Results 51 to 60 of about 505,953 (316)

Molecular crowding defines a common origin for the Warburg effect in proliferating cells and the lactate threshold in muscle physiology

, 2011
Aerobic glycolysis is a seemingly wasteful mode of ATP production that is seen both in rapidly proliferating mammalian cells and highly active contracting muscles, but whether there is a common origin for its presence in these widely different systems is
Vazquez, Alexei, Oltvai Zoltán N., Vazquez, A, Zoltán N Oltvai, Alexei Vazquez, Vazquez Alexei, Oltvai, ZN, Oltvai, Zoltán N., Zoltán N. Oltvai   +8 more
core   +1 more source

Lactylation: The emerging frontier in post-translational modification

Frontiers in Genetics
Lactate, a metabolic byproduct, has gained recognition as a highly influential signaling molecule. Lactylation, an emerging form of post-translational modification derived from lactate, plays a crucial role in numerous cellular processes such as ...
Zhou Lu, Xueting Zheng, Mingsong Shi, Yuan Yin, Yuanyuan Liang, Zhiyan Zou, Chenghe Ding, Yuanjing He, Yan Zhou, Xiaoan Li, Xiaoan Li   +10 more
doaj   +1 more source

Tetracycline and Lactation

The Journal of the American Dental Association, 1983
The Journal of the American Dental Association 107 (1983) 12,14-12,14.
UNIVERSITY OF FLORIDA, GAINESVILLE, FLAUNIVERSITY OF FLORIDAGAINESVILLEFLA ( host institution ), Hendeles, Leslie, Trask, Philip A.   +2 more
openaire   +3 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Lactate-levels (mg/dl; mean ± SD) before and after exercise and mean (± SD) increases in lactate levels (mg/dL) after exercise in the pimobendan- and placebo-group.

, 2019
Lactate-levels (mg/dl; mean ± SD) before and after exercise and mean (± SD) increases in lactate levels (mg/dL) after exercise in the pimobendan- and placebo-group.
Ingo Nolte (50031), Leona Wall (5394929), Anna Pilgram (7460753), Karl Rohn (555695), Jan-Peter Bach (3288693), Jonathan Raue (7038890), Maximiliane Sehn (7460756), Nayeli Iwanuk (7460747), Katja Rumstedt (7460750)   +8 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

cosgriffc/lactate-discordance: LD-Classifier Practicum Version

, 2018
Modeling phenotype-lactate discordance.
C. V. Cosgriff
core   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

A lactate metabolism-related signature predicting patient prognosis and immune microenvironment in ovarian cancer

Frontiers in Endocrinology
IntroductionOvarian cancer (OV) is a highly lethal gynecological malignancy with a poor prognosis. Lactate metabolism is crucial for tumor cell survival, proliferation, and immune evasion.
Linhua Zhu, Zhuoqun Lin, Kai Wang, Kai Wang, Jiaxin Gu, Xiaojing Chen, Ruizhe Chen, Lingfang Wang, Xiaodong Cheng   +8 more
doaj   +1 more source