Results 81 to 90 of about 4,116 (175)

Protein lactylation in cancer: mechanisms and potential therapeutic implications

Experimental and Molecular Medicine
Increased glycolysis, which leads to high lactate production, is a common feature of cancer cells. Recent evidence suggests that lactate plays a role in the post-translational modification of histone and nonhistone proteins via lactylation.
Hyunsoo Rho, Nissim Hay
doaj   +1 more source

Metabolic Regulation of Macrophages in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang, Yu Zhang, Jiali Min, Jiahui Yang, Yuchen Li, Hao Zhang, Shanshan Liu   +6 more
wiley   +1 more source

Identification of lactylation-associated immune and metabolic regulators in bladder cancer via integrated bulk and single-cell transcriptomics

Frontiers in Immunology
BackgroundLactate-driven metabolic reprogramming and histone lactylation play pivotal roles in bladder cancer (BLCA) progression, yet their underlying mechanisms and regulatory genes remain poorly understood.MethodsUsing transcriptomic data from The ...
Yanjun Chen, Yu Sun, Xiaoyan Liu, Xiaoyan Liu   +3 more
doaj   +1 more source

Glucose Transporter 1 in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
As the quintessential facilitator of basal glucose uptake, glucose transporter 1 (GLUT1) is indispensable for maintaining systemic energy homeostasis. This graphical abstract delineates the multidimensional landscape of GLUT1 in normal physiology. It highlights its tissue‐specific metabolic roles—from fueling erythrocytes and fetal development to ...
Yi Tai, Zhihao Chen, Yuping Zhu, Weidong Han   +3 more
wiley   +1 more source

Oxygen Glucose Deprivation-Induced Lactylation of H3K9 Contributes to M1 Polarization and Inflammation of Microglia Through TNF Pathway

Biomedicines
Background: Hypoxia-induced M1 polarization of microglia and resultant inflammation take part in the damage caused by hypoxic-ischemic encephalopathy (HIE).
Lu He, Rui Yin, Weijian Hang, Jinli Han, Juan Chen, Bin Wen, Ling Chen   +6 more
doaj   +1 more source

Embryonic Mediators of Embryo–Uterus Communication, Implantation and Pregnancy

Molecular Reproduction and Development, Volume 93, Issue 8, August 2026.
ABSTRACT Successful reproduction in eutherian mammals requires intimate connections between the embryo and uterus, involving adhesion, attachment and placentation, with or without invasion of the endometrium. The complex dialogue between embryo and uterus involves numerous molecules and pathways.
Keith E. Latham
wiley   +1 more source

Extracellular lactate improves neurogenesis by modulating H3K9 lactylation and SnoN expression under hypoxic conditions

Stem Cell Research & Therapy
Background Lactate has a beneficial effect on adult neurogenesis and has been identified as a mediator of lactylation of proteins. However, the regulatory role and function of histone lactylation in neurogenesis remain poorly understood. This study aimed
Wenhong Xu, Anqi Zhao, Rui Han, Junyuan Wei, Qi Yu, Miaomiao Wang, Haokun Li, Baofeng Xu, Meiying Li, Guangfan Chi   +9 more
doaj   +1 more source

Activation of the Lactate Receptor GPR81 Ameliorates Senescence Hallmarks and Improves Muscle Function in Cellular and Progeroid Models of Aging

Aging Cell, Volume 25, Issue 8, August 2026.
Skeletal muscle aging is associated with a decrease in expression of the lactate receptor GPR81. Treating senescent myoblasts in vitro and progeric mice in vivo with GPR81 agonist decreases intramyocellular lipid accumulation and reverses hallmarks of aging. ABSTRACT Skeletal muscle aging is associated with increased lipid accumulation, or myosteatosis,
Pihu Mehrotra, Sai Harsha Bhamidipati, Pedro Lei, John Toftegaard, Debanik Choudhury, Maryam Elsayed, Yali Zhang, Jianmin Wang, Shweta Chitkara, G. Ekin Atilla‐Gokcumen, Song Liu, Stelios T. Andreadis   +11 more
wiley   +1 more source

Histone lactylation: from tumor lactate metabolism to epigenetic regulation

International Journal of Biological Sciences
The Warburg Effect is one of the most well-known cancer hallmarks. This metabolic pattern centered on lactate has extremely complex effects on various aspects of tumor microenvironment, including metabolic remodeling, immune suppression, cancer cell migration, and drug resistance development.
Yu, Xiaoning, Yang, Jing, Xu, Jin, Pan, Haoqi, Wang, Wei, Yu, Xianjun, Shi, Si   +6 more
openaire   +2 more sources

Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer

Cancer Science, Volume 117, Issue 8, Page 2064-2084, August 2026.
Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo, Yuqian Feng, Jiamin Lu, Nuerbiye Abudurexiti, Xinlei Zhou, Mengfan Wei, Song Zheng   +6 more
wiley   +1 more source