Results 61 to 70 of about 4,116 (175)

Lactate‐Primed NETosis Modulates Hepatic Regeneration During Acute Liver Failure via the TLR9/KLF15/AJUBA Axis

Cell Proliferation, EarlyView.
This study elucidates a novel Kupffer cell‐neutrophil‐hepatocyte axis that drives metabolic‐immune crosstalk during acute liver failure. Specifically, lactate‐primed NETs release links metabolic reprogramming to NETosis‐induced regenerative failure in hepatocytes via the TLR9/KLF15/AJUBA axis.
Jin Guo, Xiaoya Zhang, Danmei Zhang, Chunxia Shi, Luwen Wang, Zuojiong Gong   +5 more
wiley   +1 more source

Therapeutic potential of microglial SMEK1 in regulating H3K9 lactylation in cerebral ischemia-reperfusion

Communications Biology
Acute ischemic stroke (AIS) triggers immune responses and neuroinflammation, contributing to brain injury. Histone lactylation, a metabolic stress-related histone modification, plays a critical role in various diseases, but its involvement in cerebral ...
Wei-Yue Si, Chun-Lin Yang, Shu-Li Wei, Tong Du, Liang-Kang Li, Jing Dong, Yang Zhou, Heng Li, Peng Zhang, Qi-Ji Liu, Rui-Sheng Duan, Ruo-Nan Duan   +11 more
doaj   +1 more source

Protein Lactylation: A new jewel in the crown

Asian Journal of Medical Sciences
Lactylation is a newly identified post-translational modification that has emerged as a crucial epigenetic regulator, significantly influencing cellular functions and disease processes. Lactylation involves the addition of lactate, a glycolysis byproduct,
Ruby Dhar , Arun Kumar , Subhradip Karmakar   +2 more
doaj   +1 more source

Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases

Cell Proliferation, EarlyView.
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du, Joshua S. Fleishman, Shuang Wu, Yuan Zhou, Clara X. Wang, Haitong Wang, Yumin Wang, Hongquan Wang   +7 more
wiley   +1 more source

Enhanced glycolysis-derived lactate promotes microglial activation in Parkinson’s disease via histone lactylation

npj Parkinson's Disease
The switch from oxidative phosphorylation to glycolysis is crucial for microglial activation. Recent studies highlight that histone lactylation promotes macrophage homeostatic gene expression via transcriptional regulation, but its role in microglia ...
Qixiong Qin, Danlei Wang, Yi Qu, Jiangting Li, Ke An, Zhijuan Mao, Jingyi Li, Yongjie Xiong, Zhe Min, Zheng Xue   +9 more
doaj   +1 more source

Histone H3k18 Lactylation Promotes Oral Carcinogenesis By Regulating Pyrimidine Metabolism

International Dental Journal
Aim or purpose: Metabolic reprogramming and epigenetic alterations promote oral squamous cell carcinoma (OSCC). Lactate-dependent histone modification is a new type of histone mark, which links glycolysis metabolite to the epigenetic process of ...
Wang Yanting, Fan Yuan, Geng Yanlin
doaj   +1 more source

Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease

Cell Proliferation, EarlyView.
Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik, Muhammad Dilawar, Junguang Liao, Jie Zheng, Qitao Qian, Ming Xu, Sisi Lin, Xiaobo Zhu, Qiuwei Ge, Limin Jin, Guiqian Chen   +10 more
wiley   +1 more source

Role and Mechanism of Lactylation in Cancer

Chinese Journal of Lung Cancer
Post translational modifications (PTMs) can change the properties of a protein by covalent addition of functional groups to one or more amino acids, and influence almost all aspects of normal cell biology and pathogenesis.
Qicheng ZHANG, Limin CAO, Ke XU
doaj   +1 more source

Lactylation in digestive system tumors: from mechanisms to therapeutic target

Frontiers in Oncology
Lactylation, a recently identified epigenetic modification derived from lactate metabolism, has emerged as a key regulator linking cellular metabolic states to chromatin remodeling and gene transcription.
Jun Wei, Jun Wei, Jun Wei, Qian Ding, Hongjun Wang, Yang Liu   +5 more
doaj   +1 more source

RETRACTION: Histone Lactylation‐Driven Upregulation of VRK1 Expression Promotes Stemness and Proliferation of Glioma Stem Cells

Advanced Science, EarlyView.
Abstract RETRACTION: J. Li, C. Tang, X. Zhang, R. Xing, and Q. Guo, “Histone Lactylation‐Driven Upregulation of VRK1 Expression Promotes Stemness and Proliferation of Glioma Stem Cells,” Advanced Science 12, no. 44 (2025): e03897, https://doi.org/10.1002/advs.202503897.
wiley   +1 more source