Correction to: Hypoxia-induced histone lactylation promotes pulmonary arterial smooth muscle cells proliferation in pulmonary hypertension. [PDF]
Mol Cell BiochemChen A +5 more
europepmc +1 more source
Correction: Non-histone lactylation: unveiling its functional significance. [PDF]
Front Cell Dev BiolShi P, Ma Y, Zhang S.
europepmc +1 more source
P300 enhances glycolysis and dox resistance in DLBCL by upregulating HK2 expression through histone lactylation. [PDF]
BMC CancerSong X, Fu H, Zhong X, Yu N, Zhang W.
europepmc +1 more source
Correction to "Homeobox B13 activates the hypoxia-inducible factor 1 pathway through histone lactylation thereby reprogramming lipid metabolism and promoting sorafenib resistance in hepatocellular carcinoma". [PDF]
J Cell Commun Signaleuropepmc +1 more source
RETRACTION: Histone Lactylation-Driven Upregulation of VRK1 Expression Promotes Stemness and Proliferation of Glioma Stem Cells. [PDF]
Adv Sci (Weinh)europepmc +1 more source
Histone Lactylation Dynamics in Plasmodium falciparum
, 2023 Epigenetic modifications of the histone are a rapidly unfolding field of research with new posttranslational modifications being uncovered at a rapid pace. Histone lactylation is a newly identified modification associated with metabolism and it has been shown to exist in various organisms including humans and parasites.
Smith, Jared
core +4 more sources
The Role of Hexokinase 2 in the Regulation of Histone Lactylation
, 2023 Lactate, previously considered as a metabolic waste product, has been implicated in the induction of gene expression in activated hepatic stellate cells (HSCs). However, the mechanism by which lactate exerts its effect remains unknown. We demonstrate that the catalytic activity of hexokinase 2 (HK2) is sufficient to alter gene expression by histone ...
Hyunsoo Rho (16526988)
openaire +2 more sources
The Oncogenic Regulation of Histone Lysine Lactylation [PDF]
, 2021 L-lactate is generated during glycolysis, a metabolic pathway that is widely associated with many physiological and disease related processes. We recently reported the discovery of lysine L-lactylation [K(L-la)] as a novel protein posttranslational modification occurring on histone proteins that can contribute to gene transcription.
Perez-Neut, Mathew
openaire +2 more sources
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Augmentation of scleral glycolysis promotes myopia through histone lactylation
Cell MetabolismMyopia is characterized of maladaptive increases in scleral fibroblast-to-myofibroblast transdifferentiation (FMT). Scleral hypoxia is a significant factor contributing to myopia, but how hypoxia induces myopia is poorly understood. Here, we showed that myopia in mice and guinea pigs was associated with hypoxia-induced increases in key glycolytic ...
Zhengbo Xue
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