Results 51 to 60 of about 553,288 (303)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Modeling Challenge Data to Quantify Endogenous Lactate Production

Frontiers in Endocrinology, 2021
With the intention of isolating the susceptibility of modeling methodology to influence our investigation of the infusion data, we used three kinetic approaches to our models: a simple approach, a unit approach, and a novel approach.
Darko Stefanovski, Pamela A. Wilkins, Raymond C. Boston   +2 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The diagnostic accuracy of different fetal blood sample lactate cutoffs in labor, utilizing the StatStrip Xpress® lactate‐meter: A population‐based observational study

Acta Obstetricia et Gynecologica Scandinavica
Introduction A recent study recommended 5.2 mmol/L as a cutoff for fetal blood sample (FBS) lactate in labor for the StatStrip Lactate®/Lactate Xpress® lactate meter.
Magnus B. Berge, Jørg Kessler, Anne Cathrine Staff, Anne Flem Jacobsen   +3 more
doaj   +1 more source

A Rapid Increase in Serum Lactate Levels after Cardiovascular Surgery Is Associated with Postoperative Serious Adverse Events: A Single Center Retrospective Study

Diagnostics
Background/Objectives: Hyperlactatemia is a common predictive factor for poor post-cardiovascular surgery outcomes. However, it is not well understood whether the rapid postoperative lactate level elevation in a short period of time is associated with ...
Kenichiro Kikuchi, Satoshi Kazuma, Yoshiki Masuda   +2 more
doaj   +1 more source

Lactate-levels (mg/dl; mean ± SD) before and after exercise and mean (± SD) increases in lactate levels (mg/dL) after exercise in the pimobendan- and placebo-group.

, 2019
Lactate-levels (mg/dl; mean ± SD) before and after exercise and mean (± SD) increases in lactate levels (mg/dL) after exercise in the pimobendan- and placebo-group.
Ingo Nolte (50031), Leona Wall (5394929), Anna Pilgram (7460753), Karl Rohn (555695), Jan-Peter Bach (3288693), Jonathan Raue (7038890), Maximiliane Sehn (7460756), Nayeli Iwanuk (7460747), Katja Rumstedt (7460750)   +8 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Regulatory role and therapeutic prospect of lactate modification in cancer

Frontiers in Pharmacology
Post-translational modifications (PTMs) of proteins refer to the process of adding chemical groups, sugars, or other molecules to specific residues of target proteins following their biosynthesis by ribosomes.
Mengdi Sun, Kejing Wang, Fang Lu, Donghua Yu, Shumin Liu   +4 more
doaj   +1 more source

cosgriffc/lactate-discordance: LD-Classifier Practicum Version

, 2018
Modeling phenotype-lactate discordance.
C. V. Cosgriff
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source