Results 1 to 10 of about 721,178 (311)

Lactate: A key regulator of the immune response

Immunity
Lactate, the end product of both anaerobic and aerobic glycolysis in proliferating and growing cells-with the latter process known as the Warburg effect-is historically considered a mere waste product of cell and tissue metabolism. However, research over
Claudio Mauro, Michelangelo Certo, Alba Llibre   +2 more
exaly   +2 more sources

Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization

Cell Metabolism, 2020
Summary Endothelial cell (EC)-derived signals contribute to organ regeneration, but angiocrine metabolic communication is not described. We found that EC-specific loss of the glycolytic regulator pfkfb3 reduced ischemic hindlimb revascularization and ...
Andrea Banfi, Sarah-Maria Fendt, Melanie Planque   +2 more
exaly   +2 more sources

Lactate Metabolism in Human Lung Tumors

Cell, 2017
Summary Cancer cells consume glucose and secrete lactate in culture. It is unknown whether lactate contributes to energy metabolism in living tumors.
Craig Malloy, Kemp Kernstine, JOSÉ Torrealba   +2 more
exaly   +2 more sources

Role of Lactate in Inflammatory Processes: Friend or Foe

Frontiers in Immunology, 2022
During an inflammatory process, shift in the cellular metabolism associated with an increase in extracellular acidification are well-known features. This pH drop in the inflamed tissue is largely attributed to the presence of lactate by an increase in ...
Carolina Manosalva, John Quiroga, John Quiroga, Alejandra I. Hidalgo, Pablo Alarcón, Nicolás Ansoleaga, Nicolás Ansoleaga, María Angélica Hidalgo, Rafael Agustín Burgos   +8 more
doaj   +2 more sources

Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS

Cell, 2019
SUMMARY RLR-mediated Type-I IFN production plays a pivotal role in elevating host immunity for viral clearance and cancer immune-surveillance. Here we report that glycolysis, which is inactivated during RLR activation, serves as a barrier to impede type ...
Guihua Wang, Bo-Syong Pan, Hong-Yu Li
exaly   +2 more sources

Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring

Cell Metabolism, 2019
Summary Accumulation of lactate in the tissue microenvironment is a feature of both inflammatory disease and cancer. Here, we assess the response of immune cells to lactate in the context of chronic inflammation.
Joanne Mccorriston, Myles J Lewis, Massimiliano Ruscica   +2 more
exaly   +2 more sources

Lactate metabolism in human health and disease

Signal Transduction and Targeted Therapy, 2022
The current understanding of lactate extends from its origins as a byproduct of glycolysis to its role in tumor metabolism, as identified by studies on the Warburg effect.
Xiaolu Li, Yanyan Yang, Bei Zhang, Xiaotong Lin, Xiuxiu Fu, Yi An, Yulin Zou, Jian-Xun Wang, Zhibin Wang, Tao Yu   +9 more
semanticscholar   +1 more source

Lactate promotes endothelial-to-mesenchymal transition via Snail1 lactylation after myocardial infarction

Science Advances, 2023
High levels of lactate are positively associated with the prognosis and mortality in patients with heart attack. Endothelial-to-mesenchymal transition (EndoMT) plays an important role in cardiac fibrosis.
Min Fan, Kun Yang, Xiaohui Wang, Linjian Chen, P. Gill, T. Ha, Li Liu, Nicole H Lewis, David L. Williams, Chuanful Li   +9 more
semanticscholar   +1 more source

Lactate activates the mitochondrial electron transport chain independent of its metabolism

Molecules and Cells, 2023
SUMMARY Lactate has long been considered a cellular waste product. However, we found that as extracellular lactate accumulates, it also enters the mitochondrial matrix and stimulates mitochondrial electron transport chain (ETC) activity.
Xin Cai, Charles Ng, Olivia Jones, Tak Shun Fung, Keunwoo Ryu, Dayi Li, Craig B. Thompson   +6 more
semanticscholar   +1 more source

Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-β signaling in regulatory T cells.

Cell Reports, 2022
Regulatory T (Treg) cells play a vital role in maintaining the immunosuppressive tumor microenvironment. Lactate is a crucial metabolite in cancer and is related to tumor prognosis, metastasis, and overall survival. In this study, we focus on the effects
J. Gu, Jinren Zhou, Qiuyang Chen, Xiaozhang Xu, Ji Gao, Xiangyu Li, Qing Shao, Bo Zhou, Haoming Zhou, Song Wei, Qi Wang, Yuan Liang, Ling Lu   +12 more
semanticscholar   +1 more source