Results 61 to 70 of about 505,953 (316)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Cerebral Circulation and Metabolism of Patients with Cerebral Injury

Общая реаниматология, 2018
The purpose of the study was to asses changes in cerebral macrocirculation and metabolism parameters in patients with concomitant cerebral injury during infusions of ethylmethylhydroxypyridine succinate at a dose of 12.5 to 100 mg/h depending on a source
Ekaterina A. Abramova, Oleg V. Voennov, Gennadii A. Boyarinov, Аlexei O. Trofimov   +3 more
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

The role of lactate-induced protein lactylation in gliomas: implications for preclinical research and the development of new treatments

Frontiers in Pharmacology
The most prevalent primary brain tumors in adults are gliomas. In addition to insufficient therapeutic alternatives, gliomas are fatal mostly due to the rapid proliferation and continuous infiltration of tumor cells into the surrounding healthy brain ...
Xiaoying Liu, Yue Zhou, Haichuan Wang
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Causes of metabolic acidosis in canine hemorrhagic shock : role of unmeasured ions [PDF]

, 2007
Introduction: Metabolic acidosis during hemorrhagic shock is common and conventionally considered to be due to hyperlactatemia. There is increasing awareness, however, that other nonlactate, unmeasured anions contribute to this type of acidosis ...
Faithfull, N. Simon, Bruegger, Dirk, Jacob, Matthias, Keipert, Peter E., Becker, Bernhard F., Kristian B Packert, Rehm, Markus, Habler, Oliver P., Bernhard F Becker, Markus Rehm, Franz G Meisner, Meisner, Franz G., Oliver P Habler, Meisner, Franz Georg, Packert, Kristian B., Christoph J Wojtczyk, Packert, Kristian, Wojtczyk, Christoph J., Dirk Bruegger, Brügger, Dirk Steffen, Gregor I Kemming, Kemming, Gregor I., Habler, Oliver, Matthias Jacob, Peter E Keipert, N Simon Faithfull   +25 more
core   +1 more source

Lactate administration induces skeletal muscle synthesis by influencing Akt/mTOR and MuRF1 in non‐trained mice but not in trained mice

Physiological Reports
The perception regarding lactate has changed over the past decades, and some of its physiological roles have gradually been revealed. However, the effects of exogenous lactate on skeletal muscle synthesis remain unclear.
Sunghwan Kyun, Jisu Kim, Deunsol Hwang, Inkwon Jang, Hun‐Young Park, Kiwon Lim   +5 more
doaj   +1 more source

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source

Copper induction of lactate oxidase of Lactococcus lactis: a novel metal stress response

, 2007
Lactococcus lactis IL1403, a lactic acid bacterium widely used for food fermentation, is often exposed to stress conditions. One such condition is exposure to copper, such as in cheese making in copper vats.
Barré, Olivier, Mourlane, Frédéric, Olivier Barré, Solioz, Marc, Frédéric Mourlane, Marc Solioz, Lactate Oxidase   +6 more
core   +1 more source

Effects of two resistance training methods with different rest intervals on muscular strength and power and blood lactate level [PDF]

فصلنامه ابن سینا, 2014
Background: Researchers, coaches and athletes are constantly looking for the most effective and efficient ways to enhance athletic performance. The aim of this study was to investigate the response effects of two resistance training methods with ...
R eslami, F khajavi rad, V valipour dehnou   +2 more
doaj