Results 191 to 200 of about 4,358 (213)
Some of the next articles are maybe not open access.
The crosstalking of lactate‐Histone lactylation and tumor
PROTEOMICS – Clinical Applications, 2023ABSTRACTLactate was once considered to be a by‐product of energy metabolism, but its unique biological value was only gradually explored with the advent of the Warburg effect. As an end product of glycolysis, lactate can act as a substrate for energy metabolism, a signal transduction molecule, a regulator of the tumor microenvironment and immune cells,
Yao Rong +7 more
openaire +2 more sources
Histone Lactylation: A New Role for Glucose Metabolism
Trends in Biochemical Sciences, 2020Lactate is an end product of glucose metabolism, which serves metabolic and nonmetabolic functions. A new study by Zhang et al. establishes a novel function for lactate whereby it is utilized in a new histone modification, histone lysine lactylation, to regulate gene expression in macrophages.
Maria V, Liberti, Jason W, Locasale
openaire +2 more sources
Biochemistry and regulation of histone lysine l-lactylation
Nature Reviews Molecular Cell BiologyXinlei Sheng, Hening Lin, Yingming Zhao
exaly +2 more sources
The TRIM33 Bromodomain Recognizes Histone Lysine Lactylation
ACS Chemical BiologyHistone lysine lactylation (Kla) regulates inflammatory gene expression in activated macrophages and mediates the polarization of inflammatory (M1) to reparative (M2) macrophages. However, the molecular mechanisms and key protein players involved in Kla-mediated transcriptional changes are unknown.
Raymundo Nuñez +6 more
openaire +2 more sources
Histone Lactylation Drives CD8 T Cell Metabolism and Function
2023SummaryThe activation and functional differentiation of CD8 T cells are linked to metabolic pathways that result in the production of lactate. Lactylation is a lactate-derived histone post-translational modification (hPTM); however, the relevance of histone lactylation in the context of CD8 T cell activation and function is not known. Here, we show the
Deblina, Raychaudhuri +7 more
openaire +2 more sources
The Oncogenic Regulation of Histone Lysine Lactylation
2021L-lactate is generated during glycolysis, a metabolic pathway that is widely associated with many physiological and disease related processes. We recently reported the discovery of lysine L-lactylation [K(L-la)] as a novel protein posttranslational modification occurring on histone proteins that can contribute to gene transcription.
openaire +1 more source
Histone Lysine Lactylation Regulates Gene Expression
Cancer Discovery, 2019Abstract A previously unknown histone modification, lysine lactylation, was found in mouse and human cells.
openaire +1 more source
Both L-lactyl and D-lactyl enantiomers modify histones in mouse testis
Abstract Dynamic histone post-translational modifications are crucial to precisely orchestrate gene expression programs. The recently discovered histone lysine lactylation has already been explored in various pathological contexts, but less in normal tissues.Julie Manessier +7 more
openaire +1 more source
Comprehensive review of histone lactylation: Structure, function, and therapeutic targets
Biochemical PharmacologyHistone lysine lactylation (Kla) has emerged as a distinct epigenetic modification that differs markedly from established acylation modifications through the unique addition of a lactyl group to a lysine residue. Such modifications not only alter nucleosome structure but also significantly impact chromatin dynamics and gene expression, thus playing a ...
Kaiwen Xu +3 more
openaire +2 more sources
Lumican promotes calcific aortic valve disease through H3 histone lactylation
European Heart JournalAbstract Background and Aims Valve interstitial cells (VICs) undergo a transition to intermediate state cells before ultimately transforming into the osteogenic cell population, which is a pivotal cellular process in calcific aortic valve disease (CAVD).
Yuming Huang +12 more
openaire +2 more sources