Results 51 to 60 of about 128,524 (232)

Histone lactylation promotes rheumatoid arthritis progression by increasing NFATc2 expression and the production of anti-lactylated histone autoantibodies

Nature Communications
Elevated lactate in the joint microenvironment of rheumatoid arthritis patients is crucial for disease progression, though the mechanism remains unclear. This study shows significantly increased global lactylation levels within fibroblast-like synoviocytes from RA patients compared to healthy controls, with lactylated proteins being enriched in ...
Gan Wu, Chenglin Yang, Yuan Huang, Bin Liu, Haige Zhai, Zelin Cao, Siyue Lu, Jijian Ji, Xinyue Yin, Xianming Xin, Shengwei Jin, Youzhi Cai, Jianguang Wang   +12 more
openaire   +2 more sources

H3K18 lactylation promotes allergic airway inflammation in asthma via a CSF1/CSF1R/MAPK autocrine axis

Respiratory Research
Background Metabolic reprogramming of airway epithelial cells is a hallmark of asthma, yet the mechanisms by which altered metabolism drives inflammation remain largely unknown.
Minxuan Hu, Yixin Chen, Haohua Huang, Jinzhong Zhuo, Haishan Zhong, Dongyu Liu, Qi Yu, Yuhan Du, Jinming Zhang, Shaoxi Cai, Hangming Dong   +10 more
doaj   +1 more source

Histone lactylation regulates cancer progression by reshaping the tumor microenvironment

Frontiers in Immunology, 2023
As a major product of glycolysis and a vital signaling molecule, many studies have reported the key role of lactate in tumor progression and cell fate determination. Lactylation is a newly discovered post-translational modification induced by lactate. On the one hand, lactylation introduced a new era of lactate metabolism in the tumor microenvironment (
Junxing Qu, Peizhi Li, Zhiheng Sun
openaire   +3 more sources

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

Tumor-derived lactate promotes resistance to bevacizumab treatment by facilitating autophagy enhancer protein RUBCNL expression through histone H3 lysine 18 lactylation (H3K18la) in colorectal cancer

, 2023
Bevacizumab plays an important role in the first and second line treatment for metastatic colorectal cancer (CRC). And induction of hypoxia and the tumors response to it plays an important role in determining the efficacy of antiangiogenic therapy while ...
Jianhong Peng (3995585), Yanbo Xu (8399277), Chi Zhou (400602), Long Yu (212089), Qingjian Ou (3809311), Jiahua He (10649933), Zhenhai Lu (2711992), Huashan Liu (4401871), Lingheng Kong (1391968), Yujing Fang (381201), Jin Lan (450306), Weihao Li (2390917), Zhenlin Hou (6080801), Xiaojun Wu (466801), Zhizhong Pan (381203), Junzhong Lin (4866808)   +15 more
core   +1 more source

DLST Succinylation‐Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma

Advanced Science, EarlyView.
The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Xuanxuan Li, Peijun Zhou, Xingzhi Peng, Qixin Liu, Wenhui Zeng, Rui Wang, Liangfang Shen, Jinwu Peng, Qin Zhou, Lifang Yang   +9 more
wiley   +1 more source

Class I histone deacetylases catalyze lysine lactylation

Journal of Biological Chemistry
Abstract Metabolism and post-translational modifications (PTMs) are intrinsically linked and the number of identified metabolites that can covalently modify proteins continues to increase. This metabolism/PTM crosstalk is especially true for lactate, the product of anaerobic metabolism following glycolysis.
Takeshi Tsusaka, Mohd. Altaf Najar, Isha Sharma, Mariola M. Marcinkiewicz, Claudia Veronica Da Silva Crispim, Nathaniel W. Snyder, George M. Burslem, Emily L. Goldberg   +7 more
openaire   +4 more sources

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

Both L-lactyl and D-lactyl enantiomers modify histones in mouse testis

Molecular & Cellular Proteomics
Abstract Dynamic histone post-translational modifications are crucial to precisely orchestrate gene expression programs. The recently discovered histone lysine lactylation has already been explored in various pathological contexts, but less in normal tissues.
Manessier, Julie, Hijazi, Hassan, Brugière, Sabine, Courçon, Marie, Masselon, Christophe, de la Iglesia, Alberto, Cocquet, Julie, Pflieger, Delphine   +7 more
openaire   +3 more sources

Histone Lactylation.

These are raw data for histone lactylation.
Xiaoyu Zhang (17790308)
core   +1 more source