Results 21 to 30 of about 128,524 (232)

Histone H3 lysine 18 lactylation attenuates neuroinflammation and neurological damage by regulating microglial plxnb2 after ischemic stroke

Neurobiology of Disease
Microglia are major resident immune cells in the central nervous system and are actively involved in the pathogenesis of ischemic stroke. Histone lactylation confers macrophage homeostatic gene expressions and regulates physiological and immune-related ...
Ping Li, Yao Wang, Yuan Xu, Linyu Feng, Na Jiang, Yongkang Fang, Guini Song, Lingling Yu, Li Xu, Zhou Zhu, Suiqiang Zhu, Wei Wang, Minjie Xie   +12 more
doaj   +2 more sources

Histone lactylation maintains bovine early embryo development via regulating embryonic genome activation [PDF]

Journal of Animal Science and Biotechnology
Background Early embryo loss is an important factor affecting the reproductive capacity of cattle. Recent studies have revealed that during the process of embryonic genome activation (EGA), epigenetic modification, such as histone lactylation remodeling,
Wenjie Yu, Yi Xia, Wenzhuo Wang, Zhiyuan Yang, Zhengqiu Liu, Xinqi Gan, Mengya Zhang, Beibei Zhou, Yunsheng Li, Yunhai Zhang, Zubing Cao   +10 more
doaj   +2 more sources

Histone lactylation-driven feedback loop modulates pyrimidine metabolism to promote oral carcinogenesis [PDF]

Cell Death and Disease
Metabolic reprogramming and epigenetic alterations promote oral squamous cell carcinoma (OSCC). Lactate-dependent histone modification is a novel histone mark that connects the epigenetic process of lactylation to glycolytic metabolites.
Yanting Wang, Yanlin Geng, Yannan Chen, Haowen Zhang, Jingyu Liu, Yulin Song, Gang Wu, Tim Forouzanfar, Yuan Fan   +8 more
doaj   +2 more sources

Rhaponticin Blocks Glycolysis-Mediated Histone Lactylation to Suppress Tongue Squamous Cell Carcinoma via HIF-1α Activity Inhibition. [PDF]

Kaohsiung J Med Sci
ABSTRACT Tongue squamous cell carcinoma (TSCC) often develops therapeutic resistance. Metabolic reprogramming, particularly the glycolysis/lactate/histone lactylation axis, is a critical driver of tumor progression and therapy resistance. This study investigated the anti‐tumor mechanism of Rhaponticin (Rha), focusing on the metabolic/epigenetic axis ...
Wu Y, Yao LL, Jiang L, Fang ZY, Zhu JJ, Shao YS, Wang WJ, Wan XW.   +7 more
europepmc   +2 more sources

Histone lactylation enhances GCLC expression and thus promotes chemoresistance of colorectal cancer stem cells through inhibiting ferroptosis

Cell Death and Disease
Colorectal cancer stem cells (CCSCs) play a critical role in mediating chemoresistance. Lactylation is a post-translational modification induced by lactate that regulates gene expression.
Jiao Deng, Yangkun Li, Lanlan Yin, Shuang Liu, Yanqi Li, Wancheng Liao, Lei Mu, Xuelai Luo, Jichao Qin   +8 more
doaj   +2 more sources

Histone Lactylation Participates in Psoriasis Progression by Regulating the Adiponectin Expression

Clinical, Cosmetic and Investigational Dermatology
Psoriasis is a chronic inflammatory skin disease characterized by erythema, papules, and plaques. Adiponectin (ADIPOQ) is an important protein hormone secreted by adipose tissue. Here, we aimed to explore the expression of ADIPOQ in psoriasis patients and the moderation effect of histone lactylation on ADIPOQ.The GSE78097 data set was downloaded from ...
Zhao,Sicheng, Wu,Tingyan, Fu,Mingjing, Zhang,Zhe   +3 more
openaire   +5 more sources

Histone lactylation: a novel epigenetic bridge linking cellular metabolism to benign and malignant gynecological diseases [PDF]

Clinical Epigenetics
Lactic acid modification of histones represents an emerging post-translational modification that establishes a critical link between cellular metabolic reprogramming and epigenetic regulation through the covalent binding of lactic acid to histone lysine ...
Wanhui You, Siyu Wang, Yue Zhang, Xin Su, Fangyuan Liu, Danni Ding, Fengjuan Han, Ying Guo   +7 more
doaj   +2 more sources

Lactylation: From Molecular Insights to Disease Relevance

Biomolecules
Lactylation, referring to the covalent coupling of the lactyl group with lysine residues, is a recently defined post-translational modification. It has been demonstrated that lactylation can alter protein transcription, thereby affecting the transmission
Yao Xu, Lu Zhang, Dong Shang, Hong Xiang
doaj   +2 more sources

Therapeutic potential of microglial SMEK1 in regulating H3K9 lactylation in cerebral ischemia-reperfusion

Communications Biology
Acute ischemic stroke (AIS) triggers immune responses and neuroinflammation, contributing to brain injury. Histone lactylation, a metabolic stress-related histone modification, plays a critical role in various diseases, but its involvement in cerebral ...
Wei-Yue Si, Chun-Lin Yang, Shu-Li Wei, Tong Du, Liang-Kang Li, Jing Dong, Yang Zhou, Heng Li, Peng Zhang, Qi-Ji Liu, Rui-Sheng Duan, Ruo-Nan Duan   +11 more
doaj   +2 more sources

Histone lactylation-related genes correlate with the molecular patterns and functions of cancer-associated fibroblasts and have significant clinical implications in clear cell renal cell carcinoma

Heliyon
Recent research emphasised the indispensable role of histone lactylation in the activation of hepatic stellate cells. The VHL mutation is extremely common in clear cell renal cell carcinoma, which normally causes a metabolic shift in cancer cells and ...
Weiyu Kong, Jiaxin He, Qinyao Zhou, Xin Zhou, Xiyi Wei, Yonglin Yang, Yiwen Mei, Shuai Wang, Xi Zhang, Bing Yao, Yulin Yue, Jiali Xu, Minjun Jiang, Chen Xu   +13 more
doaj   +2 more sources