Results 31 to 40 of about 718,278 (311)

Quantitative constraint-based computational model of tumor-to-stroma coupling via lactate shuttle [PDF]

, 2015
Cancer cells utilize large amounts of ATP to sustain growth, relying primarily on non-oxidative, fermentative pathways for its production.
CAPUANI, FABRIZIO, DE MARTINO, ANDREA, DE MARTINO, DANIELE, MARINARI, Vincenzo   +3 more
core   +3 more sources

High level of intraoperative lactate might predict acute kidney injury in aortic arch surgery via minimally invasive approach in patients with type A dissection

Frontiers in Cardiovascular Medicine, 2023
BackgroundA high incidence of acute kidney injury (AKI) has been recorded in total arch replacement (TAR) combined with frozen elephant trunk (FET) implantation in patients with acute type A dissection (ATAAD) via median sternotomy approach with some ...
Ying Lyu, Yu Liu, Xiong Xiao, Xiong Xiao, Zhonglu Yang, Yuguang Ge, Hui Jiang   +6 more
doaj   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Blood and salivary lactate responses to active rest following circuit exercise

Frontiers in Physiology
The present study investigated blood and salivary lactate concentrations with or without active recovery following intensive exercise. Seven men and four women were randomly assigned to two trials consisting of a control (CON) trial and an active ...
Chihiro Kojima, Takuma Morishima, Reita Ito, Sosuke Yasunaga, Takumi Shimogaki, Takeshi Hashimoto, Tadao Isaka, Motoyuki Iemitsu   +7 more
doaj   +1 more source

Blood lactate clearance after maximal exercise depends on active recovery intensity [PDF]

, 2014
AIM: High-intensity exercise is time-limited by onset of fatigue, marked by accumulation of blood lactate. This is accentuated at maximal, all-out exercise that rapidly accumulates high blood lactate.
Devlin, J., Ferguson, C., Kemi, O. J., Paton, B., Poole, L., Sun, W., Wilson, J.   +6 more
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Serum lactate as a prognostic factor in coronary artery bypass graft operation by on pump method [PDF]

, 2013
Background: Lactic acidosis in cardiac surgical patients is a manifestation of systemic inflammation and excess pro-inflammatory cytokine production. This investigation was designed to integrate basic concepts about lactate acidosis with a clinically ...
Alereza, H., Alijanpour, E., Banihashem, N., Jabbari, A., Rabiee, S.M., Vafaey, H.R.   +5 more
core   +1 more source

Incorporating expression data in metabolic modeling: a case study of lactate dehydrogenase

, 2005
Integrating biological information from different sources to understand cellular processes is an important problem in systems biology. We use data from mRNA expression arrays and chemical kinetics to formulate a metabolic model relevant to K562 ...
Akesson, Baker, Barkai, Borgmann, Dang, Fan, Ferea, Goodacre, Griffiths, Gross, Joel R. Sevinsky, Joshua Downer, Jungmann, Kal, Karan, Katheryn A. Resing, Kim, Kitano, Kondoh, Koslowski, Koukourakis, Lambeth, Lewis, Lewis, Li, M.D. Betterton, Maekawa, Mazurek, Mulquiney, Munoz-Pinedo, Natalie G. Ahn, Newell, Osthus, Papas, Press, Riera, Segal, Sevinsky, Shim, Stambaugh, Stephanopoulos, Stubbs, Tilton, Unwin, Voet, von Dassow, Walenta, Warburg   +47 more
core   +1 more source

Inspiratory muscle training abolishes the blood lactate increase associated with volitional hyperpnoea superimposed on exercise and accelerates lactate and oxygen uptake kinetics at the onset of exercise [PDF]

, 2011
We examined the effects of inspiratory muscle training (IMT) upon volitional hyperpnoea-mediated increases in blood lactate ([lac−]B) during cycling at maximal lactate steady state (MLSS) power, and blood lactate and oxygen uptake kinetics at the onset ...
Brown, PI, Johnson, MA, Sharpe, GR
core   +2 more sources