Results 131 to 140 of about 4,358 (213)

Histone Changes as a Response to Lactic Acid Selection in Cells of Austrofundulus limnaeus [PDF]

The killifish Austrofundulus limnaeus is an extremophile native to small temporary ponds of Venezuela. Normal embryonic development of A. limnaeus is segmented into up to three stages of metabolic depression (diapause), and both developing and diapausing
Hughes, Chelsea, Podrabsky, Jason, Tran, Lori   +2 more
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Histone lactylation promotes malignant progression by facilitating USP39 expression to target PI3K/AKT/HIF-1α signal pathway in endometrial carcinoma

Cell Death Discovery
Histone lactylation has been reported to involve in tumorigenesis and development. However, its biological regulatory mechanism in endometrial carcinoma (EC) is yet to be reported in detail.
Sitian Wei, Jun Zhang, Rong Zhao, Rui Shi, Lanfen An, Zhicheng Yu, Qi Zhang, Jiarui Zhang, Yuwei Yao, Haojia Li, Hongbo Wang   +10 more
doaj   +1 more source

Lactate and lactylation in macrophage metabolic reprogramming: current progress and outstanding issues [PDF]

It is commonly known that different macrophage phenotypes play specific roles in different pathophysiological processes. In recent years, many studies have linked the phenotypes of macrophages to their characteristics in different metabolic pathways ...
Bangjun Xu, Ning Li, Qing Geng, Yi Liu
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Histone lactylation [PDF]

Nature Immunology, 2019
openaire   +2 more sources

Lipopolysaccharide-induced histone lactylation mediates m6A RNA modification causing mitochondrial dysfunction and pulmonary fibroblasts activation to exacerbate sepsis-associated pulmonary fibrosis

Respiratory Research
Background Histone lactylation and N6-methyladenosine (m6A) alteration are epigenetic modifications that have a crucial function in controlling gene expression throughout fibroblast activation and organ fibrosis. However, their roles in sepsis-associated
Ri Tang, Shaojie Qin, Qiaoyi Xu, Wenyu Lin, Shuyi Zhang, Yawen Peng, Jinhua Feng, Shunpeng Xing, Yuan Gao, Shuya Mei, Zhengyu He   +10 more
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The role of lactylation in tumor growth and cancer progression

Frontiers in Oncology
BackgroundLactate’s perception of lactate has changed over the last 30 years from a straightforward metabolic byproduct to a complex chemical with important biological activities, such as signal transduction, gluconeogenesis, and mitochondrial ...
Khulood Al-Malsi, Khulood Al-Malsi, Khulood Al-Malsi, Sinan Xie, Sinan Xie, Sinan Xie, Yunshi Cai, Yunshi Cai, Yunshi Cai, Nader Mohammed, Kunlin Xie, Kunlin Xie, Kunlin Xie, Tian Lan, Tian Lan, Tian Lan, Hong Wu, Hong Wu, Hong Wu   +18 more
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Lactylation as a cross-regulatory node in tumor metabolism and epigenetics: insights and therapeutic implications [PDF]

Lactylation serves as a pivotal cross-regulatory mechanism linking tumor metabolic reprogramming and epigenetic regulation. This review comprehensively summarizes the mechanisms of lactylation writers, erasers, and readers, highlighting their tumor ...
Jinhua Wu, Junna Jiao, Junna Jiao, Lulu Liu, Ruihan Wang, Ruohao Yang, Xiaoyu Shi, Zhuangwei Lv   +7 more
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Lactylation of histone by BRD4 regulates astrocyte polarization after experimental subarachnoid hemorrhage

Journal of Neuroinflammation
Under subarachnoid hemorrhage (SAH) conditions, astrocytes undergo a marked intensification of glycolytic activity, resulting in the generation of substantial amounts of lactate to maintain the energy demand for neurons and other brain cells. Lactate has
Fan Zhang, Jian Zhou, Peng Lu, Xianhui Zhang, Lei Yang, Jinpeng Wu, Lihan Zhang, Lifang Zhang, Jinwei Pang, Huangfan Xie, Bingqing Xie, Yong Jiang, Jianhua Peng   +12 more
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Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation

Cell Reports
Summary: Macrophage activation is a hallmark of atherosclerosis, accompanied by a switch in core metabolism from oxidative phosphorylation to glycolysis.
Yunjia Zhang, Hong Jiang, Mengdie Dong, Jiao Min, Xian He, Yongkang Tan, Fuhao Liu, Minghong Chen, Xiang Chen, Quanwen Yin, Longbin Zheng, Yongfeng Shao, Xuesong Li, Hongshan Chen   +13 more
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Lactylation in CNS disorders: mechanisms, cellular function, and disease relevance [PDF]

Lactate, as a metabolic product or energy substrate, participates in various neurological processes within the physiological and pathological frameworks of the central nervous system (CNS).
Jiaxin Tian, Jingyu Dong, Jinpeng Zhou, Ruidan Zhang, Sijia Hao, Tongyu Zhang, Yang Tian, Yiyan Chen   +7 more
core   +1 more source