Results 221 to 230 of about 128,524 (232)

The regulatory role of protein lactylation in various diseases: Special focus on the regulatory role of non-histone lactylation

Gene
Lactylation, an emerging form of post-translational modification derived from lactate, plays a pivotal role in numerous cellular processes such as tumor proliferation, metabolism, inflammation, and embryonic development. However, the precise molecular mechanisms by which lactylation controls these biological functions in both physiological and ...
Peipei Wang, Kexin Lin, Degao Huang, Zihan Jiang, Linchuan Liao, Xia Wang   +5 more
openaire   +2 more sources

Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis

Cell Metabolism, 2023
Nissim Hay, Constantinos Chronis, Alexander R Terry   +2 more
exaly  

Histone Lactylation Boosts Reparative Gene Activation Post–Myocardial Infarction

Circulation Research, 2022
Maomao Zhang, Ping Sun, Naixin Wang
exaly  

Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease

Cell Metabolism, 2022
Zengqiang Yuan, Ju Gao, Lin He
exaly  

Functioning and Molecular Mechanism of Histone Lactylation in AKI

Journal of the American Society of Nephrology, 2023
openaire   +1 more source

Histone lactylation in macrophage biology and disease: from plasticity regulation to therapeutic implications

EBioMedicine
Xihong Ying, Dun Wang
exaly  

Tumor-derived lactate promotes resistance to bevacizumab treatment by facilitating autophagy enhancer protein RUBCNL expression through histone H3 lysine 18 lactylation (H3K18la) in colorectal cancer

Autophagy
Weihao Li, Qingjian Ou, Lingheng Kong
exaly  

ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion

Cell Metabolism
Zhimin Lu, Xiaoming Jiang
exaly  

Histone lactylation facilitates hepatocellular carcinoma progression by upregulating endothelial cell-specific molecule 1 expression

Molecular Carcinogenesis
Changhe Zhang, Chunzhong Qiao
exaly  

Developing diagnostic biomarkers for Alzheimer's disease based on histone lactylation-related gene

Heliyon
ZHANG Biao, Wenhui Zhu
exaly