Results 51 to 60 of about 4,116 (175)

Lysine lactylation regulates ATF4-mediated stress responses under glucose starvation in canine hemangiosarcoma

Frontiers in Veterinary Science
Excess lactate is produced in tumor cells by aerobic glycolysis and regulates gene expressions by histone lactylation. However, how histone lactylation functions under glucose-limited conditions remains unknown.
Tamami Suzuki, Kazuki Heishima, Kazuki Heishima, Kazuki Heishima, Jumpei Yamazaki, Jumpei Yamazaki, Masaya Yamazaki, Ryohei Kinoshita, Ryohei Kinoshita, Sangho Kim, Sangho Kim, Sangho Kim, Kenji Hosoya, Kenji Hosoya, Kenji Hosoya, Yuko Okamatsu-Ogura, Michihito Sasaki, Peng Xu, Qin Yan, Takashi Kimura, Keisuke Aoshima, Keisuke Aoshima   +21 more
doaj   +1 more source

Lactate and lactylation: molecular insights into histone and non-histone lactylation in tumor progression, tumor immune microenvironment, and therapeutic strategies

Biomarker Research
Abstract Investigating cancer metabolism is of paramount importance for understanding tumor biology and developing novel therapeutic strategies. Lactylation, a posttranslational modification facilitated by the glycolytic product lactate, plays a crucial role in regulating oncogenic signalling pathways.
Xiao, Shuying, Zhang, Suhang, Sun, Kai, Huang, Qibo, Li, Qilin, Hu, Chuanyu   +5 more
openaire   +2 more sources

Reversing brain aging: Targeting energy metabolism in endogenous neural stem cells

Interdisciplinary Medicine, EarlyView.
Mechanism of endogenous neural stem cells (eNSCs) energy metabolism disorder leading to brain aging and targeted eNSCs intervention strategies (By biorender). The disorder of energy metabolism of eNSCs can lead to their resting and aging, and eventually lead to brain aging.
Chong Chen, Jiayi Wang, Jimin Yu, Yiran Zhou, Lihai Liu, Jing Liu, Liang Wang   +6 more
wiley   +1 more source

H4K79 and H4K91 histone lactylation, newly identified lactylation sites enriched in breast cancer

Journal of Experimental & Clinical Cancer Research
Abstract Metabolic reprogramming and epigenetic modification are two hallmarks of cancer. Protein lysine lactylation (Kla) is a novel type of glycolysis lactate-triggered posttranslational modification. However, the role of Kla in breast cancer (BC) remains largely unknown.
Liu, Jiena, Zhao, Liuying, Yan, Meisi, Jin, Shengye, Shang, Lingmin, Wang, Jianyu, Wang, Qin, Zhao, Shilu, Shen, Zibo, Liu, Tong, Wu, Hao, Pang, Da   +11 more
openaire   +2 more sources

KAT2A Promotes the Progression of Renal Cell Carcinoma by Regulating the Succinylation of SERPINE2

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Epithelial‐mesenchymal transition (EMT) and angiogenesis are critical drivers of renal cell carcinoma (RCC) progression, yet their upstream regulatory mechanisms remain incompletely understood. This study aimed to investigate the role of KAT2A in RCC and elucidate the underlying molecular mechanism by which it promotes tumor progression.
Chang‐Cheng Liu, Xue‐Dong Li
wiley   +1 more source

Rhaponticin Blocks Glycolysis‐Mediated Histone Lactylation to Suppress Tongue Squamous Cell Carcinoma via HIF‐1α Activity Inhibition

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Tongue squamous cell carcinoma (TSCC) often develops therapeutic resistance. Metabolic reprogramming, particularly the glycolysis/lactate/histone lactylation axis, is a critical driver of tumor progression and therapy resistance. This study investigated the anti‐tumor mechanism of Rhaponticin (Rha), focusing on the metabolic/epigenetic axis ...
Yuan Wu, Liang‐Liang Yao, Lin Jiang, Zhi‐Yi Fang, Jia‐Jun Zhu, Yi‐Sen Shao, Wen‐Juan Wang, Xiao‐Wen Wan   +7 more
wiley   +1 more source

Recent Advances in Top‐Down Proteomics for Single‐Cell Research

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Individual cells have distinctive molecular characteristics, including biologically relevant proteoforms. Although single‐cell (SC) molecular omics offer unprecedented insights into cellular heterogeneity and function, the characterization of proteoforms in SCs remains an uncharted territory.
Jake A. Melby, Pei Su, Fabio P. Gomes
wiley   +1 more source

tRNA‐Derived Small RNAs in Digestive Cancers: From Translational Regulation to Immune and Extracellular Communication

Cancer Science, EarlyView.
tRNA‐derived small RNAs (tsRNAs) function in digestive cancers across three scales: intracellular translational and metabolic control, extracellular vesicle–mediated immune remodeling, and systemic and host–microbe communication. This review organizes these mechanisms by evidence strength, from well‐established intracellular roles to emerging ...
Wang Xitan, Li Han
wiley   +1 more source

Glycolysis-mediated H3K18la modifications drive aggressive bladder cancer through metabolic and epigenetic reprogramming

Frontiers in Immunology
BackgroundMetabolic reprogramming and epigenetic alterations contribute to the aggressiveness of human bladder cancer (BC). Lactate-dependent histone modification represents a novel class of histone marks that links the glycolytic metabolite to the ...
Zhan Wang, Zhan Wang, Zhaokai Zhou, Zhaokai Zhou, Shuai Yang, Zihao Zhao, Xiaozu Li, Xingchen Liu, Guangyang Cheng, Guangyang Cheng, Ran Xu, Ran Xu, Qi Li, Dong Xing   +13 more
doaj   +1 more source

Histone lactylation as a driver of metabolic reprogramming and immune evasion

Medical Review
Abstract Lactate is the end product of glycolysis, and extensive research has shown that lactate participates in various pathophysiological processes. Along with associated hydrogen ions, lactate typically functions as an immunosuppressive negative factor and plays a crucial role in tumor metabolic reprogramming.
Qiaoting Cai, Wei Deng, Yutian Zou, Zhe-Sheng Chen, Hailin Tang   +4 more
openaire   +3 more sources