Results 171 to 180 of about 128,524 (232)

Ischemic Stroke and Traumatic Brain Injury: Epidemiology, Molecular Pathways, and Emerging Therapies

MedComm, Volume 7, Issue 10, October 2026.
Schematic overview of secondary brain injury after ischemic stroke and traumatic brain injury. Both conditions trigger endothelial cell dysfunction, pericyte contraction, and upregulated AQP4 expression in astrocytic end‐feet, leading to blood–brain barrier disruption.
Mengzhao Feng, Qi Qin, Fang Wang, Kaiyuan Zhang, Zhihua Li, Junlei Chang, Min Yu, Fuyou Guo   +7 more
wiley   +1 more source

Role of CircRNA_0005075 in gastric cancer immune evasion through regulation of lactate metabolic reprogramming and histone lactylation. [PDF]

Transl Oncol
Wu J, Jiang J, Chen C, Dou G, Huang L, Zhu Y, Shen X, Chen J.   +7 more
europepmc   +1 more source

WTAP Histone Lactylation Drives the YTHDF1/ALOX15 Axis to Regulate Ferroptosis in Myocardial Ischemia-Reperfusion Injury. [PDF]

FASEB J
Liu W, Wang Y, Wu J, He C, Zhou Z.
europepmc   +1 more source

An Acidic Tubulointerstitial Microenvironment Delays Cell‐Cycle Progression in Proximal Tubule Cells and Fibroblasts and Synergizes With Lactate to Drive Phenotypic Alterations

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Background Chronic kidney disease (CKD) is characterized by progressive tubulointerstitial inflammation and fibrosis, particularly affecting the proximal tubule. Both proximal tubular epithelial cells and interstitial fibroblasts contribute to CKD progression through cell‐cycle arrest and phenotypic transitions.
Marie‐Christin Schulz, Virginie Dubourg, Lea Schaude, Natalie Schröder, Eva Janßen, Isabelle Görlich, Stefanie Ruhs, Michael Kopf, Michael Gekle   +8 more
wiley   +1 more source

Epigenetic pacemaker: A review of DNA methylation, histone lactylation, and non-coding RNAs in autoimmune skin diseases. [PDF]

J Transl Autoimmun
Chen J, Feng X, Li Y, Zheng B.
europepmc   +1 more source

Sodium Butyrate Attenuates Renal Fibrosis by Regulating Glycolysis and Histone H4K12 Lactylation in Diabetic Kidney Disease

Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 9518-9534, October 2026.
ABSTRACT Background The role of histone lactylation in diabetes associated renal fibrosis remains poorly defined. In this study, we investigated the contribution of histone H4 lysine 12 lactylation (H4K12la) to abnormal glycolysis and renal fibrogenesis in diabetic kidney disease (DKD) and evaluated sodium butyrate (NaB) as a potential therapeutic ...
Ping He, Mingxiu Wang, Hang Mei, Yue Liu, Min Wang, He Sun, Yali Peng, Xuan Ban, Yue Wang, Xiaofang Tang, Qiuling Fan   +10 more
wiley   +1 more source

IRF7 links HK1-dependent histone lactylation to fibroblast activation and cardiac fibrosis. [PDF]

EMBO Mol Med
Kong M, Zhu C, Xue Y, Hong W, Zhang G, Jiang D, Xu Y, Guo J.   +7 more
europepmc   +1 more source

Mechanisms and therapeutic implications of metabolic heterogeneity and histone lactylation in clear cell renal cell carcinoma. [PDF]

Discov Oncol
Ma J, Qiang Z, Xie W, Jiao L, Wang Y, Mi L, Yang Z, Chen G.   +7 more
europepmc   +1 more source

Metabolic-epigenetic crosstalk in latent autoimmune diabetes in adults: potential roles of lactate-induced histone lactylation in immune regulation and pancreatic β-cell fate. [PDF]

Front Endocrinol (Lausanne)
Zhang W, Wang X, He B, Xia Y, Cao Z, Xu S.   +5 more
europepmc   +1 more source

Histone lactylation boosted SET8 potentiates carcinogenesis and angiogenesis of pancreatic ductal adenocarcinoma by cooperating with MTA1/NuRD complex. [PDF]

J Transl Med
Liu X, Tuergong A, Wang M, Shi W, Tian X, Ting X, Cui L, Si W.   +7 more
europepmc   +1 more source