Is Lactate an Oncometabolite? Evidence Supporting a Role for Lactate in the Regulation of Transcriptional Activity of Cancer-Related Genes in MCF7 Breast Cancer Cells. [PDF]
, 2019 Lactate is a ubiquitous molecule in cancer. In this exploratory study, our aim was to test the hypothesis that lactate could function as an oncometabolite by evaluating whether lactate exposure modifies the expression of oncogenes, or genes encoding ...
Brooks, George A +4 more
core +1 more source
Histone lactylation links metabolism and gene regulation [PDF]
Nature, 2019 Cells regulate gene expression in part through the chemical labelling of histone proteins. Discovery of a label derived from lactate molecules reveals a way in which cells link gene expression to nutrient metabolism. Lactylation is a newly discovered epigenetic modification.
Luke T. Izzo, Kathryn E. Wellen
openaire +1 more source
Impact of Physical Activity and Exercise on the Epigenome in Skeletal Muscle and Effects on Systemic Metabolism [PDF]
, 2022 Julio Plaza-Diaz and Concepcion M. Aguilera are part of the "UGR Plan Propio de Investigacion 2016" and the "Excellence actions: Unit of Excellence on Exercise and Health (UCEES), University of Granada".
Aguilera, Concepción M. +5 more
core +1 more source
Trained immunity in diabetes and hyperlipidemia: Emerging opportunities to target cardiovascular complications and design new therapies [PDF]
, 2023 Some metabolic diseases, such as diabetes and hyperlipidemia, are associated with a state of inflammation, which adversely affects cardiovascular health.
Akbar, Naveed +3 more
core +2 more sources
Correction: Non-histone lactylation: unveiling its functional significance. [PDF]
Front Cell Dev BiolShi P, Ma Y, Zhang S.
europepmc +3 more sources
The expanding constellation of histone post-translational modifications in the epigenetic landscape [PDF]
, 2021 The emergence of a nucleosome-based chromatin structure accompanied the evolutionary transition from prokaryotes to eukaryotes. In this scenario, histones became the heart of the complex and precisely timed coordination between chromatin architecture and
Cavalieri V.
core +1 more source
Lactate Suppresses Immunometabolic and Inflammatory Responses in Monocytes [PDF]
, 2022 Many diseases are preventable through regular exercise. However, high-intensity exercise can transiently suppress immune function. Lactate can decrease inflammatory responses through epigenetic modifications such as histone lactylation, inhibiting ...
Davis, Kierstin Lynn
core +1 more source
Integration of transcriptional and metabolic control in macrophage activation [PDF]
, 2021 Macrophages react to microbial and endogenous danger signals by activating a broad panel of effector and homeostatic responses. Such responses entail rapid and stimulus-specific changes in gene expression programs accompanied by extensive rewiring of ...
Ghisletti S +3 more
core +1 more source
Class I histone deacetylases catalyze lysine lactylation
Journal of Biological ChemistryAbstractMetabolism and post-translational modifications (PTMs) are intrinsically linked and the number of identified metabolites that can covalently modify proteins continues to increase. This metabolism/PTM crosstalk is especially true for lactate, the product of anaerobic metabolism following glycolysis.
Takeshi Tsusaka +7 more
openaire +3 more sources
Re-evaluating the mechanism of histone lactylation
, 2020 Recent work by Zhang et al. published in Nature identified a unique non-metabolic role of the glycolysis end-product lactate, in post-translational lactylation of histones. The original study as well as follow-up editorials allude that lactate after being activated as lactyl-CoA mediates histone lactylation.
Sunada Khadka +2 more
openaire +2 more sources