Results 91 to 100 of about 4,116 (175)

Glycolysis‐Histone Lactylation Crosstalk Drives TXNIP‐NLRP3‐Mediated PANoptosome Assembly and PANoptosis Activation Underlying Diabetic Retinopathy Pathogenesis

MedComm
Diabetic retinopathy (DR), a major cause of vision loss in adults, involves aberrant metabolism and inflammation. This study investigated the interplay between glycolysis, histone lactylation, and PANoptosis in DR using human retinal pigment epithelial ...
Xiaoting Xi, Qianbo Chen, Jia Ma, Xuewei Wang, Yuxin Zhang, Qiuxia Xiong, Xiaolei Liu, Yuan Xia, Yan Li   +8 more
doaj   +1 more source

Lactylation: From Molecular Insights to Disease Relevance

Biomolecules
Lactylation, referring to the covalent coupling of the lactyl group with lysine residues, is a recently defined post-translational modification. It has been demonstrated that lactylation can alter protein transcription, thereby affecting the transmission
Yao Xu, Lu Zhang, Dong Shang, Hong Xiang
doaj   +1 more source

Amino acid homeostasis in the kidney: Physiological roles and pathological dysregulation

Physiological Reports, Volume 14, Issue 15, August 2026.
Abstract Amino acids are fundamental to life as protein building blocks and key regulators of metabolism and signaling. The kidney plays a critical, yet underappreciated, role in amino acid homeostasis through three interconnected pillars: selective glomerular filtration, efficient tubular reabsorption, and metabolic processing, which includes de novo ...
Shuo Liu, Caifeng Shi, Yang Zhou, Chunsun Dai   +3 more
wiley   +1 more source

Lactylation and human disease

Expert Reviews in Molecular Medicine
Background Lactylation, a new epigenetic modification, is an important way in which lactate exerts physiological functions. There is a close relationship between increased lactylations caused by lactate and glycolysis, which can interact and play a role ...
Linlin Wan, HuiJuan Zhang, Jialing Liu, Qian He, Jiumei Zhao, Chenglong Pan, Kepu Zheng, Yu Tang   +7 more
doaj   +1 more source

New insights into the roles of lactylation in cancer

Frontiers in Pharmacology
Lactylation, a novel discovered posttranslational modification, is a vital component of lactate function and is prevalent in a wide range of cells, interacting with both histone and non-histone proteins.
Yajun Zhu, Yajun Zhu, Wenhui Liu, Wenhui Liu, Zhiying Luo, Zhiying Luo, Feiyan Xiao, Bao Sun, Bao Sun   +8 more
doaj   +1 more source

Virus‐Induced Histone Lactylation Promotes Virus Infection in Crustacean

Advanced Science
AbstractAs “non‐cellular organisms”, viruses need to infect living cells to survive themselves. The virus infection must alter host's metabolisms. However, the influence of the metabolites from the altered metabolisms of virus‐infected host cells on virus‐host interactions remains largely unclear. To address this issue, shrimp, a representative species
Yu Zhang, Xiaobo Zhang
openaire   +3 more sources

Lactylation in tissue fibrosis: epigenetic mechanisms, metabolic crosstalk, and therapeutic opportunities

Journal of Translational Medicine
Background Tissue fibrosis, driven by chronic inflammation and degeneration, leads to progressive organ dysfunction. While significant advancements have been made, effective therapies remain limited.
Zhe Qiu, Yifan Zhang, Xiaoyan Li, Zhibo Xie   +3 more
doaj   +1 more source

Lactylation in cardiac repair: Nexus and therapeutic opportunity

Journal of Molecular and Cellular Cardiology Plus
Lactylation is a lactate-driven post-translational modification that directly modifies lysine residues on both histone and non-histone proteins, thereby linking energy metabolism to epigenetic regulation.
Fan Guo, Lingmei Li, Shujuan Xu, Lanlan Li, Yuanyuan Chen, Jiaming Gao, Zixin Liu, Jingjing Zhao, Yehao Zhang, Jianhua Fu   +9 more
doaj   +1 more source

Histone lactylation [PDF]

Nature Immunology, 2019
openaire   +2 more sources

Histone lactylation drives METTL3 upregulation-mediated RNA m6A modification of CCT2 to hinder CD8+ T cell survival in gastric cancer

Cellular and Molecular Life Sciences
Background Histone lactylation represents a novel epigenetic modification that can modulate gene expression, further boosting tumor proliferation, metastasis, and immune suppression.
Zhenyuan Qian, Xufan Cai, Fang Wu, Zaiyuan Ye, Jianzhang Wu   +4 more
doaj   +1 more source