Results 101 to 110 of about 4,116 (175)

Histone and non-histone lactylation: molecular mechanisms, biological functions, diseases, and therapeutic targets

Molecular Biomedicine
Abstract Lysine lactylation (Kla) is a recently discovered post‑translational modification in which a lactyl moiety is transferred onto the ε‑amino group of lysine residues, linking cellular metabolism to epigenetic and signaling pathways. This process is regulated by a range of enzymes and metabolites, including lactate, “lactyltransferases (
Xia Peng, Juan Du
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Histone Lactylation Is Involved in Mouse Oocyte Maturation and Embryo Development

International Journal of Molecular Sciences
Numerous post-translational modifications are involved in oocyte maturation and embryo development. Recently, lactylation has emerged as a novel epigenetic modification implicated in the regulation of diverse cellular processes. However, it remains unclear whether lactylation occurs during oocyte maturation and embryo development processes. Herein, the
Diqi Yang, Haoyi Zheng, Wenjie Lu, Xueqi Tian, Yanyu Sun, Hui Peng   +5 more
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Lactylation of histone by BRD4 regulates astrocyte polarization after experimental subarachnoid hemorrhage

Journal of Neuroinflammation
Under subarachnoid hemorrhage (SAH) conditions, astrocytes undergo a marked intensification of glycolytic activity, resulting in the generation of substantial amounts of lactate to maintain the energy demand for neurons and other brain cells. Lactate has
Fan Zhang, Jian Zhou, Peng Lu, Xianhui Zhang, Lei Yang, Jinpeng Wu, Lihan Zhang, Lifang Zhang, Jinwei Pang, Huangfan Xie, Bingqing Xie, Yong Jiang, Jianhua Peng   +12 more
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Lipopolysaccharide-induced histone lactylation mediates m6A RNA modification causing mitochondrial dysfunction and pulmonary fibroblasts activation to exacerbate sepsis-associated pulmonary fibrosis

Respiratory Research
Background Histone lactylation and N6-methyladenosine (m6A) alteration are epigenetic modifications that have a crucial function in controlling gene expression throughout fibroblast activation and organ fibrosis. However, their roles in sepsis-associated
Ri Tang, Shaojie Qin, Qiaoyi Xu, Wenyu Lin, Shuyi Zhang, Yawen Peng, Jinhua Feng, Shunpeng Xing, Yuan Gao, Shuya Mei, Zhengyu He   +10 more
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Histone Lactylation Participates in Psoriasis Progression by Regulating the Adiponectin Expression

Clinical, Cosmetic and Investigational Dermatology
Psoriasis is a chronic inflammatory skin disease characterized by erythema, papules, and plaques. Adiponectin (ADIPOQ) is an important protein hormone secreted by adipose tissue. Here, we aimed to explore the expression of ADIPOQ in psoriasis patients and the moderation effect of histone lactylation on ADIPOQ.The GSE78097 data set was downloaded from ...
Zhao,Sicheng, Wu,Tingyan, Fu,Mingjing, Zhang,Zhe   +3 more
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Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation

Cell Reports
Summary: Macrophage activation is a hallmark of atherosclerosis, accompanied by a switch in core metabolism from oxidative phosphorylation to glycolysis.
Yunjia Zhang, Hong Jiang, Mengdie Dong, Jiao Min, Xian He, Yongkang Tan, Fuhao Liu, Minghong Chen, Xiang Chen, Quanwen Yin, Longbin Zheng, Yongfeng Shao, Xuesong Li, Hongshan Chen   +13 more
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Histone lactylation promotes malignant progression by facilitating USP39 expression to target PI3K/AKT/HIF-1α signal pathway in endometrial carcinoma

Cell Death Discovery
Histone lactylation has been reported to involve in tumorigenesis and development. However, its biological regulatory mechanism in endometrial carcinoma (EC) is yet to be reported in detail.
Sitian Wei, Jun Zhang, Rong Zhao, Rui Shi, Lanfen An, Zhicheng Yu, Qi Zhang, Jiarui Zhang, Yuwei Yao, Haojia Li, Hongbo Wang   +10 more
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The role of lactylation in tumor growth and cancer progression

Frontiers in Oncology
BackgroundLactate’s perception of lactate has changed over the last 30 years from a straightforward metabolic byproduct to a complex chemical with important biological activities, such as signal transduction, gluconeogenesis, and mitochondrial ...
Khulood Al-Malsi, Khulood Al-Malsi, Khulood Al-Malsi, Sinan Xie, Sinan Xie, Sinan Xie, Yunshi Cai, Yunshi Cai, Yunshi Cai, Nader Mohammed, Kunlin Xie, Kunlin Xie, Kunlin Xie, Tian Lan, Tian Lan, Tian Lan, Hong Wu, Hong Wu, Hong Wu   +18 more
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Lactylation as a metabolic-epigenetic switch in cancer: dual roles in cell death resistance and therapeutic vulnerability

Cell Death and Disease
Protein lactylation emerges as a pivotal metabolic rheostat, translating microenvironmental lactate flux into stable programs that orchestrate cancer treatment resistance. This review synthesizes recent advances under the framework of “Lactylation Switch
Chengjiao Yang, Ruici Yang, Binbin Zheng, Hongxiao Jiang, Xianteng Wang, Weiren Huang   +5 more
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Lactate metabolism and protein lactylation in cancer

Molecular Biomedicine
Lactylation is a recently identified post-translational modification that links cellular metabolism to gene regulation, playing pivotal roles in cancer development and the tumor microenvironment (TME).
Zhaoyun Liu, Aili Li, Ziyu Ma, Junzhu Wang, Xinyu Chen, Zhiwei Wang, Rong Fu   +6 more
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