Results 151 to 160 of about 128,524 (232)

T‐Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This Review presents renal fibrosis as a sequence of overlapping T‐cell programs, from chemokine‐guided recruitment and metabolic activation to maladaptive polarization, tertiary lymphoid structure formation, tissue residency, exhaustion, and senescence.
Qianhui Li, Junting Guan, Yifan Song, Hongxia Yang, Guangtao Li, Xiaodong Zhao, Jiaxin Liu, Bin Liu, Yang Tan, Honglan Zhou, Yang‐He Zhang, Yishu Wang   +11 more
wiley   +1 more source

Recapitulating hypoxic metabolism in cartilaginous organoids via adaptive cell-matrix interactions enhances histone lactylation and cartilage regeneration

Mesenchymal condensation, characterized by rapid proliferation and aggregation of precursor cells within a restructured mesodermal extracellular matrix, is critical for skeletal tissue development, including articular cartilage.
Lyu, Yuanning, Bian, Liming, Liu, Wei, Li, Gang, Yang, Zhengmeng, Yang, Xuefeng, Zhao, Pengchao, Zong, Zhixian, Yang, Zhinan, Ngai, To, Li, Zhuo, Yang, Boguang, Wu, Jiahao, Zhang, Kunyu, Lin, Sien, Xie, Xian   +15 more
core   +1 more source

Spatiotemporal heterogeneity and dynamic evolution of microglial glucose metabolic reprogramming in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract Alzheimer's disease (AD) is accompanied by persistent disturbances in brain energy metabolism, and microglial glucose metabolic reprogramming constitutes an important link among pathological protein deposition, neuroinflammation, and impaired clearance.
Yuan Chen, Fuyao Li, Junlei Zhang, Mingqing Wei, Jingnian Ni, Ting Li, Lulu Yao, Jinzhou Tian, Jing Shi   +8 more
wiley   +1 more source

Lactate-driven histone lactylation by AARS1 promotes pulmonary arterial hypertension. [PDF]

iScience
Chen Z, Cai Z, Lin Y, Chen A, Cao R, Yu L, Cai K, Lian G, Xie L.   +8 more
europepmc   +1 more source

METTL3 Increases Temozolomide Resistance in MGMT‐Negative Glioblastoma by Enhancing CBX5 mRNA Stability in an m6A‐IGF2BP2‐Dependent Manner

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
METTL3‐dependent m6A modification and IGF2BP2‐associated CBX5 mRNA stabilization help maintain CBX5 expression in MGMT‐negative glioblastoma. During temozolomide (TMZ) treatment, CBX5 contributes to ATM–RAD51‐associated signaling, limits persistent DNA damage and apoptosis, and thereby supports cell survival and TMZ resistance.
Hui Deng, Ruoyu Chen, Daohong Qu, Cifu Qu, Jia Shi   +4 more
wiley   +1 more source

Acetylation‐like H2BK109Q attenuates acute brain injury and preserves axon‐myelin integrity after intracerebral hemorrhage

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
After intracerebral hemorrhage, reduced pan‐H2B acetylation is linked to acute brain injury and axon–myelin damage. The acetylation‐mimetic H2BK109Q substitution attenuates injury and preserves axon–myelin integrity. Regional Galc knockdown diminishes this protection, identifying GALC as a primary contributing effector. ABSTRACT Aims Axon–myelin damage
Sinan Jin, Meng Yang, Jincheng Meng, Ziyi Han, Yousef Rastegar‐Kashkooli, Pengtian Lu, Junmin Wang, Jian Wang, He Wu   +8 more
wiley   +1 more source

Histone lactylation-mediated glycolysis-ferroptosis axis in neurological diseases. [PDF]

Front Mol Neurosci
Wei Z, Bai L, Liu X, Zhou Y, Zheng L, Zhang B, Wang L, Zou W.   +7 more
europepmc   +1 more source

ATF3 Promotes Solasonine‐Triggered Ferroptosis in Glioma Cells by Suppressing Glycolysis

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Solasonine inhibits glycolysis by increasing ATF3 expression, thereby increasing hydrogen peroxide levels, promoting ferritinophagy and lipid peroxidation, leading to ferroptosis. Furthermore, hydrogen peroxide activates endoplasmic reticulum stress, promoting ATF3 expression, and the whole process forms a positive feedback loop.
Mingbo Jia, Hexin Xiao, Minghao Shi, Yao Li, Yang Yang, Jianing Zhao, Zhuoyue Shan, Pengfei Ge, Liyan Zhao   +8 more
wiley   +1 more source

Salvianolic Acid B Alleviates Liver Injury by Regulating Lactate-Mediated Histone Lactylation in Macrophages

Salvianolic acid B (Sal B) is the primary water-soluble bioactive constituent derived from the roots of Salvia miltiorrhiza Bunge. This research was designed to reveal the potential mechanism of Sal B anti-liver injury from the perspective of macrophages.
Shian Hu, Yutong Hu, Ling Li, Feng Zhou, Yang Tan, Gang Pei, Qinwen Yan, Zehua Yang   +7 more
core   +1 more source

Publisher Correction: IRF7 links HK1-dependent histone lactylation to fibroblast activation and cardiac fibrosis. [PDF]

EMBO Mol Med
Kong M, Zhu C, Xue Y, Hong W, Zhang G, Jiang D, Xu Y, Guo J.   +7 more
europepmc   +1 more source