Results 31 to 40 of about 568,053 (260)

Increasing Rate of Fatal Streptococcus pyogenes Bacteriemia—A Challenge for Prompt Diagnosis and Appropriate Therapy in Real Praxis

Microorganisms
Streptococcus pyogenes, group A streptococci (GAS) bacteriaemia, is a life-threatening infection with high mortality, requiring fast diagnosis together with the use of appropriate antibiotic therapy as soon as possible.
Vaclava Adamkova, Vanda Gabriela Adamkova, Gabriela Kroneislova, Jan Zavora, Marie Kroneislova, Michal Huptych, Helena Lahoda Brodska   +6 more
doaj   +1 more source

Clinical Value of the Lactate/Albumin Ratio and Lactate/Albumin Ratio × Age Score in the Assessment of Prognosis in Patients With Sepsis

Frontiers in Medicine, 2021
Objective: To examine the clinical significance of the blood lactate (Lac)/serum albumin (Alb) ratio and the Lac/Alb × age score for assessing the severity and prognosis of patients with sepsis.Methods: A total of 8,029 patients with sepsis, aged >18 ...
Xiaonan Chen, Xinjian Zhou, Hui Zhao, Yanxue Wang, Hong Pan, Ke Ma, Zhijie Xia   +6 more
doaj   +1 more source

CSF lactate dehydrogenase activity in patients with Creutzfeldt-Jakob disease exceeds that in other dementias [PDF]

, 2004
The diagnosis of Creutzfeldt- Jakob disease (CJD) is still made by exclusion of other dementias. We now evaluated lactate dehydrogenase (LDH) in the cerebrospinal fluid (CSF) as a possible additional diagnostic tool. CSF LDH levels of patients with CJD (
Cepek, L., Niedmann, P., Poser, S., Otto, M., Kretzschmar, Hans A., Otto, Markus, Poser, Sigrid, Schmidt, H., Schroter, A., Kretzschmar, H. A.   +9 more
core   +1 more source

Progress in Lactate Metabolism and Its Regulation via Small Molecule Drugs

Molecules
Lactate, once viewed as a byproduct of glycolysis and a metabolic “waste”, is now recognized as an energy-providing substrate and a signaling molecule that modulates cellular functions under pathological conditions.
Jin Liu, Feng Zhou, Yang Tang, Linghui Li, Ling Li   +4 more
doaj   +1 more source

Correction of Hypoxia and Free Radical Oxidation Processes in Gastroduodenal Hemorrhages

Общая реаниматология, 2007
The present investigation was to study the clinical efficacy of the substrate antihypoxant-antioxidant Reamberin used in the correction of tissue hypoxia and free radical oxidation (FRO) in patients with severe blood loss of ulcerous etiology.
S. S. Morgunov, A. V. Matveyev
doaj   +1 more source

Insights into the Effect of Catalytic Intratumoral Lactate Depletion on Metabolic Reprogramming and Immune Activation for Antitumoral Activity

Advanced Science, 2023
Lactate, a characteristic metabolite of the tumor microenvironment (TME), drives immunosuppression and promotes tumor progression. Material‐engineered strategies for intratumoral lactate modulations demonstrate their promise for tumor immunotherapy ...
Junlong Zhao, Zhimin Tian, Shoujie Zhao, Dayun Feng, Zhixiong Guo, Liangzhi Wen, Yejing Zhu, Fenghua Xu, Jun Zhu, Shouzheng Ma, Jie Hu, Tao Jiang, Yongquan Qu, Dongfeng Chen, Lei Liu   +14 more
doaj   +1 more source

Lactate Dehydrogenase A or B Knockdown Reduces Lactate Production and Inhibits Breast Cancer Cell Motility in vitro

Frontiers in Pharmacology, 2021
Background: Lactate dehydrogenase (LDH) plays an important role in cancer pathogenesis and enhanced expression/activity of this enzyme has been correlated with poor prognosis. In this study we determined the expression profile of LDH-A and B in normal as
Maitham A. Khajah, Sarah Khushaish, Yunus A. Luqmani   +2 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Pre-ischemic Lactate Levels Affect Post-ischemic Recovery in an Isolated Rat Heart Model of Donation After Circulatory Death (DCD)

Frontiers in Cardiovascular Medicine, 2021
Introduction: Donation after circulatory death (DCD) could substantially improve donor heart availability. In DCD, the heart is not only exposed to a period of warm ischemia, but also to a damaging pre-ischemic phase.
Maria Arnold, Maria Arnold, Adrian Segiser, Adrian Segiser, Selianne Graf, Selianne Graf, Natalia Méndez-Carmona, Natalia Méndez-Carmona, Maria N. Sanz, Maria N. Sanz, Rahel K. Wyss, Rahel K. Wyss, Nina Kalbermatter, Nina Kalbermatter, Nino Keller, Nino Keller, Thierry Carrel, Thierry Carrel, Sarah Longnus, Sarah Longnus   +19 more
doaj   +1 more source

Circulating anions usually associated with the Krebs cycle in patients with metabolic acidosis [PDF]

, 2005
Introduction: Acute metabolic acidosis of non-renal origin is usually a result of either lactic or ketoacidosis, both of which are associated with a high anion gap.
Treacher, David F, Forni, L.G., Forni, Lui G, William McKinnon, Gwyn A Lord, Hilton, Philip J, Peron, Jean-Marie R, McKinnon, W., McKinnon, William, Lord, Gwyn A, Hilton, P.J., Philip J Hilton, David F Treacher, Treacher, D.F., Lui G Forni, Lord, Gwyn A., Peron, J.M.R., Jean-Marie R Peron   +17 more
core   +1 more source