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Lactate, histone lactylation and cancer hallmarks
Expert Reviews in Molecular Medicine, 2023Abstract Histone lactylation, an indicator of lactate level and glycolysis, has intrinsic connections with cell metabolism that represents a novel epigenetic code affecting the fate of cells including carcinogenesis. Through delineating the relationship between histone lactylation and cancer hallmarks, we propose histone lactylation as a novel ...
Xinyu Lv, Yingying Lv, Xiaofeng Dai
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The crosstalking of lactate‐Histone lactylation and tumor
PROTEOMICS – Clinical Applications, 2023ABSTRACTLactate was once considered to be a by‐product of energy metabolism, but its unique biological value was only gradually explored with the advent of the Warburg effect. As an end product of glycolysis, lactate can act as a substrate for energy metabolism, a signal transduction molecule, a regulator of the tumor microenvironment and immune cells,
Yao Rong +7 more
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Histone Lactylation: A New Role for Glucose Metabolism
Trends in Biochemical Sciences, 2020Lactate is an end product of glucose metabolism, which serves metabolic and nonmetabolic functions. A new study by Zhang et al. establishes a novel function for lactate whereby it is utilized in a new histone modification, histone lysine lactylation, to regulate gene expression in macrophages.
Maria V, Liberti, Jason W, Locasale
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LDHA promotes osteoblast differentiation through histone lactylation
Biochemical and Biophysical Research Communications, 2022Osteoblast cells tend to metabolize glucose to lactate via aerobic glycolysis during osteogenic differentiation. However, the function of lactate in this process is still elusive. As a newly discovered protein posttranslational modification, lactate-derived histone lactylation has been found to play important roles in gene regulation and have profound ...
Feige, Nian +5 more
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Histone Lysine Lactylation Regulates Gene Expression
Cancer Discovery, 2019Abstract A previously unknown histone modification, lysine lactylation, was found in mouse and human cells.
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ImmunityImmunosuppressive macrophages restrict anti-cancer immunity in glioblastoma (GBM). Here, we studied the contribution of microglia (MGs) and monocyte-derived macrophages (MDMs) to immunosuppression and mechanisms underlying their regulatory function. MDMs
Ugolini, Alessio +16 more
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Comprehensive review of histone lactylation: Structure, function, and therapeutic targets
Biochemical PharmacologyHistone lysine lactylation (Kla) has emerged as a distinct epigenetic modification that differs markedly from established acylation modifications through the unique addition of a lactyl group to a lysine residue. Such modifications not only alter nucleosome structure but also significantly impact chromatin dynamics and gene expression, thus playing a ...
Kaiwen Xu +3 more
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Histone lactylation drives CD8+ T cell metabolism and function
Nature ImmunologyThe activation and functional differentiation of CD8+ T cells are linked to metabolic pathways that result in the production of lactate. Lactylation is a lactate-derived histone post-translational modification; however, the relevance of histone lactylation in the context of CD8+ T cell activation and function is not known.
Deblina Raychaudhuri +9 more
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Histone lactylation: A sensor of epigenetic reprogramming mediated by cellular metabolism
Cellular SignallingEpigenetic reprogramming plays a critical role in connecting genotype to phenotype, providing the flexibility that allows organisms to adapt to developmental needs, environmental shifts, and disease challenges through the flexible regulation of gene expression.
Lei, Wang +12 more
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