Results 81 to 90 of about 128,524 (232)

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

Histone H3k18 Lactylation Promotes Oral Carcinogenesis By Regulating Pyrimidine Metabolism

International Dental Journal
Aim or purpose: Metabolic reprogramming and epigenetic alterations promote oral squamous cell carcinoma (OSCC). Lactate-dependent histone modification is a new type of histone mark, which links glycolysis metabolite to the epigenetic process of ...
Wang Yanting, Fan Yuan, Geng Yanlin
doaj   +1 more source

Histone Lactylation in Diseases: Regulation by Traditional Chinese Medicine and Therapeutic Implications

Drug Design, Development and Therapy
Yuyue Qiu, Xiaoni Shao College of Pharmacy and Food, Southwest Minzu University, Chengdu, Sichuan, 610225, People’s Republic of ChinaCorrespondence: Xiaoni Shao, College of Pharmacy and Food, Southwest Minzu University, #168 Dajian Street ...
Qiu Y, Shao X
doaj  

Enhanced glycolysis-derived lactate promotes microglial activation in Parkinson’s disease via histone lactylation

npj Parkinson's Disease
The switch from oxidative phosphorylation to glycolysis is crucial for microglial activation. Recent studies highlight that histone lactylation promotes macrophage homeostatic gene expression via transcriptional regulation, but its role in microglia ...
Qixiong Qin, Danlei Wang, Yi Qu, Jiangting Li, Ke An, Zhijuan Mao, Jingyi Li, Yongjie Xiong, Zhe Min, Zheng Xue   +9 more
doaj   +1 more source

Lactylation in digestive system tumors: from mechanisms to therapeutic target

Frontiers in Oncology
Lactylation, a recently identified epigenetic modification derived from lactate metabolism, has emerged as a key regulator linking cellular metabolic states to chromatin remodeling and gene transcription.
Jun Wei, Jun Wei, Jun Wei, Qian Ding, Hongjun Wang, Yang Liu   +5 more
doaj   +1 more source

Lactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair

Advanced Science, EarlyView.
A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao, Jianzhong Cao, Wenyue Liu, Xuyun Li, Haolin Zhang, Xiaofang Zhang, Shiyang Shi, Huilong Yin, Junjie Li, Angang Yang, Rui Zhang   +10 more
wiley   +1 more source

Role and Mechanism of Lactylation in Cancer

Chinese Journal of Lung Cancer
Post translational modifications (PTMs) can change the properties of a protein by covalent addition of functional groups to one or more amino acids, and influence almost all aspects of normal cell biology and pathogenesis.
Qicheng ZHANG, Limin CAO, Ke XU
doaj   +1 more source

Microglia lactylation in relation to central nervous system diseases [PDF]

The development of neurodegenerative diseases is closely related to the disruption of central nervous system homeostasis. Microglia, as innate immune cells, play important roles in the maintenance of central nervous system homeostasis, injury response ...
Mo, Nan, Hui Yang, Nan Mo, Le Tong, Wang, Ying, Juanqing Yue, Dong, Jianhong, Jianhong Dong, Mengxian Jia, Yang, Hui, Fan, Ziwei, Tong, Lily, Yue, Juanqing, Ying Wang, Jia, Mengxian, Ziwei Fan   +15 more
core   +1 more source

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

Advanced Science, EarlyView.
Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu, Xi Li, Wenxuan He, Fenglin Li, Qican Ou, Yao Liu, Jiang Lei, Yanzi Bao, Huaxin Huang, Wei Feng, Yuanguang Tang, Xiaohui Qiu, Lu Gan, Yuefei Shen, Jin Wang, Yousheng Xiao   +15 more
wiley   +1 more source