Results 161 to 170 of about 128,524 (232)

MPC-mediated lactate production drives histone lactylation in dendritic cells to affect tumor progression and immunotherapy

Lactate is an abundant oncometabolite in the tumor microenvironment (TME). Lactate driven by metabolic reprogramming leads to acidic microenvironment formation to promote the immune evasion of tumor cells and reduce the effectiveness of immunotherapy for
Anran Xu, Haowei Wang, Shuang Wang, Qing Zhang, Bin Zhang, Wei Yan   +5 more
core   +1 more source

Multi‐omics integration and machine learning identify an ACKR1+ endothelial cell‐based lactate‐immune signature associated with carotid plaque vulnerability and progression

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
ACKR1+ endothelial cells mark intraplaque neovessels with hyperactive glycolysis and lactate metabolism. Lactate, HIF‐1α and CXCL12 link this state to CXCR4+ CD8+ T‐cell recruitment in situ. SLC16A3 and SLC16A4 serve as quantitative readouts of this lactate–immune state.
Ji Zhang, Qijian Zhao, Yufei Wu, Keqiang Shu, Junye Chen, Kang Li, Yuyao Feng, Xu Zhang, Wenjian Liu, Zhichao Lai, Bao Liu   +10 more
wiley   +1 more source

Exosomal lactate dehydrogenase A and histone lactylation: Redefining the metabolic language of cytopathology. [PDF]

Cytojournal
Ngoc Dang HN, Luong TV, Tran TN.
europepmc   +1 more source

The Sleeping Giant: Metabolism and Autophagy in the Generation and Survival of Dormant Polyploid Giant Cancer Cells

MedComm, Volume 7, Issue 10, October 2026.
Polyploid giant cancer cells (PGCCs) arise in response to stress and play a critical role in therapy resistance and tumor dormancy. These cells can evade conventional treatments and later contribute to cancer relapse by generating progeny through nonmitotic, amitotic mechanisms.
Silvia Guil‐Luna, María Teresa Sánchez‐Montero, Alejandra Díaz‐Chacón, Antonio Rodríguez‐Ariza   +3 more
wiley   +1 more source

OLFM4 promotes intrahepatic cholangiocarcinoma progression through a PKM2-glycolysis-histone lactylation feedback loop. [PDF]

Int J Biol Sci
Liu S, Cao K, Chen C, Xu X, Shan J, Li C, Chen R, Chen Y, Chang J, Jiang W, Zhang Y, Wang D, Li C, Li X.   +13 more
europepmc   +1 more source

Cytoskeletal Dynamics in Cancer: From Pathogenesis to Treatment

MedComm, Volume 7, Issue 10, October 2026.
This review systematically addresses the fundamental roles of the cytoskeleton (actin filaments, microtubules, and intermediate filaments) in cancer progression. We focus on how cytoskeletal dynamics regulate tumor proliferation, metastasis, and programmed cell death, while also modulating the immune microenvironment. Understanding these mechanisms may
Jie Chen, Wenxi Yang, Yonghan Song, Yuanhao Zhang, Jia Ma, Tingyao Wang, Jijun Zheng, Hebin Zhang, Yiyao Liu, Jinhao Zeng   +9 more
wiley   +1 more source

Cancer Cell Metastasis: From Molecular Mechanisms to Therapeutic Strategies

MedComm, Volume 7, Issue 10, October 2026.
The schematic representation of intrinsic and extrinsic influences of cancer cell metastasis. Genomic evolution of metastatic tumor cells (MTCs) promotes their metastatic phenotypes and reconstruct the primary tumor microenvironment. During MTCs migration along different routes (blood circulation, lymphatic vessels, and perineuronal spaces), the ...
Yupeng Zhao, Wenchao Xu, Yibo Wang, Haoran Huang, Yu Su, Li Zhou, Jianzhou Liu, Junchao Guo   +7 more
wiley   +1 more source

ACSS2: Tumor-promoting lactyl-CoA synthetase that drives histone lactylation

hLife
Katherine L. Wang, Zhongsheng You
openaire   +2 more sources

Immune‐Cell Dynamics in the Tumor Microenvironment: Implications for Cancer Therapy

MedComm, Volume 7, Issue 10, October 2026.
Immune‐cell dynamics in the tumor microenvironment converge on four major barriers to effective therapy: failed immune access, defective antigen visibility and priming, loss of effector maintenance, and suppressive tissue remodeling. These barriers emerge from local hypoxic, cytokine, metabolic, and stromal signals.
Pin Guo, Yizhao Xie, Rui Song, Mengdi Yang, Zhen Lin, Chao Guan, Zechen Wang, Jin Wen, Guang‐Liang Chen   +8 more
wiley   +1 more source

The Biological Actions and Regulations of Lactic Acid-Linked Histone Lactylation. [PDF]

Biology (Basel)
Zhu Y, Li K, Wang Y, Li Y, Zhu C, Zhu C, Yuan L, Hu P, Liu H, Cai D.   +9 more
europepmc   +1 more source