Results 71 to 80 of about 553,288 (303)

Copper induction of lactate oxidase of Lactococcus lactis: a novel metal stress response

, 2007
Lactococcus lactis IL1403, a lactic acid bacterium widely used for food fermentation, is often exposed to stress conditions. One such condition is exposure to copper, such as in cheese making in copper vats.
Barré, Olivier, Mourlane, Frédéric, Olivier Barré, Solioz, Marc, Frédéric Mourlane, Marc Solioz, Lactate Oxidase   +6 more
core   +1 more source

Pediatric Mediastinal Gray Zone Lymphoma With Germline TET2 Heterozygous Variant

Pediatric Blood &Cancer, EarlyView.
Matthew R. Schuelke, Julia Wang, Haley Newman, Evelyn Kurpiewski, Anne Reilly, Susan R. Rheingold, Gerald Wertheim, Moe Takeda, Daniel J. Zheng, Kaitlin Devine   +9 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Metabolic reprogramming of astrocytes: Emerging roles of lactate

Neural Regeneration Research
Lactate serves as a key energy metabolite in the central nervous system, facilitating essential brain functions, including energy supply, signaling, and epigenetic modulation.
Zeyu Liu, Yijian Guo, Ying Zhang, Yulei Gao, Bin Ning   +4 more
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Evaluation of methods to quantify aerobic-anaerobic energy contributions during sports and exercise — a systematic review and best-evidence synthesis

Frontiers in Sports and Active Living
IntroductionEnergy metabolism during sports and exercise involves both aerobic and anaerobic pathways, with anaerobic contribution playing a key role in various decisive moments during competition.
Christin Ambaum, Matthias W. Hoppe
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Effects of oral, oronasal, and oronasal breathing with a decongested nose during incremental maximal exercise testing of well-trained endurance athletes: a randomized cross-over study

Frontiers in Physiology
IntroductionNasal breathing is preferable for persons at rest and remains partially active during oronasal breathing in exercise. However, its potential contribution to performance–particularly in cases with a decongested nose–remains understudied in ...
J. Bergqvist, J. Bergqvist, F. Reite, F. Edin, L. Schiöler, M. Börjesson, M. Börjesson, S. Steinsvåg, S. Pettersson, J. Hellgren, J. Hellgren   +10 more
doaj   +1 more source

Lactate in a Laubenpieper [PDF]

Nephrology Dialysis Transplantation, 2005
Acid-base disorders seldom kill; however, the mechanisms and associated complications certainly do. We recently encountered a patient with a mysterious lactic acidosis. The patient proved to be a most capable teacher of important lessons.
Wolfgang, Derer, Saban, Elitok, Theresa, Claus, Henry, Schütt, Rainer, Ruf, Ralph, Kettritz, Friedrich C, Luft, Bernard, Pilz   +7 more
openaire   +2 more sources