Results 91 to 100 of about 4,358 (213)
Interdisciplinary Medicine, EarlyView.SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu +6 more
wiley +1 more source
KAT2A Promotes the Progression of Renal Cell Carcinoma by Regulating the Succinylation of SERPINE2
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Epithelial‐mesenchymal transition (EMT) and angiogenesis are critical drivers of renal cell carcinoma (RCC) progression, yet their upstream regulatory mechanisms remain incompletely understood. This study aimed to investigate the role of KAT2A in RCC and elucidate the underlying molecular mechanism by which it promotes tumor progression.
Chang‐Cheng Liu, Xue‐Dong Li
wiley +1 more source
Communications BiologyAcute ischemic stroke (AIS) triggers immune responses and neuroinflammation, contributing to brain injury. Histone lactylation, a metabolic stress-related histone modification, plays a critical role in various diseases, but its involvement in cerebral ...
Wei-Yue Si +11 more
doaj +1 more source
HeliyonRecent research emphasised the indispensable role of histone lactylation in the activation of hepatic stellate cells. The VHL mutation is extremely common in clear cell renal cell carcinoma, which normally causes a metabolic shift in cancer cells and ...
Weiyu Kong +13 more
doaj +1 more source
Lactate-induced histone lactylation by p300 promotes osteoblast differentiation [PDF]
昭和大学博士(歯学)2023年度doctoral ...
南, えりか
core
Beyond IDO1: Systems-Level Insights Into Enzymatic Networks And Regulatory Mechanisms In Cancer Immunotherapy Resistance [PDF]
Background: Cancer immunotherapy resistance affects 60-80% of patients receiving immune checkpoint inhibitors. The failure of IDO1 inhibitors in ECHO-301—despite achieving >90% target engagement—revealed critical gaps in understanding ...
Meera Indracanti, Muni Kumar Dokka, Madhumita Panda, Padmaja Musunuri, Nagendra Babu Gundamraju
core +2 more sources
Crosstalk Between Staphylococcus aureus and Innate Immunity: Focus on Immunometabolism [PDF]
, 2021 Staphylococcus aureus is a leading cause of bacterial infections globally in both healthcare and community settings. The success of this bacterium is the product of an expansive repertoire of virulence factors in combination with acquired antibiotic ...
Horn, Christopher M., Kielian, Tammy
core +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by a preclinical stage that typically lasts for decades. Early on during this time, microglia react to pathological changes and become protective and even transiently delay neurodegeneration.
Sara Merlo +3 more
wiley +1 more source
Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies
VIEW, EarlyView.This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li +5 more
wiley +1 more source
Lactate and lactylation: molecular insights into histone and non-histone lactylation in tumor progression, tumor immune microenvironment, and therapeutic strategies. [PDF]
Biomark ResAbstract Investigating cancer metabolism is of paramount importance for understanding tumor biology and developing novel therapeutic strategies. Lactylation, a posttranslational modification facilitated by the glycolytic product lactate, plays a crucial role in regulating oncogenic signalling pathways.
Xiao S +5 more
europepmc +3 more sources