Results 41 to 50 of about 568,053 (260)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

NMR-invisible lactate in blood plasma

, 1988
Resonances for lactate are broadened in 500 MHz 1H NMR spectra of human blood plasma and only about one-third is visible in Hahn spin-echo spectra. Similar effects are observed for some other carboxylate anions.
Sadler, P.J., Peter J. Sadler, Brown, J.C.C., Gina Kubal, Jimmy D. Bell, Kubal, G., Bell, J.D., Judith C.C. Brown   +7 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Quick sequential organ failure assessment score, lactate, and neutrophil–lymphocyte ratio help in diagnosis and mortality prediction during golden hour of sepsis in emergency department

Journal of Emergencies, Trauma and Shock, 2023
Introduction: Sepsis is a life-threatening condition with a very narrow golden period in which confirmatory diagnosis may change the outcome dramatically. No confirmatory biomarker is available till date for early diagnosis of sepsis. This study aimed to
Rakesh Kumar, Babu Kattimani, Pushpanjali R Ojha, Udaykumar J Khasage   +3 more
doaj   +1 more source

Source, triggers and clinical implications of hyperlactemia in patients undergoing mitral valve surgery using Custodiol cardioplegia [PDF]

, 2013
Postoperative blood hyperlactaemia is an indicator of organ anaerobic metabolism and is associated with morbidity after cardiac surgery. This prospective study aims to explore the source, triggers and clinical implications for hyperlactaemia in patients ...
Zanchettin, Chiara, Angelini, Gianni D, Zoffoli, Giampaolo, Suleiman, M.Saadeh, Ascione, Raimondo, Polesel, Elvio, Mangino, Domenico, Venturini, Andrea   +7 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

A Platinized Carbon Fiber Microelectrode-Based Oxidase Biosensor for Amperometric Monitoring of Lactate in Brain Slices

Sensors, 2022
Background: Direct and real-time monitoring of lactate in the extracellular space can help elucidate the metabolic and modulatory role of lactate in the brain.
Cândida Dias, Eliana Fernandes, Rui M. Barbosa, Ana Ledo   +3 more
doaj   +1 more source

cosgriffc/lactate-discordance: LD-Classifier Practicum Version

, 2018
Modeling phenotype-lactate discordance.
C. V. Cosgriff
core   +1 more source

Evaluation of nanofiltration for the purification of an organic acid fermentation broth [PDF]

, 2006
This study focuses on a possible elimination of glucose from a sodium lactate fermentation broth by nanofiltration (NF). The results obtained with single-solute solutions indicate that glucose is clearly more retained that sodium lactate.
Roux-de Balmann, Hélène, Roux De-Balmann, Hélène, Lutin, Florence, Bouchoux, Antoine   +3 more
core   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source