Results 131 to 140 of about 128,524 (232)

Glis1 regulates metabolic programming by promoting H3K18 lactylation to alleviate neuronal senescence following spinal cord injury

Genes and Diseases
Neuronal senescence is a significant factor impeding spinal cord injury (SCI) repair. Research indicates that Glis1, a Kruppel-like zinc finger transcription factor, is pivotal in reprogramming senescent cells and enhancing genomic stability via ...
Dachuan Li, Xiao Lu, Zhaoyang Gong, Jianwei Wu, Yuxuan Zhang, Jiongdong Wu, Chenpei Xu, Xingyu Guo, Guangyu Xu, Haocheng Xu, Shuo Yang, Xinlei Xia, Feizhou Lu, Jianyuan Jiang, Shihao Lu, Junzhe Sheng, Xiaosheng Ma, Wei Zhu, Fei Zou, Chi Sun, Xiaochuan Gu, Yunzhi Guan   +21 more
doaj   +1 more source

Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation

Summary: Macrophage activation is a hallmark of atherosclerosis, accompanied by a switch in core metabolism from oxidative phosphorylation to glycolysis.
Longbin Zheng, Minghong Chen, Xian He, Fuhao Liu, Yongfeng Shao, Jiao Min, Hong Jiang, Xuesong Li, Yongkang Tan, Hongshan Chen, Xiang Chen, Mengdie Dong, Quanwen Yin, Yunjia Zhang   +13 more
core   +1 more source

Cancer‐associated fibroblast heterogeneity across solid and haematological malignancies: Lessons from colorectal cancer and multiple myeloma

The Journal of Physiology, EarlyView.
Abstract figure legend CAF origins and plasticity give rise to distinct phenotypes with immunosuppressive functions in colorectal cancer and multiple myeloma. These distinct CAF phenotypes contribute to immunosuppressive tumour microenvironments through ECM remodelling, cytokine signalling and immune regulation.
Hui Mo, Haoyan Han, Michael O'Dwyer, Eileen Reidy, Aideen E. Ryan   +4 more
wiley   +1 more source

Elevated Histone Lactylation Mediates Ferroptosis Resistance in Endometriosis Through the METTL3‐Regulated HIF1A/HMOX1 Signaling Pathway

Endometriosis (EMs) is a chronic gynecologic condition characterized by the growth of endometrial stromal and glandular tissue outside the uterine cavity of unknown etiology.
Yingying Cao, Yanling Gou, Ruru Bai, Huiyan Zhang, Zongfeng Zhang, Honglin Wang, Zongwen Liang, Jinming Liu, Zhi Li   +8 more
core   +1 more source

BDH1 Attenuates Macrophage Foam Cell Formation and Inflammation in Atherosclerosis Via Modulating Histone H3K9 Acylation Balance and Activating PPAR Signaling

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
In atherosclerotic lesions, BDH1 expression is downregulated in plaque macrophages. In ox‐LDL‐induced RAW264.7 macrophages, BDH1 overexpression maintains H3K9 acylation homeostasis by upregulating H3K9ac and downregulating H3K9bhb, thereby increasing cell viability, reducing lipid accumulation, decreasing TNF‐α, and increasing IL‐10.
Yu Wang, Yi Wang, Qinghong Liu, Mao Tian, Bin Wang, Qiang Lin, Shuiying Huang   +6 more
wiley   +1 more source

SIRT7 Mediated‐PTEN Desuccinylation Drives Gastric Tumorigenesis by Activating PI3K/AKT Pathway

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
SIRT7 is upregulated in gastric cancer (GC). SIRT7‐mediated desuccinylation of PTEN at K322/K330 promotes its degradation, thereby activating the PI3K/AKT signaling pathway and ultimately driving GC progression. ABSTRACT SIRT7 is linked to cancer, yet its function in gastric cancer (GC) remains unclear.
Bingling Liao, Sheng Hu, Qilin Zhang, Qihua Xu, Tianning Tian   +4 more
wiley   +1 more source

The Efferocytosis‐Driven Macrophage Polarization: A Concerto in the Tumor Immunosuppressive Microenvironment

MedComm, Volume 7, Issue 11, November 2026.
Efferocytosis is a key process for macrophages to clear apoptotic cells, which undergoes the “ Find Me” chemotaxis signal stage, the “eat me” phagocytosis recognition stage and the “digest me” digestion stage in turn. During the aforementioned three stages, various signaling molecules released by apoptotic cells can promote the phenotypic polarization ...
Qiuping Chen, Chunzhi Wu, Changquan Huang, Hang Zhou   +3 more
wiley   +1 more source

Histone Modifications at the Intersection of Aging, Neuroinflammation and Metabolism in Alzheimer's Disease

Aging Cell, Volume 25, Issue 11, November 2026.
This review examines how histone modifications integrate aging, metabolic dysfunction and neuroinflammation to shape persistent, cell‐type‐specific chromatin states in Alzheimer's disease. By distinguishing causal regulation from association through perturbation, persistence and reversibility, it highlights metabolic–epigenetic feedback loops and ...
Junyi Liang, Huawen Cao, Xiumin Ren, Nan Sha, Xueqing Han, Ling Jiang, Bin Liu, Weiming Zhao   +7 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, Volume 600, Issue 19, Page 2850-2873, October 2026.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Lipopolysaccharide-induced histone lactylation mediates m6A RNA modification causing mitochondrial dysfunction and pulmonary fibroblasts activation to exacerbate sepsis-associated pulmonary fibrosis

Respiratory Research
Background Histone lactylation and N6-methyladenosine (m6A) alteration are epigenetic modifications that have a crucial function in controlling gene expression throughout fibroblast activation and organ fibrosis. However, their roles in sepsis-associated
Ri Tang, Shaojie Qin, Qiaoyi Xu, Wenyu Lin, Shuyi Zhang, Yawen Peng, Jinhua Feng, Shunpeng Xing, Yuan Gao, Shuya Mei, Zhengyu He   +10 more
doaj   +1 more source