Results 201 to 210 of about 4,358 (213)

Orphan Nuclear Receptor NR4A3 Promotes Vascular Calcification via Histone Lactylation

Circulation Research
BACKGROUND: Medial arterial calcification is a chronic systemic vascular disorder distinct from atherosclerosis and is commonly observed in patients with chronic kidney disease, diabetes, and aging individuals. We previously showed that NR4A3 (nuclear receptor subfamily 4 group A member 3), an orphan nuclear receptor, is a key ...
Wenqi Ma, Kangni Jia, Haomai Cheng, Hong Xu, Zhigang Li, Hang Zhang, Hongyang Xie, Hang Sun, Lei Yi, Zhiyong Chen, Shengzhong Duan, Motoaki Sano, Keiichi Fukuda, Lin Lu, Fei Gao, Ruiyan Zhang, Xiaoxiang Yan   +16 more
openaire   +2 more sources

Efficient synthesis of lactylated histone peptides enabled by a pre-prepared protected lactylated-lysine

Tetrahedron Letters, 2023
Qingyao Shu, Jian Fan, Bingji Wang, Jing Shi   +3 more
openaire   +1 more source

Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis

Cell Metabolism, 2023
Alexander R Terry, Nissim Hay
exaly  

Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease

Cell Metabolism, 2022
Zengqiang Yuan, Lin He, Xinhua Liu
exaly  

Demethylzeylasteral targets lactate by inhibiting histone lactylation to suppress the tumorigenicity of liver cancer stem cells

Pharmacological Research, 2022
Li Yang, Chunli Wang, Kang Xu
exaly  

Endothelial Cell‐Derived Lactate Triggers Bone Mesenchymal Stem Cell Histone Lactylation to Attenuate Osteoporosis

Advanced Science, 2023
Heng Jiang, Zheng Zhang, Yichen Meng
exaly  

ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion

Cell Metabolism
Ying Meng, Qingang Wu, Zhimin Lu
exaly  

Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma

Immunity
Filippo Veglia, Conejo-Garcia J Or Conejo-Garcia Jr Or Conejo Jr Or Garcia Jr Forssmann, Antonio Santoro   +2 more
exaly  

Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory

Cell
Titus Schlüter, Anaísa V Ferreira, Valerie A C M Koeken   +2 more
exaly  

Tumor-derived lactate promotes resistance to bevacizumab treatment by facilitating autophagy enhancer protein RUBCNL expression through histone H3 lysine 18 lactylation (H3K18la) in colorectal cancer

Autophagy
Weihao Li, Jian-Hong Peng
exaly