Results 161 to 170 of about 4,116 (175)

Efficient synthesis of lactylated histone peptides enabled by a pre-prepared protected lactylated-lysine

Tetrahedron Letters, 2023
Qingyao Shu, Jian Fan, Bingji Wang, Jing Shi   +3 more
openaire   +1 more source

Histone lactylation: A sensor of epigenetic reprogramming mediated by cellular metabolism

Cellular Signalling
Epigenetic reprogramming plays a critical role in connecting genotype to phenotype, providing the flexibility that allows organisms to adapt to developmental needs, environmental shifts, and disease challenges through the flexible regulation of gene expression.
Lei, Wang, Shuaifei, Song, Shiyi, Yao, Zihan, Wang, Qiuyan, Li, Zihan, Ma, Jiayue, Li, Yaru, Li, Mingzhi, Yang, Ke, Zhang, Yanguo, Han, Dejun, Xu, Zhongquan, Zhao   +12 more
openaire   +2 more sources

Histone lactylation drives CD8+ T cell metabolism and function

Nature Immunology
The activation and functional differentiation of CD8+ T cells are linked to metabolic pathways that result in the production of lactate. Lactylation is a lactate-derived histone post-translational modification; however, the relevance of histone lactylation in the context of CD8+ T cell activation and function is not known.
Deblina Raychaudhuri, Pratishtha Singh, Bidisha Chakraborty, Mercedes Hennessey, Aminah J. Tannir, Shrinidhi Byregowda, Seanu Meena Natarajan, Abel Trujillo-Ocampo, Jin Seon Im, Sangeeta Goswami   +9 more
openaire   +2 more sources

Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis

Cell Metabolism, 2023
Nissim HAY, Constantinos Chronis, Alexander Terry   +2 more
exaly  

Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease

Cell Metabolism, 2022
Zengqiang Yuan, Ju Gao, Lin He
exaly  

Histone Lactylation Boosts Reparative Gene Activation Post–Myocardial Infarction

Circulation Research, 2022
Maomao Zhang, Ping Sun, Naixin Wang
exaly  

Functioning and Molecular Mechanism of Histone Lactylation in AKI

Journal of the American Society of Nephrology, 2023
openaire   +1 more source

Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma

Immunity
Luca D'Angelo
exaly  

ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion

Cell Metabolism
Zhimin Lu
exaly  

Tumor-derived lactate promotes resistance to bevacizumab treatment by facilitating autophagy enhancer protein RUBCNL expression through histone H3 lysine 18 lactylation (H3K18la) in colorectal cancer

Autophagy
Weihao Li, Qingjian Ou, Ling-Heng Kong   +2 more
exaly