Results 121 to 130 of about 4,358 (213)

New insights into the roles of lactylation in cancer

Frontiers in Pharmacology
Lactylation, a novel discovered posttranslational modification, is a vital component of lactate function and is prevalent in a wide range of cells, interacting with both histone and non-histone proteins.
Yajun Zhu, Yajun Zhu, Wenhui Liu, Wenhui Liu, Zhiying Luo, Zhiying Luo, Feiyan Xiao, Bao Sun, Bao Sun   +8 more
doaj   +1 more source

Lactate-induced lactylation: from basic research to clinical perspectives [PDF]

Lactate was initially considered a metabolic waste product of glycolysis under hypoxic conditions until the emergence of the lactate shuttle hypothesis.
Bin Liu, Henghe Shi, Junduo Wu, Sijie Jin, Yifei Zou   +4 more
core   +1 more source

Identification and Screening of Lactate‐Related Genes as Molecular Markers for Early Diagnosis of Steroid‐Induced Osteonecrosis of the Femoral Head

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Identification and validation of lactate‐related genes biomarkers for steroid‐induced osteonecrosis of the femoral head through integrated bioinformatics analysis, machine learning, and experimental verification. ABSTRACT Steroid‐induced osteonecrosis of the femoral head (SONFH) is a major cause of disability among young and middle‐aged adults. However,
Zehua Wang, Shuhang Dong, Kaige Xu, Xinyu Tang, Sijia Guo, Yaping Jiang, Yingze Zhang, Tao Li   +7 more
wiley   +1 more source

Lactylation and human disease

Expert Reviews in Molecular Medicine
Background Lactylation, a new epigenetic modification, is an important way in which lactate exerts physiological functions. There is a close relationship between increased lactylations caused by lactate and glycolysis, which can interact and play a role ...
Linlin Wan, HuiJuan Zhang, Jialing Liu, Qian He, Jiumei Zhao, Chenglong Pan, Kepu Zheng, Yu Tang   +7 more
doaj   +1 more source

Obesity Disrupts H3K4me3‐Mediated Lactate Accumulation and Efferocytosis in Hypoxic Macrophages

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Obesity disrupts macrophage adaptation to hypoxic microenvironments. In lean conditions, hypoxia induces H3K4me3‐dependent transcriptional programs that promote lactate accumulation, histone lactylation, and efficient efferocytosis. Diet‐induced obesity impairs this epigenetic–metabolic response, resulting in reduced lactate accumulation, defective ...
Kentaro Takahashi, Julia Drolet, Jinghua Liu, Jasmine R. Jackson, Madison Babcock, Muthusamy Thiruppathi, Milie Fang, Tyler Paul, Gayathri Ganesh, Yuri Fukasawa, Yoshikiyo Akasaka, Giamila Fantuzzi, Elizaveta V. Benevolenskaya, Timothy J. Koh, Norifumi Urao   +14 more
wiley   +1 more source

Glycolysis‐Histone Lactylation Crosstalk Drives TXNIP‐NLRP3‐Mediated PANoptosome Assembly and PANoptosis Activation Underlying Diabetic Retinopathy Pathogenesis

MedComm
Diabetic retinopathy (DR), a major cause of vision loss in adults, involves aberrant metabolism and inflammation. This study investigated the interplay between glycolysis, histone lactylation, and PANoptosis in DR using human retinal pigment epithelial ...
Xiaoting Xi, Qianbo Chen, Jia Ma, Xuewei Wang, Yuxin Zhang, Qiuxia Xiong, Xiaolei Liu, Yuan Xia, Yan Li   +8 more
doaj   +1 more source

DNAJC12 downregulation induces neuroblastoma progression via increased histone H4K5 lactylation

Journal of Molecular Cell Biology
Abstract Neuroblastoma (NB) is the most common extracranial solid tumor in children. Despite treatment advances, the survival rates of high-risk NB patients remain low. This highlights the urgent need for a deeper understanding of the molecular mechanisms driving NB progression to support the development of new therapeutic strategies. In
Yaqi Yang, Jiejun Wen, Susu Lou, Yali Han, Yi Pan, Ying Zhong, Qiao He, Yinfeng Zhang, Xi Mo, Jing Ma, Nan Shen   +10 more
openaire   +2 more sources

Histone lactylation drives METTL3 upregulation-mediated RNA m6A modification of CCT2 to hinder CD8+ T cell survival in gastric cancer

Cellular and Molecular Life Sciences
Background Histone lactylation represents a novel epigenetic modification that can modulate gene expression, further boosting tumor proliferation, metastasis, and immune suppression.
Zhenyuan Qian, Xufan Cai, Fang Wu, Zaiyuan Ye, Jianzhang Wu   +4 more
doaj   +1 more source

Lactylation: The emerging frontier in post-translational modification [PDF]

Lactate, a metabolic byproduct, has gained recognition as a highly influential signaling molecule. Lactylation, an emerging form of post-translational modification derived from lactate, plays a crucial role in numerous cellular processes such as ...
Chenghe Ding, Mingsong Shi, Xiaoan Li, Xiaoan Li, Xueting Zheng, Yan Zhou, Yuan Yin, Yuanjing He, Yuanyuan Liang, Zhiyan Zou, Zhou Lu   +10 more
core   +1 more source

Lactylation in diabetes mellitus and its complications: mechanisms of action and therapeutic potential - recent advances [PDF]

BackgroundDiabetes mellitus (DM) and its complications represent a global health burden. Lactylation, a novel post-translational modification (PTM) linking metabolism to epigenetic regulation, has emerged as a key mediator in metabolic disorders ...
Lan Liu, Min Zhou, Xiaoshu Wang, Yihong Sun   +3 more
core   +1 more source