Results 131 to 140 of about 4,116 (175)

Histone lactylation: A key epigenetic modulator in the pathogenesis of metabolic dysfunction-associated steatohepatitis and alcoholic steatohepatitis. [PDF]

World J Hepatol
Singh MM, Shah A, Rajak S, Chaturvedi CP, Sinha RA.   +4 more
europepmc   +1 more source

Monocyte-derived exosomal periostin driven by histone lactylation contributes to retinal neovascularization. [PDF]

Proc Natl Acad Sci U S A
Shen W, Nie Z, Wang M, Zhang H, Liu Y, Zhu H, Zhou W, Zhang L, Zhao M, Zeng H, Peng M, Zhou Y, Zhao J, Wang S, Gao G, Jiang Y, Zou W, Shen X, Wang L, Song H.   +19 more
europepmc   +1 more source

Investigating the Mechanistic Link Between Lactate-Induced Histone Lactylation and Cellular Senescence in Osteoarthritis Chondrocytes: Implications for Therapy. [PDF]

Int J Biol Sci
Zuo R, Wu C, Lin Z, Kong L, Wang F, Zhang X, Wei J, Lin Y, Yang E, Kang Q, Zhao S, Guan J, Zhao J.   +12 more
europepmc   +1 more source

Histone lactylation leads to perioperative neurocognitive disorders by promoting the expression of Ralbp1 and inducing excessive mitochondrial fission in hippocampal neurons. [PDF]

Cell Mol Life Sci
Meng F, Cao S, Wu W, Zhang M, Jing Q, Xie Z, Sun X, Song J, Fei M, Chen Q, Gao X, Li C.   +11 more
europepmc   +1 more source

Homeobox B13 activates the hypoxia-inducible factor 1 pathway through histone lactylation thereby reprogramming lipid metabolism and promoting sorafenib resistance in hepatocellular carcinoma. [PDF]

J Cell Commun Signal
Xie Q, Teng F, Ding T, Zhang H, Huang J, Zhang S.   +5 more
europepmc   +1 more source

Cyclin B2 facilitates glycolysis and tumor progression in pancreatic ductal adenocarcinoma by promoting histone lactylation. [PDF]

BMC Cancer
Ma B, Li X, Ma Z, Yin Z, Gao L, Wang Y, Shi J, Liu X, Chen H.   +8 more
europepmc   +1 more source

DHX9 transcriptional upregulation and lactylation at K1024 fuels a glycolysis–histone lactylation loop in osteosarcoma

Journal of Translational Medicine
Hao Wang, Zhongxuan Wu, Rui Yang, Shenglin Xu, Shunjie Yao, Ziheng Wu, Longze Xiao, Yukang Que, Peng He, Qiming Ma, Tangbing Xu, Wei Wei, Yong Hu   +12 more
openaire   +1 more source

Delactylase effects of SIRT3 on a positive feedback loop involving the RUNX1-glycolysis-histone lactylation in diabetic kidney disease. [PDF]

Int J Biol Sci
Shen S, Ying C, Fu X, Zeng X, Guo X, Wu H, Zhang L, Xu L.   +7 more
europepmc   +1 more source

Narciclasine Alleviates Endothelial Inflammation and Atherosclerosis Initiation by Inhibiting Histone Lactylation-Mediated NF-κB Activation. [PDF]

Inflammation
Wang Z, Zhang Z, Xin R, Ma M, Sun Z, Li Z, Zhang C, Liu L, Wu Z, Zhang Y, Chen Y.   +10 more
europepmc   +1 more source

OSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension. [PDF]

Cell Prolif
Yang L, Ni Q, He Y, Liu S, Gan L, Dai A, Hu Y, Liu Q, Yang X, Li J, Tao Y, Li Y, Xu M.   +12 more
europepmc   +1 more source