Results 121 to 130 of about 128,524 (232)

Lactylation and human disease

Expert Reviews in Molecular Medicine
Background Lactylation, a new epigenetic modification, is an important way in which lactate exerts physiological functions. There is a close relationship between increased lactylations caused by lactate and glycolysis, which can interact and play a role ...
Linlin Wan, HuiJuan Zhang, Jialing Liu, Qian He, Jiumei Zhao, Chenglong Pan, Kepu Zheng, Yu Tang   +7 more
doaj   +1 more source

Fluvastatin Plus Dipyridamole Suppresses Canine Hemangiosarcoma Growth in Patient‐Derived Xenograft Models Through Lactate Dehydrogenase‐Associated Cholesterol/Lipid Metabolism

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Tumour cells commonly exhibit aerobic glycolysis and produce lactate despite oxygen availability. Lactate dehydrogenase (LDH) catalyses pyruvate‐lactate interconversion and regulates intracellular lactate levels. Endothelial cells also depend on glycolysis for ATP production, which prompted us to investigate LDH in canine hemangiosarcoma (HSA),
Tamami Suzuki, Suzune Tanaka, Keika Kishimoto, Takuma Goto, Jumpei Yamazaki, Takashi Kimura, Keisuke Aoshima   +6 more
wiley   +1 more source

Lactylation in tissue fibrosis: epigenetic mechanisms, metabolic crosstalk, and therapeutic opportunities

Journal of Translational Medicine
Background Tissue fibrosis, driven by chronic inflammation and degeneration, leads to progressive organ dysfunction. While significant advancements have been made, effective therapies remain limited.
Zhe Qiu, Yifan Zhang, Xiaoyan Li, Zhibo Xie   +3 more
doaj   +1 more source

New insights into the roles of lactylation in cancer

Frontiers in Pharmacology
Lactylation, a novel discovered posttranslational modification, is a vital component of lactate function and is prevalent in a wide range of cells, interacting with both histone and non-histone proteins.
Yajun Zhu, Yajun Zhu, Wenhui Liu, Wenhui Liu, Zhiying Luo, Zhiying Luo, Feiyan Xiao, Bao Sun, Bao Sun   +8 more
doaj   +1 more source

Lactylation Modification and Esophageal Cancer: Research Progress From Hypoxia‐Induced Metabolic Reprogramming to Immune Escape

Esophageal cancer is a common malignancy of the digestive tract, marked by aggressive invasion, unfavorable prognosis, and limited responsiveness to existing therapeutic strategies.
Weizhuang Sun, Xiaowei Liu, Yang Wang, Changyong Li   +3 more
core   +1 more source

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Lactate metabolism and protein lactylation in inflammatory and tumor microenvironments

Molecular Biomedicine
Lactate and lactate-mediated protein lactylation are no longer viewed merely as accompanying phenomena of enhanced glycolysis, hypoxic responses, or tissue acidification.
Huaqing Lei, Yulin Bai, Jiaqi Tang, Xiaoyan Pu, Jiarui Lan, Xiangyu Lei, Dan Cai, Shuang Gou, Lin Liu, Siyu Hao, Yu Chen, Yueshui Zhao, Jing Shen, Xu Wu, Mingxing Li, Meijuan Chen, Xiaobing Li, Yuhong Sun, Li Gu, Wanping Li, Zhangang Xiao, Yan Li, Yan Zhang, Hanyu Li, Fukuan Du   +24 more
doaj   +1 more source

Lactylation in cardiac repair: Nexus and therapeutic opportunity

Journal of Molecular and Cellular Cardiology Plus
Lactylation is a lactate-driven post-translational modification that directly modifies lysine residues on both histone and non-histone proteins, thereby linking energy metabolism to epigenetic regulation.
Fan Guo, Lingmei Li, Shujuan Xu, Lanlan Li, Yuanyuan Chen, Jiaming Gao, Zixin Liu, Jingjing Zhao, Yehao Zhang, Jianhua Fu   +9 more
doaj   +1 more source

Warburg redefined: Metabolites, mitochondria and macrophages in immune regulation

The Journal of Physiology, EarlyView.
Abstract figure legend Following pro‐inflammatory stimulation, macrophages undergo Warburg‐like metabolic rewiring that extends more than increased glycolysis. The non‐canonical functions of glycolytic enzymes and lactate accumulation control macrophage immune responses through multiple signalling pathways (a).
Yukun Min, Órlaith C. Henry, Luke A. J. O'Neill   +2 more
wiley   +1 more source

Histone lactylation drives METTL3 upregulation-mediated RNA m6A modification of CCT2 to hinder CD8+ T cell survival in gastric cancer

Cellular and Molecular Life Sciences
Background Histone lactylation represents a novel epigenetic modification that can modulate gene expression, further boosting tumor proliferation, metastasis, and immune suppression.
Zhenyuan Qian, Xufan Cai, Fang Wu, Zaiyuan Ye, Jianzhang Wu   +4 more
doaj   +1 more source