Results 101 to 110 of about 128,524 (232)

Histone lactylation bridges metabolic reprogramming and epigenetic rewiring in driving carcinogenesis: Oncometabolite fuels oncogenic transcription

Clinical and Translational Medicine
Heightened lactate production in cancer cells has been linked to various cellular mechanisms such as angiogenesis, hypoxia, macrophage polarisation and T‐cell dysfunction.
Yu Zhang, Hang Song, Meili Li, Peirong Lu   +3 more
doaj   +1 more source

Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory.

Contains fulltext : 319815.pdf (Publisher’s version ) (Open Access)Trained immunity, a de facto innate immune memory characterized by enhanced responsiveness to future challenges, is underpinned by epigenetic and metabolic rewiring.
Galang, N., Tran, K.A., Li, Wenchao, Ferreira, A.V., Ventriglia, Lorenzo, Schlüter, T., Li, Y., Li, X., Joosten, L.A.B., Mhlanga, M.M.K., Ziogas, A., Netea, M.G., Martens, J.H.A., Moorlag, S.J.C.F.M., Divangahi, M., Unen, N. van, Koeken, V.A.C.M., Moyo, M.B., Novakovic, B, Matzaraki, V., Baltissen, M.P.   +20 more
core   +1 more source

Insights into recent findings and therapeutic potential of nonhistone lactylation in cancer [PDF]

Lactylation, a recently identified post-translational modification, has become a crucial regulatory mechanism beyond its conventional metabolic role. Unlike histone lactylation, which regulates gene expression, nonhistone lactylation directly acts on ...
Minbin Chen, Xiaoren Zhu, Na Liu, Jing Jia   +3 more
core   +1 more source

Histone lactylation: from tumor lactate metabolism to epigenetic regulation

International Journal of Biological Sciences
The Warburg Effect is one of the most well-known cancer hallmarks. This metabolic pattern centered on lactate has extremely complex effects on various aspects of tumor microenvironment, including metabolic remodeling, immune suppression, cancer cell migration, and drug resistance development.
Yu, Xiaoning, Yang, Jing, Xu, Jin, Pan, Haoqi, Wang, Wei, Yu, Xianjun, Shi, Si   +6 more
openaire   +2 more sources

Recent Advances in Top‐Down Proteomics for Single‐Cell Research

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Individual cells have distinctive molecular characteristics, including biologically relevant proteoforms. Although single‐cell (SC) molecular omics offer unprecedented insights into cellular heterogeneity and function, the characterization of proteoforms in SCs remains an uncharted territory.
Jake A. Melby, Pei Su, Fabio P. Gomes
wiley   +1 more source

Identification of lactylation-associated immune and metabolic regulators in bladder cancer via integrated bulk and single-cell transcriptomics

Frontiers in Immunology
BackgroundLactate-driven metabolic reprogramming and histone lactylation play pivotal roles in bladder cancer (BLCA) progression, yet their underlying mechanisms and regulatory genes remain poorly understood.MethodsUsing transcriptomic data from The ...
Yanjun Chen, Yu Sun, Xiaoyan Liu, Xiaoyan Liu   +3 more
doaj   +1 more source

Hexokinase-3 upregulation and histone H3K18 lactylation mediate murine liver fibrosis induced by Echinococcus multilocularis

Alveolar echinococcosis (AE), caused by Echinococcus multilocularis infection, leads to destructive hepatic lesions and severe hepatic fibrosis.
Yurun Miao, Xiangyang Yang, Chunfu Li, Jing Liu, Wenbin Yang, Ting Zhang, Wei Hu, Lixian Shan, Wenhui Liu, Yan Wang, Wei Cui, Lei Xiu   +11 more
core   +1 more source

Chronic high‐altitude exposure and intracerebral hemorrhage: A novel perspective from the vascular‐immune‐neuronal network

Neuroprotection, EarlyView.
Long‐term chronic high‐altitude hypobaric hypoxia increases susceptibility to ICH, particularly among migrant populations lacking EPAS1/SENP1 adaptive genetic variants relative to high‐altitude indigenous residents. Persistent hypoxia initiates blood–brain barrier (BBB) breakdown, aberrant glial and immune activation, and progressive neuronal injury ...
Rongsu Huang, Linjie Wei, Mingxi Li, Bo Wu, Rongjian Ouyang, Gang Zhu, Yujie Chen   +6 more
wiley   +1 more source

Extracellular lactate improves neurogenesis by modulating H3K9 lactylation and SnoN expression under hypoxic conditions

Stem Cell Research & Therapy
Background Lactate has a beneficial effect on adult neurogenesis and has been identified as a mediator of lactylation of proteins. However, the regulatory role and function of histone lactylation in neurogenesis remain poorly understood. This study aimed
Wenhong Xu, Anqi Zhao, Rui Han, Junyuan Wei, Qi Yu, Miaomiao Wang, Haokun Li, Baofeng Xu, Meiying Li, Guangfan Chi   +9 more
doaj   +1 more source

Oxygen Glucose Deprivation-Induced Lactylation of H3K9 Contributes to M1 Polarization and Inflammation of Microglia Through TNF Pathway

Biomedicines
Background: Hypoxia-induced M1 polarization of microglia and resultant inflammation take part in the damage caused by hypoxic-ischemic encephalopathy (HIE).
Lu He, Rui Yin, Weijian Hang, Jinli Han, Juan Chen, Bin Wen, Ling Chen   +6 more
doaj   +1 more source