Results 181 to 190 of about 4,358 (213)

Exploration of biomarkers associated with histone lactylation modification in spinal cord injury. [PDF]

Front Genet
Sun Y, Gao J, Jing J.
europepmc   +1 more source

Histone lactylation-induced GLI3 activation drives macrophage M1 polarization and exosomal SERPINE1 release in abdominal aortic aneurysm progression. [PDF]

Cell Death Discov
Yuan K, Liu J, Chen G, Wang P, Wei L.
europepmc   +1 more source

Hypoxia-Induced Histone Lactylation Drives Cisplatin Resistance in Bladder Cancer by Promoting RBM15-Dependent m⁶A Methylation of IGFBP3. [PDF]

Research (Wash D C)
Sun J, Shi Y, Yu K, Huang S, Lu D, Niu X, Li Y, Wang F, Ma X, Li J, Liu X, Xie L, Huang H, Liu B.   +13 more
europepmc   +1 more source

PFKM-Driven Lactate Overproduction Promotes Atrial Fibrillation via Triggering Cardiac Fibroblasts Histone Lactylation. [PDF]

Adv Sci (Weinh)
Fang N, Zhang N, Jiang X, Yan S, Wang Z, Gao Q, Xu M, Mu L, Li X, Chen J, Zhang S, Duan Y, Yun F, Li L, Zhang Y, Gong Y.   +15 more
europepmc   +1 more source

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Histone Lactylation Boosts Reparative Gene Activation Post–Myocardial Infarction

Circulation Research, 2022
Background: Inflammation resolution and cardiac repair initiation after myocardial infarction (MI) require timely activation of reparative signals. Histone lactylation confers macrophage homeostatic gene expression signatures via transcriptional regulation.
Naixin Wang, Ping Sun, Maomao Zhang
exaly   +3 more sources

Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis

Cell Metabolism
Histone lysine lactylation is a physiologically and pathologically relevant epigenetic pathway that can be stimulated by the Warburg effect-associated L-lactate. Nevertheless, the mechanism by which cells use L-lactate to generate lactyl-coenzyme A (CoA) and how this process is regulated remains unknown.
Hening Lin, Yingming Zhao
exaly   +3 more sources

Augmentation of scleral glycolysis promotes myopia through histone lactylation

Cell Metabolism
Myopia is characterized of maladaptive increases in scleral fibroblast-to-myofibroblast transdifferentiation (FMT). Scleral hypoxia is a significant factor contributing to myopia, but how hypoxia induces myopia is poorly understood. Here, we showed that myopia in mice and guinea pigs was associated with hypoxia-induced increases in key glycolytic ...
Xiangtian Zhou, Fei Zhao
exaly   +3 more sources

Histone lactylation drives CD8+ T cell metabolism and function

Nature Immunology
The activation and functional differentiation of CD8+ T cells are linked to metabolic pathways that result in the production of lactate. Lactylation is a lactate-derived histone post-translational modification; however, the relevance of histone lactylation in the context of CD8+ T cell activation and function is not known.
Pratishtha Singh, Sangeeta Goswami
exaly   +3 more sources

Lactate, histone lactylation and cancer hallmarks

Expert Reviews in Molecular Medicine, 2023
Abstract Histone lactylation, an indicator of lactate level and glycolysis, has intrinsic connections with cell metabolism that represents a novel epigenetic code affecting the fate of cells including carcinogenesis. Through delineating the relationship between histone lactylation and cancer hallmarks, we propose histone lactylation as a novel ...
Xinyu Lv, Yingying Lv, Xiaofeng Dai
openaire   +2 more sources

LDHA promotes osteoblast differentiation through histone lactylation

Biochemical and Biophysical Research Communications, 2022
Osteoblast cells tend to metabolize glucose to lactate via aerobic glycolysis during osteogenic differentiation. However, the function of lactate in this process is still elusive. As a newly discovered protein posttranslational modification, lactate-derived histone lactylation has been found to play important roles in gene regulation and have profound ...
Feige, Nian, Yezhou, Qian, Fangyan, Xu, Mingfeng, Yang, Hongzhi, Wang, Zhufeng, Zhang   +5 more
openaire   +2 more sources