Results 61 to 70 of about 128,524 (232)

Lactylation‐Driven PROS1‐TYRO3‐CARF Signaling Promotes Therapy‐Induced Senescence Escape and Radioresistance in Meningioma

Advanced Science, EarlyView.
A glycolysis‐driven epigenetic switch promotes therapy resistance in meningioma. Increased lactate production enhances histone H3K27 lactylation, which activates PROS1 secretion. Secreted PROS1 engages TYRO3 signaling to degrade the senescence regulator CARF, allowing cancer cells to escape growth arrest.
Zhuohang Wang, Qixiang Zhang, Keman Liao, Xiaoyu Liu, Hongchi Zhang, Yunsheng Chen, Yuxiao Ma, Yikui Liu, Aoqian Xu, Yuhao Sun, Jiayi Chen, Liuguan Bian, Baofeng Wang   +12 more
wiley   +1 more source

Histone lactylation in macrophages is predictive for gene expression changes during ischemia induced-muscle regeneration

Molecular Metabolism
Objectives: We have previously shown that lactate is an essential metabolite for macrophage polarisation during ischemia-induced muscle regeneration. Recent in vitro work has implicated histone lactylation, a direct derivative of lactate, in macrophage ...
Thibaut Desgeorges, Eva Galle, Jing Zhang, Ferdinand von Meyenn, Katrien De Bock   +4 more
doaj   +1 more source

Lactate and lactylation: molecular insights into histone and non-histone lactylation in tumor progression, tumor immune microenvironment, and therapeutic strategies

Biomarker Research
Abstract Investigating cancer metabolism is of paramount importance for understanding tumor biology and developing novel therapeutic strategies. Lactylation, a posttranslational modification facilitated by the glycolytic product lactate, plays a crucial role in regulating oncogenic signalling pathways.
Xiao, Shuying, Zhang, Suhang, Sun, Kai, Huang, Qibo, Li, Qilin, Hu, Chuanyu   +5 more
openaire   +2 more sources

Research Progress of Lactylation in Age-related Diseases [PDF]

Lactylation (Kla) is a novel mechanism of protein post-translational modification, which is formed by covalent coupling of lactate produced by glycolysis with lysine residues, mainly including histone lactylation and non-histone lactylation.
WU Miaomiao, LI Pengfei, XU Linhui, KANG Lihua, JI Min, WANG Yong, GUAN Huaijin
core   +1 more source

Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2

Advanced Science, EarlyView.
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang, Chuanzan Zhou, Jiaoyan He, Pengpeng Huang, Rong Zhang, Huan Hu, Meng Jiao, Linyi Hu, Feng Liu, Xiaolong Qi, Xiang He, Yunkai Yang, Y Eugene Chinn, Dechao Feng, Dahong Zhang, Qi Zhang   +15 more
wiley   +1 more source

Positive feedback regulation between glycolysis and histone lactylation drives oncogenesis in pancreatic ductal adenocarcinoma

Molecular Cancer
Background Metabolic reprogramming and epigenetic alterations contribute to the aggressiveness of pancreatic ductal adenocarcinoma (PDAC). Lactate-dependent histone modification is a new type of histone mark, which links glycolysis metabolite to the ...
Fei Li, Wenzhe Si, Li Xia, Deshan Yin, Tianjiao Wei, Ming Tao, Xiaona Cui, Jin Yang, Tianpei Hong, Rui Wei   +9 more
doaj   +1 more source

Lysine lactylation regulates ATF4-mediated stress responses under glucose starvation in canine hemangiosarcoma

Frontiers in Veterinary Science
Excess lactate is produced in tumor cells by aerobic glycolysis and regulates gene expressions by histone lactylation. However, how histone lactylation functions under glucose-limited conditions remains unknown.
Tamami Suzuki, Kazuki Heishima, Kazuki Heishima, Kazuki Heishima, Jumpei Yamazaki, Jumpei Yamazaki, Masaya Yamazaki, Ryohei Kinoshita, Ryohei Kinoshita, Sangho Kim, Sangho Kim, Sangho Kim, Kenji Hosoya, Kenji Hosoya, Kenji Hosoya, Yuko Okamatsu-Ogura, Michihito Sasaki, Peng Xu, Qin Yan, Takashi Kimura, Keisuke Aoshima, Keisuke Aoshima   +21 more
doaj   +1 more source

H4K79 and H4K91 histone lactylation, newly identified lactylation sites enriched in breast cancer

Journal of Experimental & Clinical Cancer Research
Abstract Metabolic reprogramming and epigenetic modification are two hallmarks of cancer. Protein lysine lactylation (Kla) is a novel type of glycolysis lactate-triggered posttranslational modification. However, the role of Kla in breast cancer (BC) remains largely unknown.
Liu, Jiena, Zhao, Liuying, Yan, Meisi, Jin, Shengye, Shang, Lingmin, Wang, Jianyu, Wang, Qin, Zhao, Shilu, Shen, Zibo, Liu, Tong, Wu, Hao, Pang, Da   +11 more
openaire   +2 more sources

Histone lactylation: a new epigenetic axis for host-parasite signalling in malaria?

, 2022
Epigenetic modifications play important roles in the biology of malaria parasites. The new epigenetic mark histone lactylation, discovered only recently in humans, is also present in malaria parasites.

core   +2 more sources

Puerarin‑Loaded pH‑Responsive ZIF‑90 Nanoparticles Ameliorate Osteoporosis via Enhancing H3K18 Lactylation and Suppressing Aberrant Osteoclast Activation

Advanced Science, EarlyView.
Schematic illustration of the mechanism by which ZIF‐90@PU alleviates osteoporosis via H3K18la‐mediated NFATc1 pathway suppression. ABSTRACT Osteoporosis is characterized by dysregulated osteoclast activity, leading to excessive bone resorption and structural damage.
Jiajia Lu, Yue Xi, Sheng Wang, Ye Chen, Jiajie Yang, Xiaojian Shi   +5 more
wiley   +1 more source