Results 21 to 30 of about 4,116 (175)

Lactate-mediated histone lactylation promotes melanoma angiogenesis via IL-33/ST2 axis [PDF]

Cell Death and Disease
The pathogenesis of cancer is complicated, with metabolic reprogramming and angiogenesis as the hallmark characteristics. Recent reports have unveiled that the glycolytic metabolite lactate could modify histone lactylation to epigenetically regulate gene
Mao Zhao, Yuxuan Qian, Lin He, Taoxin Peng, Hanbin Wang, Xiangxu Wang, Linhan Jiang, Jinrong Fan, Hengxiang Zhang, Di Qu, Qing Zhu, Hao Wang, Shida Zhang, Chenyang Li, Xiwen Dong, Xianya Zhao, Huina Wang, Yuqi Yang, Xiuli Yi, Tao Zhao, Yu Liu, Jianglin Zhang, Guoqiang Zhang, Qiong Shi, Tianwen Gao, Chunying Li, Weinan Guo   +26 more
doaj   +2 more sources

Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma

Genome Biology, 2021
Background Histone lactylation, a metabolic stress-related histone modification, plays an important role in the regulation of gene expression during M1 macrophage polarization.
Jie Yu, Peiwei Chai, Minyue Xie, Shengfang Ge, Jing Ruan, Xianqun Fan, Renbing Jia   +6 more
doaj   +1 more source

The role and mechanism of histone lactylation in health and diseases

Frontiers in Genetics, 2022
Whether under anaerobic or aerobic conditions, glycolysis results in production of lactate. Increasing evidence suggests that lactate serves as a multifunctional signaling molecule that develops non-metabolic activities in addition to serving as a key metabolite to link glycolysis and oxidative phosphorylation.
Yumei Xie, Hongxia Hu, Maoting Liu, Tingting Zhou, Xi Cheng, Wei Huang, Ling Cao   +6 more
openaire   +3 more sources

Histone lactylation: epigenetic mark of glycolytic switch

Trends in Genetics, 2022
Histone lactylation and acetylation compete for epigenetic modification of lysines and mark the levels of lactates and acetyl-CoA. Whether pyruvate is committed to lactate or acetyl-CoA generation as the outlet of glycolysis determines cell fate towards malignancy or not. Taking control over the glycolytic switch as marked by lactylation suggests novel
Dai, Xiaofeng, Lv, Xinyu, Thompson, Erik W, Ostrikov, Kostya Ken   +3 more
openaire   +3 more sources

Hypoxic in vitro culture reduces histone lactylation and impairs pre-implantation embryonic development in mice

Epigenetics & Chromatin, 2021
Background Dynamic changes of histone posttranslational modifications are important contexts of epigenetic reprograming after fertilization in pre-implantation embryos.
Wanting Yang, Peijun Wang, Pengbo Cao, Shuang Wang, Yuxiao Yang, Huimin Su, Buhe Nashun   +6 more
doaj   +1 more source

Research progress and prospect of histone lactylation in digestive system tumors [PDF]

Zhongguo aizheng zazhi
Histone lactylation is a novel type of post-translational modification, where a lactate molecule covalently binds to the lysine residues of histones. This modification plays a key role in cellular metabolic reprogramming, particularly in digestive system
ZENG Dandan, LUO Wenfeng, YE Jiazhou, LIN Yan, LIANG Rong
doaj   +3 more sources

Emerging role of histone and non-histone lactylation in metabolic reprogramming of female-specific malignancies. [PDF]

World J Surg Oncol
Sun C, Hu D, Peng W, Cui Z, Lin Y.
europepmc   +4 more sources

The Role of Histone Lactylation in Diseases and Intervention by Traditional Chinese Medicine

Shengwu huaxue yu shengwu wuli jinzhan
Histone lactylation is a recently identified post-translational modification, wherein lactate mediates the enzymatic addition of lactyl groups to lysine residues on histones.
ZHANG Xin, DU Jie, LI Zhao-Huan, GAO Feng   +3 more
doaj   +1 more source

Re-evaluating the mechanism of histone lactylation

, 2020
Recent work by Zhang et al. published in Nature identified a unique non-metabolic role of the glycolysis end-product lactate, in post-translational lactylation of histones. The original study as well as follow-up editorials allude that lactate after being activated as lactyl-CoA mediates histone lactylation.
Sunada Khadka, Yasaman Barekatain, Florian Muller   +2 more
openaire   +2 more sources

Histone lactylation links metabolism and gene regulation [PDF]

Nature, 2019
Cells regulate gene expression in part through the chemical labelling of histone proteins. Discovery of a label derived from lactate molecules reveals a way in which cells link gene expression to nutrient metabolism. Lactylation is a newly discovered epigenetic modification.
Luke T. Izzo, Kathryn E. Wellen
openaire   +1 more source