Results 141 to 150 of about 4,358 (213)

Histone lactylation couples cellular metabolism with developmental gene regulatory networks

Nature Communications
AbstractEmbryonic cells exhibit diverse metabolic states. Recent studies have demonstrated that metabolic reprogramming drives changes in cell identity by affecting gene expression. However, the connection between cellular metabolism and gene expression remains poorly understood.
Fjodor Merkuri, Megan Rothstein, Marcos Simoes-Costa   +2 more
openaire   +3 more sources

Lactate metabolism and protein lactylation in cancer

Molecular Biomedicine
Lactylation is a recently identified post-translational modification that links cellular metabolism to gene regulation, playing pivotal roles in cancer development and the tumor microenvironment (TME).
Zhaoyun Liu, Aili Li, Ziyu Ma, Junzhu Wang, Xinyu Chen, Zhiwei Wang, Rong Fu   +6 more
doaj   +1 more source

Histone lactylation-driven B7-H3 expression promotes tumor immune evasion

Theranostics
Rationale: Tumor cells possess sophisticated strategies to circumvent immune detection, including the modulation of endogenous immune checkpoints, particularly those within the B7 family. Elucidating the mechanisms that govern the induction of B7 family molecules is crucial for the advancement of immunotherapy.
Ma, Zhibo, Yang, Jincui, Jia, Wenlong, Li, Le, Li, Yixin, Hu, Junjie, Luo, Wei, Li, Ronghui, Ye, Dawei, Lan, Peixiang   +9 more
openaire   +2 more sources

Dux activates metabolism-lactylation-MET network during early iPSC reprogramming with Brg1 as the histone lactylation reader

Nucleic Acids Research
Abstract The process of induced pluripotent stem cells (iPSCs) reprogramming involves several crucial events, including the mesenchymal-epithelial transition (MET), activation of pluripotent genes, metabolic reprogramming, and epigenetic rewiring.
Xinglin Hu, Xingwei Huang, Yue Yang, Yuchen Sun, Yanhua Zhao, Zhijing Zhang, Dan Qiu, Yanshuang Wu, Guangming Wu, Lei Lei   +9 more
openaire   +2 more sources

Histone lactylation mediated by Fam172a in POMC neurons regulates energy balance

Nature Communications
Glycolysis-derived lactate was identified as substrate for histone lactylation, which has been regarded as a significant role in transcriptional regulation in many tissues. However, the role of histone lactylation in the metabolic center, the hypothalamus, is still unknown.
Zhuo Chen, Baocheng Wan, Hong Zhang, Lina Zhang, Rong Zhang, Lianxi Li, Yi Zhang, Cheng Hu   +7 more
openaire   +3 more sources

H3K14 lactylation exacerbates neuronal ferroptosis by inhibiting calcium efflux following intracerebral hemorrhagic stroke

Cell Death and Disease
Inhibiting neuronal ferroptosis is essential for mitigating neural damage and enhancing recovery in central nervous system (CNS) disorders, including intracerebral hemorrhagic stroke (ICH).
Tingting Sun, Jian-Nan Zhang, Ting Lan, Lei Shi, Liye Hu, Liyan Yan, Chao Wei, Lisha Hei, Weihua Wu, Zhaoli Luo, Meng Liu, Xingmei Ren, Yamei Wang, Yabin Lu, Peipei Wang, Chenguang Zhang, Liheng Bian, Xingquan Zhao, Fei Yang, Qian Li   +19 more
doaj   +1 more source

Epigenetic Changes Associated With Obesity-related Metabolic Comorbidities [PDF]

Obesity arises from a complex interaction of genetic, hormonal, dietary, and behavioral factors that drive chronic energy imbalance, excessive fat accumulation, systemic inflammation, and insulin resistance, thus increasing the risk of metabolic diseases.

core   +1 more source

ACSS2: Tumor-promoting lactyl-CoA synthetase that drives histone lactylation

hLife
Katherine L. Wang, Zhongsheng You
openaire   +2 more sources

Innate Immunity Champions: The Diverse Functions of Macrophages [PDF]

Macrophages are instrumental in maintaining tissue homeostasis, modulating inflammation and driving regeneration. The advent of omics techniques has led to the identification of numerous tissue-specific macrophage subtypes, thereby introducing the ...
Biscu, Francesca, Cicia, Donatella, Matteoli, Gianluca, Pridans, Clare, Zouzaf, Anissa   +4 more
core  

Histone lactylation modification and its role in cerebral ischemia-reperfusion injury (Review). [PDF]

Biomed Rep
Tao J, Xu J, Zhou L.
europepmc   +1 more source