelle E, Walsh, CP   +2 more
core   +2 more sources

Lactate Promotes Macrophage HMGB1 Lactylation, Acetylation, and Exosomal Release in Polymicrobial Sepsis [PDF]

, 2021
High circulating levels of lactate and high mobility group box-1 (HMGB1) are associated with the severity and mortality of sepsis. However, it is unclear whether lactate could promote HMGB1 release during sepsis.
Fan, Min, Gill, P. S., Ha, Tuanzhu, Li, Chuanfu, Liu, Li, Tu, Fei, Wang, Xiaohui, Wang, Yana, Williams, David L., Xu, Jingjing, Yang, Kun   +10 more
core   +2 more sources