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Histone Lactylation in Diseases: Regulation by Traditional Chinese Medicine and Therapeutic Implications [PDF]

Drug Design, Development and Therapy
Yuyue Qiu, Xiaoni Shao College of Pharmacy and Food, Southwest Minzu University, Chengdu, Sichuan, 610225, People’s Republic of ChinaCorrespondence: Xiaoni Shao, College of Pharmacy and Food, Southwest Minzu University, #168 Dajian Street ...
Qiu Y, Shao X
doaj   +2 more sources

Histone Lactylation Antagonizes Senescence and Skeletal Muscle Aging by Modulating Aging‐Related Pathways [PDF]

Advanced Science
Epigenetic alterations are among the prominent drivers of cellular senescence and/or aging, intricately orchestrating gene expression programs during these processes.
Fanju Meng, Jianuo He, Xuebin Zhang, Wencong Lyu, Ran Wei, Shiyi Wang, Zhehao Du, Haochen Wang, Jinlong Bi, Xueyang Hua, Chao Zhang, Yiting Guan, Guoliang Lyu, Xiao‐Li Tian, Lijun Zhang, Wenbing Xie, Wei Tao   +16 more
doaj   +2 more sources

Non-histone lactylation: unveiling its functional significance [PDF]

Frontiers in Cell and Developmental Biology
Lactylation, a newly discovered protein posttranslational modification (PTM) in 2019, primarily occurs on lysine residues. Lactylation of histones was initially identified, and subsequent studies have increasingly demonstrated its widespread presence on ...
Pusong Shi, Shaolu Zhang, Shaolu Zhang, Shaolu Zhang, Shaolu Zhang, Shaolu Zhang, Yongjie Ma, Yongjie Ma, Yongjie Ma, Yongjie Ma, Yongjie Ma   +10 more
core   +4 more sources

Histone H3K18 and Ezrin Lactylation Promote Renal Dysfunction in Sepsis‐Associated Acute Kidney Injury

Advanced Science
Histone lactylation is a metabolic stress‐related histone modification. However, the role of histone lactylation in the development of sepsis‐associated acute kidney injury (SA‐AKI) remains unclear.
Jiao Qiao, Yuan Tan, Hongchao Liu, Boxin Yang, Qian Zhang, Qi Liu, Wenyuan Sun, Zhongxin Li, Qingchen Wang, Weimin Feng, Shuo Yang, Liyan Cui   +11 more
doaj   +2 more sources

Positive feedback regulation between glycolysis and histone lactylation drives oncogenesis in pancreatic ductal adenocarcinoma

Molecular Cancer
Background Metabolic reprogramming and epigenetic alterations contribute to the aggressiveness of pancreatic ductal adenocarcinoma (PDAC). Lactate-dependent histone modification is a new type of histone mark, which links glycolysis metabolite to the ...
Fei Li, Wenzhe Si, Li Xia, Deshan Yin, Tianjiao Wei, Ming Tao, Xiaona Cui, Jin Yang, Tianpei Hong, Rui Wei   +9 more
doaj   +2 more sources

Lactate and lysine lactylation of histone regulate transcription in cancer

Heliyon
Histone lysine modifications were well-established epigenetic markers, with many types identified and extensively studied. The discovery of histone lysine lactylation had revealed a new form of epigenetic modification.
Yunhao Yang, Nanzhi Luo, Zhipeng Gong, Wenjing Zhou, Yin Ku, Yaohui Chen   +5 more
doaj   +3 more sources

Women with polycystic ovary syndrome exhibit impaired endometrial receptivity with excessive ERα and histone lactylation [PDF]

Nature Communications
Polycystic ovary syndrome (PCOS) is one of the most common reproductive disorders in women and severely impairs fertility. Extant clinical studies can only provide indirect and plausible evidence to support endometrial dysfunction as an ovary-independent
Hongying Shan, Yue Wang, Baoying Liao, Kai-Lun Hu, Xiunan Chen, Chenxi Xiao, Zi Yang, Fenting Liu, Tianliu Peng, Mingmei Lin, Feng Deng, Ping Zhou, Yang Yu, Rong Li, Heng Pan   +14 more
doaj   +2 more sources

From metabolic reprogramming to epigenetic modification: association network and targeted treatment strategy between histone lactylation and tumor progression [PDF]

Frontiers in Immunology
Metabolic reprogramming and epigenetic modification have been widely observed in cancer research. Based on accumulating experimental evidence in recent years, beginning with metabolic reprogramming driven by carcinogenic signals, the accumulation of key ...
Yi Li, Lu Feng, Qian Shen, Xiaochen Jiang, Fudong Liu, Chuanlong Zhang, Runzhi Qi, Bo Pang, Bo Pang   +8 more
doaj   +2 more sources

DPF2 reads histone lactylation to drive transcription and tumorigenesis

Proceedings of the National Academy of Sciences of the United States of America
Lysine lactylation (Kla) is a new type of histone mark implicated in the regulation of various functional processes such as transcription. However, how this histone mark acts in cancers remains unexplored due in part to a lack of knowledge about its reader proteins.
Guijin Zhai, Kai Zhang
exaly   +3 more sources

Lysine lactylation in diseases: beyond histone lactylation. [PDF]

Cell Death Dis
Abstract Lactylation, a recently identified post-translational modification, was initially characterized as lysine residue modification in histone subunits that regulates gene transcription via epigenetic mechanisms. Elevated intracellular lactate has been shown to drive histone lysine lactylation (Kla), establishing its association ...
Liu Y, Guo X, Hu X, Zhou S, Yang Q, Feng P, Zeng L.   +6 more
europepmc   +2 more sources