Results 51 to 60 of about 568,053 (260)

The Crosstalk between GPR81/IGFBP6 Promotes Breast Cancer Progression by Modulating Lactate Metabolism and Oxidative Stress

Antioxidants, 2022
Breast cancer is the most frequent tumor and the leading cause of cancer deaths in women. In recent years, lactate metabolism and, in particular, its receptor GPR81 have been shown to play a vital role in cancer biology.
Lucia Longhitano, Stefano Forte, Laura Orlando, Stephanie Grasso, Alessandro Barbato, Nunzio Vicario, Rosalba Parenti, Paolo Fontana, Angela M. Amorini, Giuseppe Lazzarino, Giovanni Li Volti, Michelino Di Rosa, Arcangelo Liso, Barbara Tavazzi, Giacomo Lazzarino, Daniele Tibullo   +15 more
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Lactate clearance as a predictor of mortality in critically ill children – A single center prospective observational study

Journal of Pediatric Critical Care
Background: Hyperlactatemia is a common finding in critically ill children and has a strong association with mortality. Lactate clearance (LC) correlates better with mortality than single-point estimation of lactate.
Utkarsha A. Kurade, Aditya V. Kurade, Sara Subodh Dhanawade   +2 more
doaj   +1 more source

Metabolic Reprogramming of Glioblastoma Cells during HCMV Infection Induces Secretome-Mediated Paracrine Effects in the Microenvironment

Viruses, 2022
Glioblastoma (GBM) is an aggressive primary central nervous system neoplasia with limited therapeutic options and poor prognosis. Following reports of cytomegalovirus (HCMV) in GBM tumors, the anti-viral drug Valganciclovir was administered and found to ...
Mark A. A. Harrison, Emily M. Hochreiner, Brooke P. Benjamin, Sean E. Lawler, Kevin J. Zwezdaryk   +4 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Lactate and lactylation in liver diseases: energy metabolism, inflammatory immunity and tumor microenvironment

Frontiers in Immunology
Liver diseases pose a significant threat to human health. Lactate, a byproduct of glycolysis, serves various biological functions, including acting as an energy source, a signaling molecule, and a substrate for lactylation. Lactylation is a novel lactate-
Shiyi Cheng, Xiaoyu Xiao, Dingye Wang, Xiyuan Wang, Minlan Yang   +4 more
doaj   +1 more source

Energy Metabolism in Mouse Sciatic Nerve A Fibres during Increased Energy Demand

Metabolites, 2022
The ability of sciatic nerve A fibres to conduct action potentials relies on an adequate supply of energy substrate, usually glucose, to maintain necessary ion gradients.
Laura R. Rich, Bruce R. Ransom, Angus M. Brown   +2 more
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Serine biosynthesis with one carbon catabolism represents a novel pathway for ATP generation in cells using alternative glycolysis with zero net ATP production [PDF]

, 2011
Recent experimental evidence indicates that some cancer cells have an alternative glycolysis pathway with net zero ATP production, implying that upregulation of glycolysis in these cells may not be related to the generation of ATP.
Elke K. Markert, Alexei Vazquez, Elke Markert, Zoltan Oltvai, Zoltan N. Oltvai   +4 more
core   +3 more sources

Effect of Vitamin C Supplementation on Lipid Peroxidation and Lactate Levels in Individuals Performing Exhaustion Exercise

Annals of Applied Sport Science, 2017
Background. Exercise has significant affects on free radical production. Objective. The objective of the present study was to explore the effect of vitamin C supplementation on lipid peroxidation and lactate levels in sedentary individuals who performed ...
Süleyman Patlar, Abdulkerim Kasim Baltaci, Rasim Mogulkoc, Mehmet Gunay   +3 more
doaj